/
Heyde-et-al-2021-Mathematica.nb
6854 lines (6810 loc) · 293 KB
/
Heyde-et-al-2021-Mathematica.nb
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
671
672
673
674
675
676
677
678
679
680
681
682
683
684
685
686
687
688
689
690
691
692
693
694
695
696
697
698
699
700
701
702
703
704
705
706
707
708
709
710
711
712
713
714
715
716
717
718
719
720
721
722
723
724
725
726
727
728
729
730
731
732
733
734
735
736
737
738
739
740
741
742
743
744
745
746
747
748
749
750
751
752
753
754
755
756
757
758
759
760
761
762
763
764
765
766
767
768
769
770
771
772
773
774
775
776
777
778
779
780
781
782
783
784
785
786
787
788
789
790
791
792
793
794
795
796
797
798
799
800
801
802
803
804
805
806
807
808
809
810
811
812
813
814
815
816
817
818
819
820
821
822
823
824
825
826
827
828
829
830
831
832
833
834
835
836
837
838
839
840
841
842
843
844
845
846
847
848
849
850
851
852
853
854
855
856
857
858
859
860
861
862
863
864
865
866
867
868
869
870
871
872
873
874
875
876
877
878
879
880
881
882
883
884
885
886
887
888
889
890
891
892
893
894
895
896
897
898
899
900
901
902
903
904
905
906
907
908
909
910
911
912
913
914
915
916
917
918
919
920
921
922
923
924
925
926
927
928
929
930
931
932
933
934
935
936
937
938
939
940
941
942
943
944
945
946
947
948
949
950
951
952
953
954
955
956
957
958
959
960
961
962
963
964
965
966
967
968
969
970
971
972
973
974
975
976
977
978
979
980
981
982
983
984
985
986
987
988
989
990
991
992
993
994
995
996
997
998
999
1000
(* Content-type: application/vnd.wolfram.mathematica *)
(*** Wolfram Notebook File ***)
(* http://www.wolfram.com/nb *)
(* CreatedBy='Mathematica 11.3' *)
(*CacheID: 234*)
(* Internal cache information:
NotebookFileLineBreakTest
NotebookFileLineBreakTest
NotebookDataPosition[ 158, 7]
NotebookDataLength[ 300309, 6846]
NotebookOptionsPosition[ 299112, 6819]
NotebookOutlinePosition[ 299454, 6834]
CellTagsIndexPosition[ 299411, 6831]
WindowFrame->Normal*)
(* Beginning of Notebook Content *)
Notebook[{
Cell[TextData[StyleBox["Mathematica code for :\n \n Alexander Heyde, David \
Rohde, Cameron S. McAlpine, Shuang Zhang, Friedrich F. Hoyer, Jeffrey M. \
Gerold, David Cheek, Yoshiko Iwamoto, Maximilian J. Schloss, Katrien \
Vandoorne, Oriol Iborra - Egea, Christian Mu\[NTilde]oz - Guijosa, Antoni \
Bayes - Genis, Johannes G. Reiter, Morgan Craig, Filip K. Swirski, Matthias \
Nahrendorf, Martin A. Nowak, Kamila Naxerova. \n \n Increased stem cell \
proliferation in atherosclerosis accelerates clonal hematopoiesis.\n ", \
"Text"]], "Input",
PageWidth->WindowWidth,
CellChangeTimes->{{3.8189240078572097`*^9, 3.8189241160262766`*^9}, {
3.8189241522317686`*^9, 3.8189242585029964`*^9}, {3.8189243034072447`*^9,
3.818924380058028*^9}, {3.818924422142508*^9, 3.818924487007905*^9}, {
3.8189245196045203`*^9, 3.818924520344744*^9}, {3.818924561133058*^9,
3.8189245639787235`*^9}, {3.8189307425295815`*^9, 3.8189307524099236`*^9}, {
3.8189309858515463`*^9, 3.818930998545224*^9}, {3.818966248541712*^9,
3.818966259059514*^9}},ExpressionUUID->"6b105010-5e56-4ec7-a981-\
2e09be127bfa"],
Cell[CellGroupData[{
Cell[BoxData[
RowBox[{
RowBox[{"(*",
RowBox[{"Table", " ",
RowBox[{"S2", ":", " ",
RowBox[{"Human", " ", "model", " ", "parameters"}]}]}], "*)"}],
"\[IndentingNewLine]",
RowBox[{"(*",
RowBox[{"All", " ", "time", " ", "measurements", " ", "in", " ", "years"}],
