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Update index, add popDMS paper
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johnbarton committed Feb 16, 2024
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# Lab overview

I'm an Associate Professor in the [Department of Computational and Systems Biology](https://www.csb.pitt.edu/) at the [University of Pittsburgh School of Medicine](https://www.medschool.pitt.edu/). My group studies how viruses evolve and interact with the immune system. Increasingly, we're also interested in general quantitative studies of evolution. Much of our work focuses on statistical inference, where we develop theoretical and computational methods to learn as much as we can from data. Our goal is to improve our understanding of evolving pathogens, and ultimately to develop better therapies and vaccines to fight against them. We work closely with a variety of collaborators, from mathematicians and theoretical physicists to immunologists, virologists, and microbiologists. You can read more about our research interests on the [research page](research.md).
I'm an Associate Professor in the [Department of Computational and Systems Biology](https://www.csb.pitt.edu/) at the [University of Pittsburgh School of Medicine](https://www.medschool.pitt.edu/). My lab's overarching mission is to help solve problems that will improve how we prevent and treat disease. Our primary biological focus is on evolution, especially the evolution of viral pathogens, and immunity. We work closely with a variety of collaborators, from mathematicians and theoretical physicists to immunologists, virologists, and microbiologists. You can read more about our research interests on the [research page](research.md).

I graduated from Duke University with degrees in Physics and Mathematics, and completed my PhD in Physics with [Joel Lebowitz](https://www.sas.rutgers.edu/cms/math/people-cmsr/faculty-profiles-cmsr/63-lebowitz-joel) at Rutgers University. I did my postdoctoral work in the interdisciplinary lab of [Arup Chakraborty](https://web.mit.edu/akcgroup/) in the [Institute for Medical Engineering and Science](https://imes.mit.edu/) at MIT. Before moving to Pitt, I was an Assistant Professor in the [Department of Physics and Astronomy](https://physics.ucr.edu/) at the [University of California, Riverside](https://www.ucr.edu/).

# Contact

830 Murdoch Building<br>
3420 Forbes Avenue<br>
Pittsburgh, PA 15260<br>
Pittsburgh, PA 15213<br>

jpbarton@pitt.edu
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**Key papers**

<small><b>Inferring effects of mutations on SARS-CoV-2 transmission from genomic surveillance data</b><br>Lee B, Sohail MS, Finney E, Ahmed SF, Quadeer AA, McKay MR, <b>Barton JP</b><br>medRxiv [[journal link]](https://doi.org/10.1101/2021.12.31.21268591) [[pdf]](assets/pdf/papers/lee-sc2-transmission.pdf) [[code]](https://github.com/bartonlab/paper-SARS-CoV-2-inference)</small>
<small><b>Inferring effects of mutations on SARS-CoV-2 transmission from genomic surveillance data</b><br><b>Lee B</b>, Sohail MS, <b>Finney E</b>, Ahmed SF, Quadeer AA, McKay MR, <b>Barton JP</b><br>medRxiv [[journal link]](https://doi.org/10.1101/2021.12.31.21268591) [[pdf]](assets/pdf/papers/lee-sc2-transmission.pdf) [[code]](https://github.com/bartonlab/paper-SARS-CoV-2-inference)</small>

<small><b>MPL resolves genetic linkage in fitness inference from complex evolutionary histories</b><br>Sohail MS<sup>=</sup>, Louie RH<sup>=</sup>, McKay MR<sup>c</sup>, <b>Barton JP</b><sup>c</sup><br>Nature Biotechnology, 2021 [[journal link]](https://doi.org/10.1038/s41587-020-0737-3) [[pdf]](assets/pdf/papers/sohail-mpl.pdf) [[si]](assets/pdf/papers/sohail-mpl-si.pdf) [[code]](https://github.com/bartonlab/paper-MPL-inference)</small>

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**Key papers**

<small><b>Inferring effects of mutations on SARS-CoV-2 transmission from genomic surveillance data</b><br>Lee B, Sohail MS, Finney E, Ahmed SF, Quadeer AA, McKay MR, <b>Barton JP</b><br>medRxiv [[journal link]](https://doi.org/10.1101/2021.12.31.21268591) [[pdf]](assets/pdf/papers/lee-sc2-transmission.pdf) [[code]](https://github.com/bartonlab/paper-SARS-CoV-2-inference)</small>
<small><b>Inferring effects of mutations on SARS-CoV-2 transmission from genomic surveillance data</b><br><b>Lee B</b>, Sohail MS, <b>Finney E</b>, Ahmed SF, Quadeer AA, McKay MR, <b>Barton JP</b><br>medRxiv [[journal link]](https://doi.org/10.1101/2021.12.31.21268591) [[pdf]](assets/pdf/papers/lee-sc2-transmission.pdf) [[code]](https://github.com/bartonlab/paper-SARS-CoV-2-inference)</small>

<small><b>popDMS infers mutation effects from deep mutational scanning data</b><br><b>Hong Z</b>, <b>Barton JP</b><br>bioRxiv [[journal link]](https://www.biorxiv.org/content/10.1101/2024.01.29.577759) [[pdf]](assets/pdf/papers/hong-popdms.pdf) [[code]](https://github.com/bartonlab/paper-DMS-inference)</small>

<small><b>MPL resolves genetic linkage in fitness inference from complex evolutionary histories</b><br>Sohail MS<sup>=</sup>, Louie RH<sup>=</sup>, McKay MR<sup>c</sup>, <b>Barton JP</b><sup>c</sup><br>Nature Biotechnology, 2021 [[journal link]](https://doi.org/10.1038/s41587-020-0737-3) [[pdf]](assets/pdf/papers/sohail-mpl.pdf) [[si]](assets/pdf/papers/sohail-mpl-si.pdf) [[code]](https://github.com/bartonlab/paper-MPL-inference)</small>

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