benjacobs123456/MS_UKB_PRS
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This repository contains key scripts used to generate the results in our paper: https://nn.neurology.org/content/8/4/e1007 The autosomal genetic risk score was created by running the following (in order): 1. ms_prs_stage1.sh (or ms_prs_stage1_mhc.sh for the MHC score) 2. ms_prs_stage2.sh 3. ms_prs_stage3.sh 4. ms_prs_stage4.sh 5. ms_prs_stage5.r The script ukb_convert_pheno_stage3.r was used to define disease variables from ICD codes and self-report, and to define HLA alleles from impute HLA data. Details of the main analyses in the paper are in ukb_case_control_16_02.r. Please email b.jacobs@qmul.ac.uk if you have any questions or suggestions. Ben Jacobs 24/11/21
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