Wright-Fisher Lab:
- A pre-lab assignment meant to introduce students to writing simple R scripts
- A .Rmd applying the methods covered in the pre-lab to implement the classic Wright-Fisher diffusion model of population genetics. Students will examine the fluctuation of simulated allele frequencies over time in response to changes in mutation rate and selection coefficient.
Kennewick Man Lab:
- A Jupyter notebook assignment illustrating the use of Principal Component Analysis (PCA) to visualize genetic relatedness. Students will make PC plots comparing genetic data from individuals of the 1000 Genomes Project and infer the geographic identity of a sample collected from an unknown location.
- A document exploring the story of the Kennewick Man and walking students through the history and scientific approaches to identifying his ancestry.
References:
- 1000 Genomes Project Consortium, Adam Auton, Lisa D. Brooks, Richard M. Durbin, Erik P. Garrison, Hyun Min Kang, Jan O. Korbel, et al. 2015. “A Global Reference for Human Genetic Variation.” Nature 526 (7571): 68–74.