Quinidine-DDGI-Model

Model of published clinical quinidine drug-drug-(gene) interactions, where quinidine either acts as perpetrator or as victim

Repository files

A whole-body PBPK model of quinidine, evaluated within a comprehensive CYP2D6-CYP3A4-P-gp DD(G)I modeling network is provided, including in total 13 compounds. The model snapshot contains simulations of the clinical interaction studies used during model development, including the respective observed data digitized from literature reports. For further details, please refer to [1].

Version information

OSP Version 11.0

License

The model is distributed under the GPLv2 License.

Reference

[1] Feick D, Rüdesheim S, Marok FZ, Selzer D, Loer HLH, Teutonico D, Frechen S, van der Lee M, Moes DJAR, Swen JJ, Schwab M, Lehr T. Physiologically-based pharmacokinetic modeling of quinidine to establish a CYP3A4, P-gp, and CYP2D6 drug–drug–gene interaction network. CPT Pharmacometrics Syst Pharmacol 2023. DOI: 10.1002/psp4.12981.