"*)"}], "\[IndentingNewLine]",
RowBox[{
RowBox[{
RowBox[{"b", "=",
RowBox[{"365", "/", "28"}]}], ";", " ",
RowBox[{"(*",
RowBox[{
"Average", " ", "baseline", " ", "HSC", " ", "proliferation", " ",
"rate"}], "*)"}], "\[IndentingNewLine]",
RowBox[{"T", "=", "40"}], ";", " ",
RowBox[{"(*",
RowBox[{
"Age", " ", "of", " ", "onset", " ", "for", " ", "elevated", " ", "HSC",
" ", "proliferation", " ", "rate"}], "*)"}], "\[IndentingNewLine]",
RowBox[{"F", "=", ".02"}], ";", " ",
RowBox[{"(*",
RowBox[{"Detection", " ", "frequency", " ",
RowBox[{"(",
RowBox[{"minimum", " ", "VAF"}], ")"}]}], "*)"}],
"\[IndentingNewLine]",
RowBox[{"ts", "=", "50"}], ";", " ",
RowBox[{"(*",
RowBox[{
"Mean", " ", "age", " ", "of", " ", "baseline", " ", "VAF", " ",
"data"}], "*)"}], "\[IndentingNewLine]",
RowBox[{"fs", "=", ".0051"}], ";", " ",
RowBox[{"(*",
RowBox[{
RowBox[{
"Frequency", " ", "of", " ", "the", " ", "largest", " ", "driver", " ",
"clone", " ", "at", " ", "age", " ", "ts"}], "=",
RowBox[{"50", " ", "years"}]}], "*)"}], "\[IndentingNewLine]",
RowBox[{"s", "=", ".003"}], ";", " ",
RowBox[{"(*",
RowBox[{
"Selective", " ", "effect", " ", "of", " ", "the", " ", "largest", " ",
"driver", " ", "clone"}], "*)"}], "\[IndentingNewLine]",
RowBox[{"n", "=",
RowBox[{"10", "^", "4"}]}], ";", " ",
RowBox[{"(*",
RowBox[{"Number", " ", "of", " ", "HSCs"}], "*)"}],
"\[IndentingNewLine]", "\[IndentingNewLine]",
RowBox[{"(*",
RowBox[{"Figure", " ", "3",
RowBox[{"E", ":", " ",
RowBox[{"Driver", " ", "clone", " ", "expansion"}]}]}], "*)"}],
"\[IndentingNewLine]",
RowBox[{"Clear", "[", "R", "]"}], ";",
RowBox[{"t0", "=", "20"}], ";",
RowBox[{"tf", "=", "90"}], ";", " ",
RowBox[{"(*",
RowBox[{"Plot", " ", "window"}], "*)"}], "\[IndentingNewLine]",
RowBox[{"f0", "=",
RowBox[{".5", "/",
RowBox[{"(",
RowBox[{"1", "+",
RowBox[{
RowBox[{"(",
RowBox[{
RowBox[{".5", "/", "fs"}], "-", "1"}], ")"}], "*",
RowBox[{"Exp", "[",
RowBox[{"b", " ", "s", " ",
RowBox[{"(",
RowBox[{"ts", "-", "T"}], ")"}]}], "]"}]}]}], ")"}]}]}], ";"}],
"\[IndentingNewLine]",
RowBox[{"LogPlot", "[",
RowBox[{
RowBox[{
RowBox[{"{",
RowBox[{
RowBox[{
RowBox[{".5", "/",
RowBox[{"(",
RowBox[{"1", "+",
RowBox[{
RowBox[{"(",
RowBox[{
RowBox[{".5", "/", "f0"}], "-", "1"}], ")"}], "*",
RowBox[{"Exp", "[",
RowBox[{
RowBox[{"-", "b"}], " ", "s", " ",
RowBox[{"(",
RowBox[{"t", "-", "T"}], ")"}],
RowBox[{"(",
RowBox[{"1", "+",
RowBox[{
RowBox[{"(",
RowBox[{"R", "-", "1"}], ")"}], " ",
RowBox[{"HeavisideTheta", "[",
RowBox[{"t", "-", "T"}], "]"}]}]}], ")"}]}], "]"}]}]}],
")"}]}], "/.",
RowBox[{"R", "\[Rule]",
RowBox[{"{",
RowBox[{"3", ",", "2", ",", "1.5", ",", "1"}], "}"}]}]}], ",",
".02"}], "}"}], "//", "Evaluate"}], ",",
RowBox[{"{",
RowBox[{"t", ",", "t0", ",", "tf"}], "}"}], ",",
RowBox[{"PlotRange", "\[Rule]",
RowBox[{"{",
RowBox[{".001", ",", ".5"}], "}"}]}], ",",
RowBox[{"PlotLegends", "\[Rule]",
RowBox[{"{",
RowBox[{
"\"\<3x proliferation\>\"", ",", "\"\<2x proliferation\>\"", ",",
"\"\<1.5x proliferation\>\"", ",", "\"\<Healthy proliferation\>\"",
",", "\"\<Detection threshold\>\""}], "}"}]}], ",",
RowBox[{"AxesLabel", "\[Rule]",
RowBox[{"{",
RowBox[{"\"\<Patient age\>\"", ",", "\"\<Driver VAF\>\""}], "}"}]}]}],
"]"}]}]}]], "Input",
CellChangeTimes->{{3.8189245745434465`*^9, 3.8189247898855453`*^9}, {
