axon simulations

• tapering axon simulation code based on Johnson, Holmes, Brown, and Jung 2015

setup

run the code

• clone the repo
• compile the mod files (differs based on OS - see NEURON documentation)
• run main.hoc

todo

reference

goals

1. maximize velocity
2. minimize energy
3. minimize noise variability

constraints

• amount of protein membrane can sustain

hypotheses

• node only gets to minimum needed
  • see brill et al ~1997
• Resting potential might be getting messed up
• Look at changing gbar
• Look at changing potassium conductances

notes

• currently fires with noise
  • fires at very low voltage
• Johnson, Holmes, Brown, and Jung 2015
  • Goal: maximize conduction velocity but minimize metabolic costs
  • Myelination does this by decreasing capacitance
  • Increasing axon diameter does this by increasing ion flow
  • They assume fixed number of sodium channels and change morphology
  • 3 different taperings along the PARA
• other papers
  • base on Mcintyre, Richardson, and Grill 2001
  • empirical fits to blight, 1985 rat recording and david, 1995 rat recording

done

• fixed surface area and looked at different diameters