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Pertussis
rnunez-IDM edited this page Jul 16, 2019
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25 revisions
- Greg Hart
- Katelin Jackson
- Rafael Nunez
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Exercise 1: Review main immune interactions for chosen pathogens
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- Question 1: What are the main immune selective pressures on the pathogen?
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- One of the main driving forces for the evolution of B. pertussis is the immune pressure of vaccination (citation https://www.nature.com/articles/srep12888).
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- There is a chance that a fully vaccinated person, of any age, can catch this disease but the infection is mild (citation https://www.cdc.gov/pertussis/about/causes-transmission.html)
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- Possibly zoonotic; non-human primates are highly susceptible to B. pertussis. Zoos vaccinate their primates. unknown if it's in wildlife or just circulating within zoos (citation https://en.wikipedia.org/wiki/Bordetella_pertussis#As_a_zoonotic_disease).
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- Two toxins are responsible for inhibiting the immune system.
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- paper answers bigger q1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963054/
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Exercise 2: investigate pathogen-specific serological data
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- Question 2: how many "strains" exist for your pathogen? Are there canonical serotypes? Or is it fuzzier?
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- There doesn't seem to be any other bacteria strains, however, from the vaccine there can be pertactin-deficient strains which can lead to vaccinated individuals to get infected (citation https://www.cdc.gov/pertussis/pertactin-neg-strain.html).
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- bacteria strains, etc.: https://bedford.io/projects/sismid/lineup/pertussis/bart-pertussis-genetics.pdf
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Population dynamics/timeseries: