You signed in with another tab or window. Reload to refresh your session.You signed out in another tab or window. Reload to refresh your session.You switched accounts on another tab or window. Reload to refresh your session.Dismiss alert
@Al-MurphyMultiEWCE::prioritise_targets could be further extended by identifying key regulators of gene sets. This way, we can target all candidate genes by targeting a single regulator gene:
On a related note, try to find pathway-specificity of each regulator. We want to avoid disrupting other processes/pathways within a celltype by targeting a given regulator.
I don't know if identifying regulator genes is the ideal approach since there would always be off-target effects (by definition these are involved in the regulation of more than one gene). I think the ideal would be finding a gene in the same pathway as a gene of interest that we can't target (for example because of gene length) but that also meets all the other criteria you set out (i.e. specific to the cell type etc).
@Al-Murphy
MultiEWCE::prioritise_targets
could be further extended by identifying key regulators of gene sets. This way, we can target all candidate genes by targeting a single regulator gene:Useful tools:
gprofiler2
enrichR
clusterProfiler
@Al-Murphy let me know if you have any other suggestions!
The text was updated successfully, but these errors were encountered: