pvjs-2.4.73

JavaScript-based diagram viewer (implemented) and editor (in-progress) intended for biological pathways. It uses SVG and HTML for rendering, the Mithril framework for code organization and BridgeDb for biological entity reference queries.

Demo

• WikiPathways - Sandbox Pathway

How To Add It To Your Site

You can loading it with either one of the two options below: HTML Element or Script. It's as simple as referencing the pvjs JavaScript bundle and its dependencies in your HTML document:

Load Using Custom HTML Element

<wikipathways-pvjs
    alt="WP525 Biological Pathway"
    src="http://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=gpml&pwTitle=Pathway:WP525"
    display-errors="true"
    display-warnings="true"
    fit-to-container="true">
</wikipathways-pvjs>

<script src="//wikipathways.github.io/pvjs/lib/pvjs/pvjs-polyfills-2.3.5.bundle.min.js"></script>
<script src="//cdnjs.cloudflare.com/ajax/libs/d3/3.5.5/d3.min.js"></script>
<script src="//cdnjs.cloudflare.com/ajax/libs/jquery/1.11.1/jquery.min.js"></script>
<script src="//wikipathways.github.io/pvjs/lib/pvjs/pvjs-2.4.73.bundle.min.js"></script>

Load Using Script

First reference the pvjs JavaScript bundle and its dependencies in your HTML document:

<script src="//wikipathways.github.io/pvjs/lib/pvjs/pvjs-polyfills-2.3.5.bundle.min.js"></script>
<script src="//cdnjs.cloudflare.com/ajax/libs/d3/3.5.5/d3.min.js"></script>
<script src="//cdnjs.cloudflare.com/ajax/libs/jquery/1.11.1/jquery.min.js"></script>
<script src="//wikipathways.github.io/pvjs/lib/pvjs/pvjs-2.4.73.bundle.min.js"></script>

If you have jQuery, then you may do:

$('#pvjs-container').pvjs({
  sourceData: [
    // at least one item required
    {
      uri:'http://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=gpml&pwTitle=Pathway:WP525',
      fileType:'gpml' // generally will correspond to filename extension
    },
    {
      uri:'http://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP525',
      fileType:'png'
    }
  ]
});

If you don't have jQuery and do not want to add it, then you may call pvjs directly and pass two arguments: container selector and options object.

pvjs('#pvjs-container', {
  sourceData: [
    // at least one item required
    {
      uri:'http://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=gpml&pwTitle=Pathway:WP525',
      fileType:'gpml' // generally will correspond to filename extension
    },
    {
      uri:'http://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP525',
      fileType:'png'
    }
  ]
});

For developers

If it's your first time working on pvjs, check out the Getting Started Guide.

Components

• Viewer
  • Notifications Plugin
  • Highlighter Plugin
  • DiffViewer Plugin
  • Annotations Panel
• Editor
• bridgedbjs

Available event messages

Event messages are namespaced and may be called with namespace or without. Namespace is defined by a dot: click.renderer. Triggering events without specifying a namespace will run both events with and without namespace (ex. trigger('click') will run both on('click') and on('click.renderer')). Listening on events without a namespace will run hooks event if an event with namespace was triggered (ex. on('click') will run on both trigger('click') and trigger('click.renderer')). In order to prevent running unwanted hooks it is better to namespace all events triggers and listeners.

List of available events through application (custom events may be added at any time):

• destroy.pvjs
• error.sourceData
• error.pvjson
• error.renderer
• rendered.renderer
• zoomed.renderer
• panned.renderer
• warning.renderer

Editor Plugin

Allows for updating the pvjson data.

Notifications Plugin

Notifications plugin listens for warning and error messages and displays them as alert boxes.

Usage

In order to add notifications to pvjs do:

1. Reference plugin's JS and CSS files or use bundle version of pvjs

2. Activate notifications for a given pvjs:

   pvjsNotifications(pvjsInstance, {displayErrors: true, displayWarnings: true})

Highlighter Plugin

Highlighter plugin allows for highlighting pathway nodes, interactions, groups and other entities. It allows for selecting data nodes using autocomplete text input.

Usage

    $('#wikipathways-pvjs-1').pvjs({
      fitToContainer: true,
      sourceData: [
        // at least one item required
        {
          uri: '../input-data/WP525_73040.gpml',
          fileType: 'gpml' // generally will correspond to filename extension
        },
        {
          uri: 'http://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP1',
          fileType: 'biopax'
        },
        {
          uri: 'http://www.wikipathways.org//wpi/wpi.php?action=downloadFile&type=png&pwTitle=Pathway:WP1',
          fileType: 'png'
        }
      ],
      displayErrors: true,
      displayWarnings: true,
      highlights: [
        {
          selector: 'ATFS-1',
          backgroundColor: 'yellow',
          borderColor: 'blue',
        },
        {
          selector: 'PHB-2',
          backgroundColor: 'white',
          borderColor: 'red',
        }
      ]
    });

To highlight or attenuate call corresponding API methods:

// Highlight by ID
pathInstance.highlight('#e6e')
// Highlight by text label
pathInstance.highlight('Cholesterol')
// Highlight by xref
pathInstance.highlight('xref:12345')

// Attenuate by ID
pathInstance.attenuate('#e6e')

You can create highlight groups. This is useful if you want to namespace highlighters for easier attenuation.

// Default group
pathInstance.highlight('#e6e')

// Group g1
pathInstance.highlight('#e7e', 'g1')
pathInstance.highlight('#e8b', 'g1')
pathInstance.highlight('#e9c', 'g1')

// One highlighting can be part of more groups
pathInstance.highlight('#e7e', 'g2')

// Attenuate #e7e only if it is in group g2
pathInstance.attenuate('#e7e', 'g2')

// Attenuate all elements from group g1
pathInstance.attenuate(null, 'g1')

You may provide a custom style to your highlighting

// Red fill, blue stroke
pathInstance.highlight('#e6e', null, {fill: 'red', stroke: 'blue'})

Difference Viewer Plugin (DiffViewer)

DiffViewer plugin allows to compare difference between 2 different versions of a pathway.

Usage

First reference plugin's JS and CSS files or use bundle version of pvjs.

Highlighter should be instantiated before pvjs was rendered:

$('#pvjs-container').pvjs({
  fitToContainer: true,
  manualRender: true,
  sourceData: [
    {
      uri: 'http://pointer.ucsf.edu/d3/r/data-sources/gpml.php?id=WP2806&rev=75308',
      fileType:'gpml'
    }
  ]
});

// Get first element from array of instances
pathInstance = $('#pvjs-container').pvjs('get').pop();

// Init difference viewer
pvjsDiffviewer(pathInstance, {
  sourceData: [
    {
      uri: 'http://pointer.ucsf.edu/d3/r/data-sources/gpml.php?id=WP2806',
      fileType:'gpml'
    }
  ]
});

// Call renderer
pathInstance.render();

Related

This project is supported by the same community that maintains the Java-based pathway diagram editor PathVisio, but the codebases between pvjs and PathVisio-Java are entirely distinct. PathVisio-Java plugins will not work with pvjs.

License

Licensed under the Apache License, Version 2.0 (the "License"); you may not use this file except in compliance with the License. You may obtain a copy of the License at

   http://www.apache.org/licenses/LICENSE-2.0

Unless required by applicable law or agreed to in writing, software distributed under the License is distributed on an "AS IS" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. See the License for the specific language governing permissions and limitations under the License.

Funding

• The National Institute for General Medical Sciences R01-GM100039
• The BioRange program of the Netherlands Bioinformatics Centre
• University Maastricht: Broad Research Strategy Program Part 2 (BOS2)