3.818925108318907*^9, 3.8189251739196453`*^9}, {3.818925238241269*^9,
3.818925283520629*^9}, {3.818925324007826*^9, 3.818925358633783*^9}, {
3.8189253987693205`*^9, 3.81892551344436*^9}, {3.8189255573888874`*^9,
3.818925655055872*^9}, {3.818925729013533*^9, 3.8189257395817113`*^9}, {
3.8189257782896566`*^9, 3.818925790939472*^9}, {3.8189258584462566`*^9,
3.8189258692125025`*^9}, {3.818925911156972*^9, 3.818925911998814*^9}, {
3.8189262258561716`*^9, 3.8189262260646453`*^9}, {3.8189262751018887`*^9,
3.8189263868517275`*^9}, {3.818926459763856*^9, 3.8189265008047748`*^9}, {
3.8189265621319876`*^9, 3.818926681638734*^9}, {3.8189277276851234`*^9,
3.818927729087328*^9}, {3.8189279189981627`*^9, 3.8189280634147816`*^9}, {
3.8189285823067493`*^9, 3.818928605774102*^9}, {3.8189295344009404`*^9,
3.8189295362581263`*^9}, 3.818930618869459*^9, {3.818930827136959*^9,
3.818930859051365*^9}, {3.8189309459093904`*^9, 3.8189309595458345`*^9},
3.8189326054628396`*^9, {3.818932690684633*^9, 3.8189327012651663`*^9}, {
3.818966109642731*^9, 3.818966153974494*^9}, {3.818966726725415*^9,
3.8189667390707083`*^9}, {3.818966770245532*^9, 3.818966772933318*^9}, {
3.8189668646696196`*^9,
3.818966867301078*^9}},ExpressionUUID->"277ef787-3d43-424d-a183-\
5f3c7a90c042"],
Cell[BoxData[
TemplateBox[{GraphicsBox[{{{{}, {},
TagBox[{
Directive[
Opacity[1.],
RGBColor[0.368417, 0.506779, 0.709798],
AbsoluteThickness[1.6]],
LineBox[CompressedData["
1:eJwVjn0s1HEcgE95S0qG7/1+bVIRokY5dEM++kapaIyUkFjUFJXOvPWyXsYq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"]],
LineBox[CompressedData["
1:eJwBQQS++yFib1JlAgAAAEMAAAACAAAAbtu2bdsCREDtItNgm6cWwKwEAlqU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"]]}, Annotation[#, "Charting`Private`Tag$2702#1"]& ],
TagBox[{
Directive[
Opacity[1.],
RGBColor[0.880722, 0.611041, 0.142051],
AbsoluteThickness[1.6]],
LineBox[CompressedData["
1:eJwVjn0s1HEcgE95S0qG7/1+bVIRokY5dEM++kapaIyUkFjUFJXOvPWyXsYq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"]],
LineBox[CompressedData["
1:eJwVinsw1AkcwH+7WMprX5bEsW3XIDfnkbfyLWuxIrv4MfY4d0JIRK1jDetR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"]]}, Annotation[#, "Charting`Private`Tag$2702#1"]& ],
TagBox[{
Directive[
Opacity[1.],
RGBColor[0.560181, 0.691569, 0.194885],
AbsoluteThickness[1.6]],
LineBox[CompressedData["
1:eJwVjn0s1HEcgE95S0qG7/1+bVIRokY5dEM++kapaIyUkFjUFJXOvPWyXsYq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"]],
LineBox[CompressedData["
1:eJwBAQT++yFib1JlAgAAAD8AAAACAAAAbtu2bdsCRED0by0/8KgWwKwEAlqU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"]]}, Annotation[#, "Charting`Private`Tag$2702#1"]& ],
TagBox[{
Directive[
Opacity[1.],
RGBColor[0.922526, 0.385626, 0.209179],
AbsoluteThickness[1.6]],
LineBox[CompressedData["
1:eJwVjn0w1Hkcx7fNrbT57vOTI8n1cHRTxsbKyoeiNnlauz9NSV2spw1FiN0r
PU9dSU8qPcrJRHV6vBXqY2JlNVKjK3WJW9LNFuVqtjx17o/3vP56zevtsi5d
qaHTaLTQ8f3PNxVWEY0mhZFq7xeqJgnOLRfztn4nhbRPpqxcowQ3l/qQsclS
4B/dyTnbKEG70zqbEYEU2ly1ir77Epxz4NsHq7sUZmsZNbkowYx0W9NAtBSm
tOnLzlZLcMxTpH/9uxSO2JQef1spQUGdV9fdNfNhbV7loL5Qgt6siW95r7xg
erT542S1BDsby+pdA2RQW9UP+53G/7hdO+R91gcOc77az+oTY2aroqRb7AtT
q5mW2ZfFKH9m2B6cJwcx89w7pywxfnG+VRrw1Q/ipp2foPMRY6zQoQY2+oOB
PrdocEyEZQY35WgiACSWiFc/EKGAcTBhxswA8PfZAR4HRPhgV6e54lkAWKuq
Ir+oRRgesy7m+q5AKPEafd7hLMK2J5c/7QxcBNTJzY9n9grxqO7vzzcHF0GW
