Tumors that respond poorly to bevacizumab show upregulation of angiogenesis genes.

Roshan Lodha 09 February, 2024

Bulk RNA-sequencing analysis

Loading required packages and tools

Preprocessing

Postprocessing

Bulk-RNA Analysis

DGE Plot

GSEA Plot

## # A tibble: 23 × 2
##    gs_cat gs_subcat        
##    <chr>  <chr>            
##  1 C1     ""               
##  2 C2     "CGP"            
##  3 C2     "CP"             
##  4 C2     "CP:BIOCARTA"    
##  5 C2     "CP:KEGG"        
##  6 C2     "CP:PID"         
##  7 C2     "CP:REACTOME"    
##  8 C2     "CP:WIKIPATHWAYS"
##  9 C3     "MIR:MIRDB"      
## 10 C3     "MIR:MIR_Legacy" 
## # ℹ 13 more rows

Angiogenesis Gene Expression Plot

Collagen Gene Expression Plot

Figure 1

Protein Level Analysis

EGR1 Expression

Figure 2

Non-EGR1 Expression

a7-nAChR Intensity

SOX10 Expression

Correlation between a7-nAChR and EGR1

Figure 3

Survival Analysis

GBM Analysis

TCGA RNA Analysis

EGR1-Stratified Angiogenesis Expression

EGR1-Stratified Collagen Expression

EGR1-Stratified Average Expression Boxplot

EGR1-Stratified Survival Plot

EGR1-Stratified Recurrent Tumor Survival Plot

Figure 5

Other Cancers

Pan-Cancer Analysis

Lung Cancer Analysis

Other Genes

CHRNA7 Survival Plot

SOX10 Survival Plot

EGR3 Survival Plot

RAMP3 Survival Plot

Other Genes Plot