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lassie

Longitudinal Antigenic Sites and Sequences from Intrahost Evolution

or

Longitudinal Antigenic Swarm Selection from Intrahost Evolution

An R package of tools to select sites and sequences that represent variation in a longitudinally sampled protein alignment.

Installation and Getting Started:

  1. Start R, by whatever method you choose.
  2. Type "install.packages('devtools')".
  3. If prompted to compile a required package from source, you can safely decline without ill effects.
  4. Type "devtools::install_github('phraber/lassie').
  5. Type "vignette('lassie')".
  6. Run "?lassie::lassie" to begin reading the documentation.

If the you cannot view the vignette, it is available in PDF format here - https://github.com/phraber/lassie/blob/master/tutorial.pdf

Check out the shiny interface, which runs this code interactively:

https://github.com/phraber/meta-lass/

Legalese

©2017-2019. Triad National Security, LLC. All rights reserved.

This program was produced under U.S. Government contract 89233218CNA000001 for Los Alamos National Laboratory (LANL), which is operated by Triad National Security, LLC for the U.S. Department of Energy/National Nuclear Security Administration.

All rights in the program are reserved by Triad National Security, LLC, and the U.S. Department of Energy/National Nuclear Security Administration. The Government is granted for itself and others acting on its behalf a nonexclusive, paid-up, irrevocable worldwide license in this material to reproduce, prepare derivative works, distribute copies to the public, perform publicly and display publicly, and to permit others to do so.

Recall that this copyright notice must be accompanied by the appropriate open source license terms and conditions.

This is open source software; you can redistribute it and/or modify it under the terms of the GPL-2.0 License. If software is modified to produce derivative works, such modified software should be clearly marked, so as not to confuse it with the version available from LANL. Full text of the GPL-2.0 License can be found in the LICENSE file in the main development branch of the repository.

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Select sites and sequences from a serially sampled alignment

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