Merge pull request #1 from SuLab/main

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SuLab · Dec 4, 2021 · b1eeba2 · b1eeba2
2 parents 7fe4aa3 + 3b1a5e0
commit b1eeba2
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Showing 3 changed files with 125 additions and 47 deletions.
diff --git a/indication_paths.json b/indication_paths.json
@@ -289429,5 +289429,81 @@
     "reference": [
       "https://go.drugbank.com/drugs/DB09462"
     ]
+  },
+  {
+    "directed": true,
+    "graph": {
+      "_id": "DB00715_MESH_D013313_1",
+      "disease": "Posttraumatic stress disorder",
+      "disease_mesh": "MESH:D013313",
+      "drug": "paroxetine",
+      "drug_mesh": "MESH:D017374",
+      "drugbank": "DB:DB00715"
+    },
+    "links": [
+      {
+        "key": "decreases activity of",
+        "source": "MESH:D017374",
+        "target": "UniProt:P31645"
+      },
+      {
+        "key": "positively regulates",
+        "source": "UniProt:P31645",
+        "target": "GO:0051610"
+      },
+      {
+        "key": "decreases abundance of",
+        "source": "GO:0051610",
+        "target": "MESH:D012701"
+      },
+      {
+        "key": "positively correlated with",
+        "source": "MESH:D012701",
+        "target": "GO:0060096"
+      },
+      {
+        "key": "negatively correlated with",
+        "source": "GO:0060096",
+        "target": "MESH:D013313"
+      }
+    ],
+    "multigraph": true,
+    "nodes": [
+      {
+        "id": "MESH:D017374",
+        "label": "Drug",
+        "name": "Paroxetine"
+      },
+      {
+        "id": "UniProt:P31645",
+        "label": "Protein",
+        "name": "Sodium-dependent serotonin transporter"
+      },
+      {
+        "id": "GO:0051610",
+        "label": "BiologicalProcess",
+        "name": "Serotonin uptake"
+      },
+      {
+        "id": "MESH:D012701",
+        "label": "ChemicalSubstance",
+        "name": "Serotonin"
+      },
+      {
+        "id": "GO:0060096",
+        "label": "BiologicalProcess",
+        "name": "Serotonin secretion, neurotransmission"
+      },
+      {
+        "id": "MESH:D013313",
+        "label": "Disease",
+        "name": "Posttraumatic stress disorder"
+      }
+    ],
+    "reference": [
+      "https://go.drugbank.com/drugs/DB00715#BE0000749",
+      "https://drugs.ncats.io/drug/41VRH5220H",
+      "https://en.wikipedia.org/wiki/Post-traumatic_stress_disorder"
+    ]
   }
 ]
diff --git a/indication_paths.yaml b/indication_paths.yaml
@@ -181937,3 +181937,51 @@
         name: Constipation
     reference:
     - https://go.drugbank.com/drugs/DB09462
+-   directed: true
+    graph:
+        _id: DB00715_MESH_D013313_1
+        disease: Posttraumatic stress disorder
+        disease_mesh: MESH:D013313
+        drug: paroxetine
+        drug_mesh: MESH:D017374
+        drugbank: DB:DB00715
+    links:
+    -   key: decreases activity of
+        source: MESH:D017374
+        target: UniProt:P31645
+    -   key: positively regulates
+        source: UniProt:P31645
+        target: GO:0051610
+    -   key: decreases abundance of
+        source: GO:0051610
+        target: MESH:D012701
+    -   key: positively correlated with
+        source: MESH:D012701
+        target: GO:0060096
+    -   key: negatively correlated with
+        source: GO:0060096
+        target: MESH:D013313
+    multigraph: true
+    nodes:
+    -   id: MESH:D017374
+        label: Drug
+        name: Paroxetine
+    -   id: UniProt:P31645
+        label: Protein
+        name: Sodium-dependent serotonin transporter
+    -   id: GO:0051610
+        label: BiologicalProcess
+        name: Serotonin uptake
+    -   id: MESH:D012701
+        label: ChemicalSubstance
+        name: Serotonin
+    -   id: GO:0060096
+        label: BiologicalProcess
+        name: Serotonin secretion, neurotransmission
+    -   id: MESH:D013313
+        label: Disease
+        name: Posttraumatic stress disorder
+    reference:
+    - https://go.drugbank.com/drugs/DB00715#BE0000749
+    - https://drugs.ncats.io/drug/41VRH5220H
+    - https://en.wikipedia.org/wiki/Post-traumatic_stress_disorder
diff --git a/submission.yaml b/submission.yaml
@@ -1,47 +1 @@
--   directed: true
-    graph:
-        disease: Posttraumatic stress disorder
-        disease_mesh: MESH:D013313
-        drug: paroxetine
-        drug_mesh: MESH:D017374
-        drugbank: DB:DB00715
-    links:
-    -   key: decreases activity of
-        source: MESH:D017374
-        target: UniProt:P31645
-    -   key: positively regulates
-        source: UniProt:P31645
-        target: GO:0051610
-    -   key: decreases abundance of
-        source: GO:0051610
-        target: MESH:D012701 
-    -   key: positively correlated with
-        source: MESH:D012701
-        target: GO:0060096
-    -   key: negatively correlated with
-        source: GO:0060096
-        target: MESH:D013313 
-    multigraph: true
-    nodes:
-    -   id: MESH:D017374
-        label: Drug
-        name: Paroxetine
-    -   id: UniProt:P31645
-        label: Protein
-        name: Sodium-dependent serotonin transporter
-    -   id: GO:0051610
-        label: BiologicalProcess
-        name: Serotonin uptake
-    -   id: MESH:D012701
-        label: ChemicalSubstance
-        name: Serotonin
-    -   id: GO:0060096
-        label: BiologicalProcess
-        name: Serotonin secretion, neurotransmission
-    -   id: MESH:D013313
-        label: Disease
-        name: Posttraumatic stress disorder
-    reference: 
-    - https://go.drugbank.com/drugs/DB00715#BE0000749
-    - https://drugs.ncats.io/drug/41VRH5220H
-    - https://en.wikipedia.org/wiki/Post-traumatic_stress_disorder
+