Reconstruct a Transcriptional Regulatory Network using the principle of Maximum Entropy.
PlogP_TRN implements a regulatory network reconstruction method based on a method proposed by T.R. Lezon et al. Using the principle of entropy maximization to infer genetic interaction networks from gene expression patterns, PNAS, 2006, 103(50):19033-19038 doi:10.1073/pnas.0609152103.
Briefly, the method is based on finding where
are the observed gene expression values by maximizing the Shannon entropy:
which leads to a Boltzmann(-ish) distribution:
where is the "interaction strength" between genes i and j.
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