Sanjay Kharche, Ph.D. August 12, 2017. Sanjay.Kharche@lhsc.on.ca
This repository contains the anatomical model data of the human sinoatrial node (SAN) region's anatomy. The original computational anatomy was obtained from a previous histology study:
Chandler, N., Aslanidi, O., Buckley, D., Inada, S., Birchall, S., Atkinson, A., Kirk, D., Monfredi, O., Molenaar, P., Anderson, R., Sharma, V., Sigg, D., Zhang, H., Boyett, M. and Dobrzynski, H. (2011), Computer Three-Dimensional Anatomical Reconstruction of the Human Sinus Node and a Novel Paranodal Area. Anat Rec, 294: 970–979. doi:10.1002/ar.21379.
The anatomy was modified in the study by Kharche et al.: Kharche SR, Vigmond E, Efimov IR, Dobrzynski H (2017) Computational assessment of the functional role of sinoatrial node exit pathways in the human heart. PLoS ONE 12(9): e0183727. https://doi.org/10.1371/journal.pone.0183727
The original and modified SAN, as well as modified full 3D model anatomy used in Kharche et al. is provided in this publicly available git-hub repository. Please cite our papers as given above when using the anatomy in your scientific/academic studies.
The 3D model slices are in the X-Y plane whereas the Z axis goes through consecutive planes, please see Figure 1 of Kharche et al. The inplane resolution of the model is 0.25 mm x 0.25 mm. The interplane resolution of the model is 0.5 mm.
The model files are provided in legacy VTK format (ASCII data) to facilitate rapid visualisation as well as construction of 3D computational models. The shape of the original SAN is also provided.
- originalSAN.vtk
This is the original SAN anatomy as segmented from histology by Chandler et al.
- humanSAN_geometry2.vtk
This is the modified ellipsoidal SAN anatomy used in Kharche et al.
- humanSAN_geometry3.vtk
This is the paranodal area structure in the anatomy.
- humanSAN_geometry4.vtk, humanSAN_geometry5.vtk
These 2 files provide distribution of atrial tissue in the anatomy.
- humanSAN_geometry6.vtk
This file has the SAN border zone with exit pathways.