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Flatiron Capstone; Computer Vision model to identify tablets and capsules in pursuit of improving medication safety. Modeled with densely-connected, convolutional neural network, and CNN with transfer learning (VGG16) models;

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Increasing Medication Safety with Deep Learning Image Recognition

Overview

Despite increases in healthcare spending and tremendous advances in technology in the last several decades, medication errors and injury/morbity from errors have continued to increase. The abuse of opiods have certainly contributed to mortality from medication overdoses, but the vast majority of Adverse Drug Events occur from patients taking medications as prescribed. The RxVision project attempts to use deep learning in an image recognition model to identify medications and propose deployment solutions to reduce the risk and occurence of medication error, and, ultimately, the human and financial cost of an Adverse Medical Reaction.

Using the MobileDeepPill model as a benchmark, we aim to initially achieve 50% accuracy and work towards the 97% the MDP team reached.

Model Results as of 5/28/20:

Validation Accuracy: 93%

Real World Accuracy: ~50%

Repository Navigation

Technical Notebook : Technical Notebook 
Other Notebooks    : Modeling, Data Collection Notebook 
Dataset Links      : NIH RxImage Portal
Presentation       : Slide Deck, Google Slides

ReadME Navigation

Problem - Data - Model - Results - Recommendations - Future - Project Info - Works Cited

Problem

Americans are taking more medications than ever. In 2019, more than 4 billion prescriptions were dispensed in retail and mail-order pharmacies at a cost of $551 billion[kff]. This is in sharp contrast to the 3 billion prescriptions and $117 billion spent in 2000. Across all demographics, 89% of Americans take at least one daily medication, while 29% are taking 5 or more. Per capita, we've gone from 10.8 presctions in 2000 to in 11.9 in 2019.

These data are skewed when chronic, costly conditions are considered. Having multiple chronic conditions leads to not only more medications but more contraindicated medicines and treatments for side-effects. For example, patients treated for diabetes take 4 times as many medications as those not recieing diabetes treatment[gw]. Another major driver of prescription use increase is the aging population; about 52 million Americans are of age 65 or older and taking the lions share of medications.

When considering this growth, it becomes more clear why medical/medication error would be identified as the third leading cause of death in the US in 2016. As patients take more medications and drugs become more potent and complex, the risk of interactions, side effects, and errors increase as well.

The FDA provides guidance for defining, monitoring, and enforcing practices to reduce medical and medication errors.

Medication Error: Any preventable event that may cause or lead to inappropriate medication use or patient harm while the medication is in the control of the healthcare professional, patient, or consumer.

Adverse Medical Event (ADE): Any abnormal sign, symptom or laboratory test, or any syndromic combination of such abnormalities, any untoward or unplanned occurrence (e.g. an accident or unplanned pregnancy), or any unexpected deterioration in a concurrent illness

Adverse Medical Reaction (ADR): an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product.

Fig.1 - Medication Errors and Adverse Events.

Fig.1 - Medication Errors and Adverse Events.

When an ADE is identified, the course of action is clinical intervention with the patient and, if occurring in a clinical setting, reporting and correction action with the offending agency. However, as seen in the above graphic, not all ADEs are caused by medication error, and not all medication errors lead to an ADE or ADR. RxVision is certainly not the first pursuit of improvement in medication safety; the FDA has rolled out programs, regulations, and research to:

  • Guide drug developers and manufacturers provide clearer reporting on drug ingredients, labeling, and manufacturing (not in scope of RxVision);
  • Help pharmacies reduce errors in dispensing and releasing medications;
  • Assist patients in understanding the therapy and complications of their medicines.

Computerized prescription management, automated dispensing systems, and online prescription ordering have made it easier to get the right medication to the right patient quickly and safely.But human error and negligence will supercede a technological bottleneck if best practices are not upheld. Examples of preventable medication error include:

  • Physician

    • Carelessly prescribe the wrong medication
  • Physician or Pharmacy

    • Give a patient the wrong dosage, unintentionally
    • Fail to take a history of the patient’s prescription drug use
    • Fail to warn of all risks associated with the medication
    • Dangerously mixed different prescription drugs
    • administering the wrong dosage of medication (i.e., too much or too little medication)
    • prescribing the patient a medication that the patient is allergic to
    • prescribing the patient a medication that interacts negatively with other medications that the patient is taking, and
    • failing to warn the patient of the common side effects of the medication.
  • Pharmacy

    • Give a patient an unintended medication
    • mislabeling the medication
    • administering the wrong medication to a patient

We will narrow our focus on ADEs caused by medication error at the pharmacy or patient level.

Patient Challenges

Patients still struggle with identifying their medications, and often resort to inconsistent and risky behaviors, like putting all of their medications in one bottle or failing to comply with complicated therapy out of frustration. In the event that a patient needs assistance identifying a medication, they can check an online resource (risky), ask a caregiver, who may or may not be able to assist, or a pharmacist. Pharmacists are tasked with looking up a pill description, which may be fruitless or untimely, and this is a miss in service for the immediate patient and those patients who need the pharmacists time for clinical questions about their therapy (side effects, alternatives, dosing, etc). Many patients do not track their presciptions by the National Drug Code (NDC) and may need assistance validating if their medication was included in a recall, and pharmacies are often innundated with these questions during major recall events.

Recommendation: Patient/Caregiver Support

A smartphone app to cross-reference an identified medication with a patients medication list would give them confidence and reduce the stress of managing their medications. Patients with visual impairment can be sure to distibguish between similar looking medications without needing to strain to identify imprints or scoring. Checking for the recall status of their medications will be effortless as well with this model readily available.