8t/UhKtCjGzoFFZdWwznr+RP4WUK0RzH8vwpNQju2J+78lImRMN8d4OtYzDk
pmtPFdGFuLvcfvWVjmBobdJasUmAx0NeplTtWwKZ9zqKXhUKsORg+okty5ZC
xnCaQasWYL6brL6VoQAyRxYq+l6AF6wWpf62AvrXe9642cPHu/EJNp83LQNR
nviJ8RIfHW0eTm2ZGQIH3dpvmzL4GD6kkbo+DYFgRYHVIuejvtCYHHx4OSQf
+nJqF52PlhXcSU2BodASp9jEfshDVf0PRi49DNYy4ruFh3h4OF+7tasuDLKr
OY/8onnIzThTwkwNh67kQJnahYfGCS0f8wUR8MzEmP7+DRd/M8ub3NIiwNLr
mJ5VxcX3H5YWCxojoGHlJeZUHRc9w2SjGtdIKFi6sX55ABeLF5/ha3SR4LKq
5X0Kk4tj+3prml9EAplhZPEfc3BHSqnolacSFvvf2HO5mIMZWcMbPH5VQkh3
t32ShoOxbV4rLf8ooaI24q9b7hxc39BnjQqMgs7C+qaPn9mYPUk/Y/qFKCh0
JWpjDRstORURHjQVnNw70aVhOxu35YfNG4hWgbtw1i9XQ9nI73h6jvuHCjoL
nnv68tn4wPTkfg9LDY+KrPFJdSzs60vutSaoYY0vrbZSxUK6uqdoQ6MacuTH
DAozQf9V7SPHnSjYNpbkW5tLcDa3+bSLMwXhiUJdbw5BdnOdvHIaBb6lzfdI
NsEur3L9XVcK1o4Erfg5g2A+N2+k50cKzKJbjQwtwfpm5xEPLwoyTPFHlDEE
F8m0wy1hFKQHtU/oX0hwzsCaU+oICrj71/WI/AjyL6p8X0dSwI5weBjgS7CH
t1A3qKJA0D658pg3wZ0D7GHxKgrSNrHK/eYRbLx4e0iTSEENp+xEgQvBq6sr
iweSxnsOUa0GZ4JF/PMLclPGfZPczuxEMGH73rz9qRQoqpoKvB0IMmJjhq5n
UjBS+vJ5F5dgPz+yWJ5FgWP/bhmTQ/DPlqAFxmwKgu1yzsxnEbzoMzevI5cC
+nK3nH1MggUfXB3idBSYcMBy045gdrn4zjs9BbYlY5rXtgRjY+1XZm+hoJu3
oteOQXCJgD70bSsFtTCaLLUh+B8Mfiuq
"]]}, Annotation[#, "Charting`Private`Tag$2702#1"]& ],
TagBox[{
Directive[
Opacity[1.],
RGBColor[0.528488, 0.470624, 0.701351],
AbsoluteThickness[1.6]],
LineBox[CompressedData["
1:eJxTTMoPSmViYGAwAWIQ/WzVd3Egz2G99Jrtl7z5D/wzFq+5vx7BF91r9mBf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"]]},
Annotation[#,
"Charting`Private`Tag$2702#2"]& ], {}}, {{}, {}, {}, {}, {}, {}, \
{}}}, {}, {}}, {Ticks -> {Automatic,
Charting`ScaledTicks[{Log, Exp}]}, GridLines -> {None, None},
FrameTicks -> {{
Charting`ScaledTicks[{Log, Exp}],
Charting`ScaledFrameTicks[{Log, Exp}]}, {Automatic, Automatic}},
DisplayFunction -> Identity,
Method -> {
"DefaultBoundaryStyle" -> Automatic, "DefaultMeshStyle" ->
AbsolutePointSize[6], "ScalingFunctions" -> None}, DisplayFunction ->
Identity, DisplayFunction -> Identity, Ticks -> {Automatic, Quiet[
Charting`ScaledTicks[{Log, Exp}][#, #2, {6, 6}]]& },
AxesOrigin -> {20.00000142857143, -6.907755278982137},
FrameTicks -> {{Quiet[
Charting`ScaledTicks[{Log, Exp}][#, #2, {6, 6}]]& ,
Charting`ScaledFrameTicks[{Log, Exp}]}, {Automatic,
Charting`ScaledFrameTicks[{Identity, Identity}]}},
GridLines -> {None, None}, DisplayFunction -> Identity,
PlotRangePadding -> {{
Scaled[0.02],
Scaled[0.02]}, {0, 0}}, PlotRangeClipping -> True, ImagePadding ->
All, DisplayFunction -> Identity,
Method -> {
"DefaultBoundaryStyle" -> Automatic, "DefaultMeshStyle" ->
AbsolutePointSize[6], "ScalingFunctions" -> None,
"ClippingRange" -> {{{20.00000142857143,
89.99999857142858}, {-6.444659623767162, -1.0343343985848241`}}, {{
20.00000142857143,
89.99999857142858}, {-6.444659623767162, -1.0343343985848241`}}}},
DisplayFunction -> Identity, AspectRatio ->
NCache[GoldenRatio^(-1), 0.6180339887498948], Axes -> {True, True},
AxesLabel -> {
FormBox["\"Patient age\"", TraditionalForm],
FormBox["\"Driver VAF\"", TraditionalForm]},
AxesOrigin -> {20.00000142857143, -6.907755278982137},
CoordinatesToolOptions -> {"DisplayFunction" -> ({
Part[#, 1],
Exp[
Part[#, 2]]}& ), "CopiedValueFunction" -> ({
Part[#, 1],
Exp[
Part[#, 2]]}& )}, DisplayFunction :> Identity,
Frame -> {{False, False}, {False, False}},
FrameLabel -> {{None, None}, {None, None}},
