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Collabration with Andrew. Model's coding for TNF regulation in LPS, CpG and PIC

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Compuational modeling regulation of TNF cytokine secretion

Model's codes for paper (Gene & Dev. 2014, v28, pg2120, Network dynamics determine the autocrine and paracrine signaling functions of TNF), which simulated TNF regulation in LPS, CpG and PIC treatement.

Results

1. TRIF stabilize TNF mRNA

  • Increase the stability by 3.5 fold.

2. MyD88 is critical for TNF transcription

  • Open the chromatin for NFkB binding.

3. Different processing

  • MyD88 contributes more than TRIF in TNF mRNA processing (about 3 fold higher)

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Collabration with Andrew. Model's coding for TNF regulation in LPS, CpG and PIC

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