Ideally, the app implementation of this model would be localized to the smartphone; this way no Personal Health Information is transmitted and privacy can be assured.

Pharmacy Challenges

Pharmacies invest thousands and millions into their processes and techology stacks to ensure each order is filled accurately per the prescription and received by the designated patient or caregiver. Despite these efforts, medication errors still occur. Payroll hours have continued to drop due to increased competition and pharmacists find themselves taking on more administrative and retail tasks than they had previously, without the help of as many technicians. These pharmacists are under more stress to maintain safety and operate a profitable business, and this leads to fatigue and burnout, which leads to errors. A prescription released to the wrong patient or with the wrong drug is embarrassing, costly, and dangerous.

Recommendation: Dispensing Validation

To minimize risk, implementing an image recognition model into the dispensing workflow can identify if a bottle has been filled incorrectly before the pharmacist does their visual inspection. Mail-order pharmacies already use cameras to take an overhead snapshot of the filled bottle for later validation if a patient is concerned, but using an image recognition model can proactively catch misfills before they could become errors. High-volume chain retail pharmacies would also benefit by taking advantage of the model to avoid sending orders back to technicians for filling correctly.

Emergency Challenges

During medical emergencies, EMTs and nurses must work quickly to gather information about the patients symptoms, history, and medications.

Recommendation: Emergency Intervention

Pill Identification

We have identified projects and competitions challenging computer engineering teams and labs to create models and applications in pursuit of high-accuracy pill recognition. A major competition, and the spark to this project, was the National Library of Medicine's Pill Image Recognition Challenge in 2016. The winning team from Michigan State University produce MobileDeepPill (github), which was able to correctly identify medications from the 4000+ image set with up to 97% accuracy in certain tests. The team prioritized efficiency and privacy in designing their Android App and published their research and code openly. Other teams and competitions did not bear fruit in the form of scores or literature, so it may still be a novel area of research in pharma to be pursued. With the wide range of scores and no major implementation in production for patient or clinic use, we suspect performance, cost, or regulations are preventing using image recognition models for this purpose.

Data

The images for training were acquired from the NIH National Library of Medicine's FTP server; a python 3.X package ftplib was used to iterate through the folders using the provided directory flat file.

NDCs_%20Frequency%20of%20Image%20Counts-2.png File%20Types.png

Dataset:

  • Total Images: 131,271
  • Drug Classes: 4,864
  • Most Common Drug Image: Levothyroxine

RxVision:

  • Total Images: 490
  • Drug Classes: 15

classes.jpg

Model

The most successful model was a convolutional neural network boosted with transfer learning, using VGG16 as the foundation.

Results

Improving the current model

RxVision uses VGG16 to boost accuracy from training, however the real-world results do not reflect the validation accuracy. This means more images and more image augementation is required.

Future

RxVision%Future.png

More Medications

Once the real-world accuracy is above 90%, I would like to use RxVision to transfer learning to models for more medications

More Needs

I have a vision of the model serving many diverse groups of patients, including those addicted to opioids. To help opioid users avoid ingesting contaminated medications, I would like to make a model for distinguishing authentic from counterfeit medications.

A fascinating project in South Korea aimed to use image recognition on street recreational tablets with unique presses. Athough the constiution of such a drug could not be validated via image recognition, it could assist recreation drug users in avoid detrimental effects of potentialy tainted products.

Project Info

Contributors : Alphonso Woodbury
Languages    : Python
Tools/IDE    : Anaconda, Colab
Libraries    : Tensorflow, Keras, imagio, PIL, ftplib
Duration     : May 2020
Last Update  : 05.20.2020
Domain       : Computer Vision, Machine Learning
Sub-Domain   : Deep Learning, Image Recognition
Techniques   : Deep Convolutional Neural Network, 
Application  : Image Recognition, Image Classification

Works Cited

  1. Hopkins: Medical error third leading cause of death
  2. 3 Types of Medical Errors
  3. FDA: Reducing medical Errors
  4. WHO: Medication Errors
  5. WHO: Growing Threat from counterfeit medications
  6. Aging USA
  7. Adverse Drug Events
  8. CDC: Chronic Diseases
  9. Pill Image Recognition Challenge (2016)
  10. Reducing Medication Errors in Pediatrics
  11. A Similar Pill ID Project from Indiana University
  12. Automatic Drug image identification
  13. NLM RxImage API

Medication errors also have a financial toll. In response to these errors that lead to heath deficiency or death, malpractice suits have grown to account for 5% of... The average cost of an ADE is $2,257 (FDA 2004).

Adverse drug events cost the United States $37.6 billion each year, and approximately $17 billion of these costs are associated with preventable errors (Source: “To Error is Human: Building a Safer Health System,” a November 1999 report from the Institute of Medicine [IOM]).

The extra medical costs of treating drug-related injuries occurring in hospitals alone conservatively amount to $3.5 billion a year. This estimate does not take into account lost wages and productivity or additional healthcare costs (Source: “Preventing Medication Errors: Quality Chasm Series,” a July 2006 report from the IOM).

Medication errors are the source of 5% of malpractice claims (Byron J. Bailey. “Medical Liability Issues: Where Malpractice Claims Come From and How to Survive Them,” July 2002).

The average jury award for medication error cases is $636,844 (Jury Verdict Research, “2000 Current Award Trends in Personal Injury,” June 2001).

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Flatiron Capstone; Computer Vision model to identify tablets and capsules in pursuit of improving medication safety. Modeled with densely-connected, convolutional neural network, and CNN with transfer learning (VGG16) models;

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