FrameTicks -> {{Automatic, Automatic}, {Automatic, Automatic}},
GridLines -> {None, None}, GridLinesStyle -> Directive[
GrayLevel[0.5, 0.4]],
Method -> {
"DefaultBoundaryStyle" -> Automatic, "DefaultMeshStyle" ->
AbsolutePointSize[6], "ScalingFunctions" -> None},
PlotRange -> {{20.00000142857143,
89.99999857142858}, {-6.907755278982137, -0.6931471805599453}},
PlotRangeClipping -> True, PlotRangePadding -> {{
Scaled[0.02],
Scaled[0.02]}, {Automatic, Automatic}},
Ticks -> {Automatic, Automatic}}],FormBox[
FormBox[
TemplateBox[{
"\"3x proliferation\"", "\"2x proliferation\"",
"\"1.5x proliferation\"", "\"Healthy proliferation\"",
"\"Detection threshold\""}, "LineLegend", DisplayFunction -> (FormBox[
StyleBox[
StyleBox[
PaneBox[
TagBox[
GridBox[{{
TagBox[
GridBox[{{
GraphicsBox[{{
Directive[
EdgeForm[
Directive[
Opacity[0.3],
GrayLevel[0]]],
PointSize[0.5],
Opacity[1.],
RGBColor[0.368417, 0.506779, 0.709798],
AbsoluteThickness[1.6]], {
LineBox[{{0, 10}, {20, 10}}]}}, {
Directive[
EdgeForm[
Directive[
Opacity[0.3],
GrayLevel[0]]],
PointSize[0.5],
Opacity[1.],
RGBColor[0.368417, 0.506779, 0.709798],
AbsoluteThickness[1.6]], {}}}, AspectRatio -> Full,
ImageSize -> {20, 10}, PlotRangePadding -> None,
ImagePadding -> Automatic,
BaselinePosition -> (Scaled[0.1] -> Baseline)], #}, {
GraphicsBox[{{
Directive[
EdgeForm[
Directive[
Opacity[0.3],
GrayLevel[0]]],
PointSize[0.5],
Opacity[1.],
RGBColor[0.880722, 0.611041, 0.142051],
AbsoluteThickness[1.6]], {
LineBox[{{0, 10}, {20, 10}}]}}, {
Directive[
EdgeForm[
Directive[
Opacity[0.3],
GrayLevel[0]]],
PointSize[0.5],
Opacity[1.],
RGBColor[0.880722, 0.611041, 0.142051],
AbsoluteThickness[1.6]], {}}}, AspectRatio -> Full,
ImageSize -> {20, 10}, PlotRangePadding -> None,
ImagePadding -> Automatic,
BaselinePosition -> (Scaled[0.1] -> Baseline)], #2}, {
GraphicsBox[{{
Directive[
EdgeForm[
Directive[
Opacity[0.3],
GrayLevel[0]]],
PointSize[0.5],
Opacity[1.],
RGBColor[0.560181, 0.691569, 0.194885],
AbsoluteThickness[1.6]], {
LineBox[{{0, 10}, {20, 10}}]}}, {
Directive[
EdgeForm[
Directive[
Opacity[0.3],
GrayLevel[0]]],
PointSize[0.5],
Opacity[1.],
RGBColor[0.560181, 0.691569, 0.194885],
AbsoluteThickness[1.6]], {}}}, AspectRatio -> Full,
ImageSize -> {20, 10}, PlotRangePadding -> None,
ImagePadding -> Automatic,
BaselinePosition -> (Scaled[0.1] -> Baseline)], #3}, {
GraphicsBox[{{
Directive[
EdgeForm[
Directive[
Opacity[0.3],
GrayLevel[0]]],
PointSize[0.5],
Opacity[1.],
RGBColor[0.922526, 0.385626, 0.209179],
AbsoluteThickness[1.6]], {
LineBox[{{0, 10}, {20, 10}}]}}, {
Directive[
EdgeForm[
Directive[
Opacity[0.3],
GrayLevel[0]]],
PointSize[0.5],
Opacity[1.],
RGBColor[0.922526, 0.385626, 0.209179],
AbsoluteThickness[1.6]], {}}}, AspectRatio -> Full,
ImageSize -> {20, 10}, PlotRangePadding -> None,
ImagePadding -> Automatic,
BaselinePosition -> (Scaled[0.1] -> Baseline)], #4}, {
GraphicsBox[{{
Directive[
EdgeForm[
Directive[
Opacity[0.3],
GrayLevel[0]]],
PointSize[0.5],
Opacity[1.],
RGBColor[0.528488, 0.470624, 0.701351],
AbsoluteThickness[1.6]], {
LineBox[{{0, 10}, {20, 10}}]}}, {
Directive[
EdgeForm[
Directive[
Opacity[0.3],
GrayLevel[0]]],
PointSize[0.5],
Opacity[1.],
RGBColor[0.528488, 0.470624, 0.701351],
AbsoluteThickness[1.6]], {}}}, AspectRatio -> Full,
ImageSize -> {20, 10}, PlotRangePadding -> None,
ImagePadding -> Automatic,
