NatureFeedbackdegronLOCKR

Code and data used for:

Ng, A. H., Nguyen, T. H., Gómez-Schiavon, M., Dods, G., Langan, R. A., Boyken, S. E., … El-Samad, H. (2019). Modular and tunable biological feedback control using a de novo protein switch. Nature, 572(7768), 265–269. https://doi.org/10.1038/s41586-019-1425-7

iPython notebook files are provided for analyzing the data in the main text and extended data. Raw flow cytometry data can be provided upon reasonable request.

MATLAB files are provided that were used for performing simulations of model.

Name		Name	Last commit message	Last commit date
Latest commit History 102 Commits
BIOREACTOR		BIOREACTOR
MODEL		MODEL
AHN_MatingPathwayDegradation.ipynb		AHN_MatingPathwayDegradation.ipynb
AHN_MatingPathwayFus3FB.ipynb		AHN_MatingPathwayFus3FB.ipynb
AHN_MatingPathwaySte12FB.ipynb		AHN_MatingPathwaySte12FB.ipynb
AHN_MatingPathwaySte12FBtuning.ipynb		AHN_MatingPathwaySte12FBtuning.ipynb
AHN_SyntheticCircuitConstitutivePromoters.ipynb		AHN_SyntheticCircuitConstitutivePromoters.ipynb
AHN_SyntheticCircuitDoseResponse.ipynb		AHN_SyntheticCircuitDoseResponse.ipynb
AHN_SyntheticCircuitTuning.ipynb		AHN_SyntheticCircuitTuning.ipynb
README.md		README.md
THN20180917_MAT_STE12doseresponse_triplicates.ipynb		THN20180917_MAT_STE12doseresponse_triplicates.ipynb
THN20180920_MAT_STE12tuning_triplicates.ipynb		THN20180920_MAT_STE12tuning_triplicates.ipynb
THN20181011_GEMZPM_syntuning_triplicates.ipynb		THN20181011_GEMZPM_syntuning_triplicates.ipynb
THN20181012_GEMZPM_pgdisturbance_triplicates.ipynb		THN20181012_GEMZPM_pgdisturbance_triplicates.ipynb
THN20181212_GEMZPM_PSDdisturbance_triplicates.ipynb		THN20181212_GEMZPM_PSDdisturbance_triplicates.ipynb
THN20190222_MAT_Fus3doseresponse_triplicates.ipynb		THN20190222_MAT_Fus3doseresponse_triplicates.ipynb

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