580.639 Models of the Neuron Term Project
If you plot the steady-state voltage profiles of all compartments from our hippocampal pyramidal neuron, it looks a lot like a hippocampal cross section - meta!
In this project, we modified an existing model of calcium dependent plasticity dynamics to include dependence on Norepinephrine. The model followed from experimental evidence that NE acts on the same serines as those in Shouval's Calcium model. After modeling these synaptic changes, we studied how they manifested in the voltage at the soma when a current was applied to the dendrites. We found that our model closely followed the temporal and electrical profile of experimental slice data. Slides for our final presentation can be viewed here: https://docs.google.com/presentation/d/1qA0ptpP1VwAh86cc4pxWtKQ_ngGWgLNuy_s_IOgriio/edit?usp=sharing
- The main code deals with importing the morphological data contained in the mat files.
- The multiple mat files contain the neuron morphology data.
- Shouval "A unified model of NMDA receptor-dependent bidirectional synaptic plasticity" http://www.pnas.org/content/99/16/10831
- Huganir, Malinow "Emotion Enhances Learning via Norepinephrine Regulation of AMPA-Receptor Trafficking" https://www.sciencedirect.com/science/article/pii/S0092867407012056