BaselinePosition -> (Scaled[0.1] -> Baseline)], #5}},
GridBoxAlignment -> {
"Columns" -> {Center, Left}, "Rows" -> {{Baseline}}},
AutoDelete -> False,
GridBoxDividers -> {
"Columns" -> {{False}}, "Rows" -> {{False}}},
GridBoxItemSize -> {"Columns" -> {{All}}, "Rows" -> {{All}}},
GridBoxSpacings -> {
"Columns" -> {{0.5}}, "Rows" -> {{0.8}}}], "Grid"]}},
GridBoxAlignment -> {"Columns" -> {{Left}}, "Rows" -> {{Top}}},
AutoDelete -> False,
GridBoxItemSize -> {
"Columns" -> {{Automatic}}, "Rows" -> {{Automatic}}},
GridBoxSpacings -> {"Columns" -> {{1}}, "Rows" -> {{0}}}],
"Grid"], Alignment -> Left, AppearanceElements -> None,
ImageMargins -> {{5, 5}, {5, 5}}, ImageSizeAction ->
"ResizeToFit"], LineIndent -> 0, StripOnInput -> False], {
FontFamily -> "Arial"}, Background -> Automatic, StripOnInput ->
False], TraditionalForm]& ),
InterpretationFunction :> (RowBox[{"LineLegend", "[",
RowBox[{
RowBox[{"{",
RowBox[{
RowBox[{"Directive", "[",
RowBox[{
RowBox[{"Opacity", "[", "1.`", "]"}], ",",
InterpretationBox[
ButtonBox[
TooltipBox[
GraphicsBox[{{
GrayLevel[0],
RectangleBox[{0, 0}]}, {
GrayLevel[0],
RectangleBox[{1, -1}]}, {
RGBColor[0.368417, 0.506779, 0.709798],
RectangleBox[{0, -1}, {2, 1}]}}, DefaultBaseStyle ->
"ColorSwatchGraphics", AspectRatio -> 1, Frame -> True,
FrameStyle ->
RGBColor[
0.24561133333333335`, 0.3378526666666667,
0.4731986666666667], FrameTicks -> None, PlotRangePadding ->
None, ImageSize ->
Dynamic[{
Automatic, 1.35 CurrentValue["FontCapHeight"]/
AbsoluteCurrentValue[Magnification]}]],
StyleBox[
RowBox[{"RGBColor", "[",
RowBox[{"0.368417`", ",", "0.506779`", ",", "0.709798`"}],
"]"}], NumberMarks -> False]], Appearance -> None,
BaseStyle -> {}, BaselinePosition -> Baseline,
DefaultBaseStyle -> {}, ButtonFunction :>
With[{Typeset`box$ = EvaluationBox[]},
If[
Not[
AbsoluteCurrentValue["Deployed"]],
SelectionMove[Typeset`box$, All, Expression];
FrontEnd`Private`$ColorSelectorInitialAlpha = 1;
FrontEnd`Private`$ColorSelectorInitialColor =
RGBColor[0.368417, 0.506779, 0.709798];
FrontEnd`Private`$ColorSelectorUseMakeBoxes = True;
MathLink`CallFrontEnd[
FrontEnd`AttachCell[Typeset`box$,
FrontEndResource["RGBColorValueSelector"], {
0, {Left, Bottom}}, {Left, Top},
"ClosingActions" -> {
"SelectionDeparture", "ParentChanged",
"EvaluatorQuit"}]]]], BaseStyle -> Inherited, Evaluator ->
Automatic, Method -> "Preemptive"],
RGBColor[0.368417, 0.506779, 0.709798], Editable -> False,
Selectable -> False], ",",
RowBox[{"AbsoluteThickness", "[", "1.6`", "]"}]}], "]"}],
",",
RowBox[{"Directive", "[",
RowBox[{
RowBox[{"Opacity", "[", "1.`", "]"}], ",",
InterpretationBox[
ButtonBox[
TooltipBox[
GraphicsBox[{{
GrayLevel[0],
RectangleBox[{0, 0}]}, {
GrayLevel[0],
RectangleBox[{1, -1}]}, {
RGBColor[0.880722, 0.611041, 0.142051],
RectangleBox[{0, -1}, {2, 1}]}}, DefaultBaseStyle ->
"ColorSwatchGraphics", AspectRatio -> 1, Frame -> True,
FrameStyle ->
RGBColor[
0.587148, 0.40736066666666665`, 0.09470066666666668],
FrameTicks -> None, PlotRangePadding -> None, ImageSize ->
Dynamic[{
Automatic, 1.35 CurrentValue["FontCapHeight"]/
AbsoluteCurrentValue[Magnification]}]],
StyleBox[
RowBox[{"RGBColor", "[",
RowBox[{"0.880722`", ",", "0.611041`", ",", "0.142051`"}],
"]"}], NumberMarks -> False]], Appearance -> None,
BaseStyle -> {}, BaselinePosition -> Baseline,
