Update B cell lecture

bcells/slides.html

@@ -124,11 +124,6 @@ <h3>Affinity maturation</h3>
 					<img class="stretch" src="images/gc.png">
 				</section>
 
-				<section>
-					<h3>Affinity maturation</h3>
-					<img class="stretch" src="images/nk_epitopes.png">
-				</section>
-
 				<section>
 					<h3>Dynamics in one GC</h3>
 					<img class="stretch" src="images/gc_dynamics.png">
@@ -138,6 +133,16 @@ <h3>Dynamics in one GC</h3>
 							</a>
 						</div>
 				</section>
+
+                <section>
+                    <h3>GC B cells evolve</h3>
+                    <img class="stretch" src="images/gc_micro.png">
+                        <div class="citation">
+                            <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119370/pdf/je1763679.pdf">
+                                Jacob and Kelsoe 1992
+                            </a>
+                        </div>
+                </section>
 
 				<section>
 					<h3>AID induces somatic hypermutation</h3>
@@ -150,24 +155,15 @@ <h3>AID induces somatic hypermutation</h3>
 				</section>
 
 				<section>
-					<h3>Mutation rate varies over BCR</h3>
+					<h3>Mutation rate varies over the variable region</h3>
 					<img class="stretch" src="images/mutations_bcr.jpg">
 						<div class="citation">
 							<a href="http://www.pnas.org/content/112/7/E728.full">
 								Wei et al. 2015
 							</a>
 						</div>
 				</section>
-
-				<section>
-					<h3>GC B cells evolve</h3>
-					<img class="stretch" src="images/gc_micro.png">
-						<div class="citation">
-							<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119370/pdf/je1763679.pdf">
-								Jacob and Kelsoe 1992
-							</a>
-						</div>
-				</section>
+
 
 				<section>
 					<h3>GCs produce plasma and memory cells</h3>
@@ -180,7 +176,7 @@ <h3>GCs produce plasma and memory cells</h3>
 				</section>
 
 				<section>
-					<h3>Memory cells can affinity mature</h3>
+					<h3>Memory cells can evolve further</h3>
 					<img src="images/andrews_memory.jpg" style="width: 70%; height: 70%;">
 						<div class="citation">
 							<a href="http://stm.sciencemag.org/content/7/316/316ra192">
@@ -354,6 +350,19 @@ <h3>"Antigenic seniority"</h3>
 				<section data-background="#99CCFF">
 					<h3>What's so special about early infections?</h3>
 				</section>
+
+
+                <section>
+                    <h3>A general model of sin</h3>
+                    <img src="images/oas_schematic.png">
+                        <div class="citation">
+                            <a href="http://dx.doi.org/10.1016/j.coviro.2016.12.004">
+                                Cobey and Hensley 2017
+                            </a>
+                        </div>
+                        </section>
+
+
 
 				<section>
 					<h3>Response to 2009 H1N1 vaccine</h3>
@@ -402,6 +411,69 @@ <h3>Potential factors influencing specific antibody responses</h3>
 					<p>Immunogenicity
 					<p>Autoreactivity
 				</section>
+
+                <section>
+                    <h3>In U.S., flu vaccine coverage is high</h3>
+                    <img src="images/vaccine_coverage.png" style="width: 60%; height: 60%;">
+                    <div class="citation">
+                        <a href="https://www.cdc.gov/flu/fluvaxview/coverage-1516estimates.htm">
+                            FluVaxView
+                        </a>
+                    </div>
+                </section>
+
+                <section>
+                    <h3>In RCT, vaccine provides high indirect protection</h3>
+                    <img src="images/hutterite.png" style="width: 90%; height: 90%;">
+                        <div class="citation">
+                            <a href="http://jamanetwork.com/journals/jama/fullarticle/185509">
+                                Loeb et al. 2010
+                            </a>
+                        </div>
+                </section>
+
+                <section>
+                    <h3>Influenza vaccine effectiveness is low</h3>
+                    <p>H3N2: 33% (95% CI: 26-39)
+                    <p>B: 54% (46-61)
+                    <p>pH1N1: 61% (57-65)
+                    <p>H1N1: 67% (29-85)
+                        <div class="citation">
+                            <a href="http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(16)00129-8/abstract">
+                                Belongia et al. 2016
+                            </a>
+                    </div>
+                </section>
+
+                <section>
+                    <h3>What's going on?</h3>
+                    <p>Poor strain selection (antigenic mismatch)
+                    <p>Egg adaptations (antigenic mismatch)
+                    <p>Something else...?
+                </section>
+
+                <section>
+                    <h3>Low VE from repeat vaccinations</h3>
+                    <img src="images/mclean.jpg" style="width: 90%; height: 90%;">
+                    <div class="citation">
+                        <a href="https://www.ncbi.nlm.nih.gov/pubmed/25270645">
+                            McLean et al. 2014
+                        </a>
+                    </div>
+                </section>
+
+                <section>
+                    <h3>Eggs blamed in 2012-2013</h3>
+                    <p>IVR-165 distinct from Vic/361 in ferrets, but not people
+                    <img src="images/ivr165.png" style="width: 50%; height: 50%;">
+                        <div class="citation">
+                            <a href="http://www.biorxiv.org/content/early/2017/07/05/158550">
+                                Cobey et al. 2017
+                            </a>
+                        </div>
+                        </section>
+
+
 
 			</div>