Deriving structural explanations for protein thermal stability using temperature sensitive mutants

Paper | Poster

Final Year Project for Biocheminstry degree at Imperial College London looking into which kinds of structural changes account for protein instability.

Getting Started

Programs used

• Missense3D - A binary classifier of disease causing mutants and structural changes
• FoldX - Predictor of changes in folding dG upon a point mutantion

Prerequisites used

Python packages used for this project

matplotlib
pandas
numpy
biopython

Author

• Charles Harris - cch1999 - ch5417@ic.ac.uk

License

Distributed under the MIT License. See LICENSE for more information.

Acknowledgments

• The author would like to acknowledge the help and supervision of Prof Michael Sternberg and Dr Suhail Islam during this project.