DefaultBaseStyle -> {}, ButtonFunction :>
With[{Typeset`box$ = EvaluationBox[]},
If[
Not[
AbsoluteCurrentValue["Deployed"]],
SelectionMove[Typeset`box$, All, Expression];
FrontEnd`Private`$ColorSelectorInitialAlpha = 1;
FrontEnd`Private`$ColorSelectorInitialColor =
RGBColor[0.880722, 0.611041, 0.142051];
FrontEnd`Private`$ColorSelectorUseMakeBoxes = True;
MathLink`CallFrontEnd[
FrontEnd`AttachCell[Typeset`box$,
FrontEndResource["RGBColorValueSelector"], {
0, {Left, Bottom}}, {Left, Top},
"ClosingActions" -> {
"SelectionDeparture", "ParentChanged",
"EvaluatorQuit"}]]]], BaseStyle -> Inherited, Evaluator ->
Automatic, Method -> "Preemptive"],
RGBColor[0.880722, 0.611041, 0.142051], Editable -> False,
Selectable -> False], ",",
RowBox[{"AbsoluteThickness", "[", "1.6`", "]"}]}], "]"}],
",",
RowBox[{"Directive", "[",
RowBox[{
RowBox[{"Opacity", "[", "1.`", "]"}], ",",
InterpretationBox[
ButtonBox[
TooltipBox[
GraphicsBox[{{
GrayLevel[0],
RectangleBox[{0, 0}]}, {
GrayLevel[0],
RectangleBox[{1, -1}]}, {
RGBColor[0.560181, 0.691569, 0.194885],
RectangleBox[{0, -1}, {2, 1}]}}, DefaultBaseStyle ->
"ColorSwatchGraphics", AspectRatio -> 1, Frame -> True,
FrameStyle ->
RGBColor[
0.37345400000000006`, 0.461046, 0.12992333333333334`],
FrameTicks -> None, PlotRangePadding -> None, ImageSize ->
Dynamic[{
Automatic, 1.35 CurrentValue["FontCapHeight"]/
AbsoluteCurrentValue[Magnification]}]],
StyleBox[
RowBox[{"RGBColor", "[",
RowBox[{"0.560181`", ",", "0.691569`", ",", "0.194885`"}],
"]"}], NumberMarks -> False]], Appearance -> None,
BaseStyle -> {}, BaselinePosition -> Baseline,
DefaultBaseStyle -> {}, ButtonFunction :>
With[{Typeset`box$ = EvaluationBox[]},
If[
Not[
AbsoluteCurrentValue["Deployed"]],
SelectionMove[Typeset`box$, All, Expression];
FrontEnd`Private`$ColorSelectorInitialAlpha = 1;
FrontEnd`Private`$ColorSelectorInitialColor =
RGBColor[0.560181, 0.691569, 0.194885];
FrontEnd`Private`$ColorSelectorUseMakeBoxes = True;
MathLink`CallFrontEnd[
FrontEnd`AttachCell[Typeset`box$,
FrontEndResource["RGBColorValueSelector"], {
0, {Left, Bottom}}, {Left, Top},
"ClosingActions" -> {
"SelectionDeparture", "ParentChanged",
"EvaluatorQuit"}]]]], BaseStyle -> Inherited, Evaluator ->
Automatic, Method -> "Preemptive"],
RGBColor[0.560181, 0.691569, 0.194885], Editable -> False,
Selectable -> False], ",",
RowBox[{"AbsoluteThickness", "[", "1.6`", "]"}]}], "]"}],
",",
RowBox[{"Directive", "[",
RowBox[{
RowBox[{"Opacity", "[", "1.`", "]"}], ",",
InterpretationBox[
ButtonBox[
TooltipBox[
GraphicsBox[{{
GrayLevel[0],
RectangleBox[{0, 0}]}, {
GrayLevel[0],
RectangleBox[{1, -1}]}, {
RGBColor[0.922526, 0.385626, 0.209179],
RectangleBox[{0, -1}, {2, 1}]}}, DefaultBaseStyle ->
"ColorSwatchGraphics", AspectRatio -> 1, Frame -> True,
FrameStyle ->
RGBColor[
0.6150173333333333, 0.25708400000000003`,
0.13945266666666667`], FrameTicks -> None,
PlotRangePadding -> None, ImageSize ->
Dynamic[{
Automatic, 1.35 CurrentValue["FontCapHeight"]/
AbsoluteCurrentValue[Magnification]}]],
StyleBox[
RowBox[{"RGBColor", "[",
RowBox[{"0.922526`", ",", "0.385626`", ",", "0.209179`"}],
"]"}], NumberMarks -> False]], Appearance -> None,
BaseStyle -> {}, BaselinePosition -> Baseline,
DefaultBaseStyle -> {}, ButtonFunction :>
With[{Typeset`box$ = EvaluationBox[]},
If[
Not[
AbsoluteCurrentValue["Deployed"]],
SelectionMove[Typeset`box$, All, Expression];
FrontEnd`Private`$ColorSelectorInitialAlpha = 1;
FrontEnd`Private`$ColorSelectorInitialColor =
RGBColor[0.922526, 0.385626, 0.209179];
FrontEnd`Private`$ColorSelectorUseMakeBoxes = True;
MathLink`CallFrontEnd[
FrontEnd`AttachCell[Typeset`box$,
FrontEndResource["RGBColorValueSelector"], {
0, {Left, Bottom}}, {Left, Top},
"ClosingActions" -> {
"SelectionDeparture", "ParentChanged",
"EvaluatorQuit"}]]]], BaseStyle -> Inherited, Evaluator ->
Automatic, Method -> "Preemptive"],
RGBColor[0.922526, 0.385626, 0.209179], Editable -> False,
Selectable -> False], ",",
RowBox[{"AbsoluteThickness", "[", "1.6`", "]"}]}], "]"}],
",",
RowBox[{"Directive", "[",
RowBox[{
RowBox[{"Opacity", "[", "1.`", "]"}], ",",
InterpretationBox[
ButtonBox[
TooltipBox[
GraphicsBox[{{
GrayLevel[0],
RectangleBox[{0, 0}]}, {
GrayLevel[0],
RectangleBox[{1, -1}]}, {
RGBColor[0.528488, 0.470624, 0.701351],
RectangleBox[{0, -1}, {2, 1}]}}, DefaultBaseStyle ->
"ColorSwatchGraphics", AspectRatio -> 1, Frame -> True,
FrameStyle ->
RGBColor[
0.3523253333333333, 0.3137493333333333,
0.46756733333333333`], FrameTicks -> None,
PlotRangePadding -> None, ImageSize ->
Dynamic[{
Automatic, 1.35 CurrentValue["FontCapHeight"]/
AbsoluteCurrentValue[Magnification]}]],
StyleBox[
RowBox[{"RGBColor", "[",
RowBox[{"0.528488`", ",", "0.470624`", ",", "0.701351`"}],
"]"}], NumberMarks -> False]], Appearance -> None,
BaseStyle -> {}, BaselinePosition -> Baseline,
DefaultBaseStyle -> {}, ButtonFunction :>
With[{Typeset`box$ = EvaluationBox[]},
If[
Not[
AbsoluteCurrentValue["Deployed"]],
SelectionMove[Typeset`box$, All, Expression];
FrontEnd`Private`$ColorSelectorInitialAlpha = 1;
FrontEnd`Private`$ColorSelectorInitialColor =
RGBColor[0.528488, 0.470624, 0.701351];
FrontEnd`Private`$ColorSelectorUseMakeBoxes = True;
MathLink`CallFrontEnd[
FrontEnd`AttachCell[Typeset`box$,
FrontEndResource["RGBColorValueSelector"], {
0, {Left, Bottom}}, {Left, Top},
"ClosingActions" -> {
"SelectionDeparture", "ParentChanged",
"EvaluatorQuit"}]]]], BaseStyle -> Inherited, Evaluator ->
Automatic, Method -> "Preemptive"],
RGBColor[0.528488, 0.470624, 0.701351], Editable -> False,
Selectable -> False], ",",
RowBox[{"AbsoluteThickness", "[", "1.6`", "]"}]}], "]"}]}],
"}"}], ",",
RowBox[{"{",
RowBox[{#, ",", #2, ",", #3, ",", #4, ",", #5}], "}"}], ",",
RowBox[{"LegendMarkers", "\[Rule]", "None"}], ",",
RowBox[{"LabelStyle", "\[Rule]",
RowBox[{"{", "}"}]}], ",",
RowBox[{"LegendLayout", "\[Rule]", "\"Column\""}]}], "]"}]& ),
Editable -> True], TraditionalForm], TraditionalForm]},
"Legended",
DisplayFunction->(GridBox[{{
TagBox[
ItemBox[
PaneBox[
TagBox[#, "SkipImageSizeLevel"], Alignment -> {Center, Baseline},
BaselinePosition -> Baseline], DefaultBaseStyle -> "Labeled"],
"SkipImageSizeLevel"],
ItemBox[#2, DefaultBaseStyle -> "LabeledLabel"]}},
GridBoxAlignment -> {"Columns" -> {{Center}}, "Rows" -> {{Center}}},
AutoDelete -> False, GridBoxItemSize -> Automatic,
BaselinePosition -> {1, 1}]& ),
Editable->True,
InterpretationFunction->(RowBox[{"Legended", "[",
RowBox[{#, ",",
RowBox[{"Placed", "[",
RowBox[{#2, ",", "After"}], "]"}]}], "]"}]& )]], "Output",
CellChangeTimes->{
3.818930960409805*^9, {3.818932606236885*^9, 3.8189326132449985`*^9},
3.818966155507261*^9},
CellLabel->"Out[9]=",ExpressionUUID->"071b38d2-638d-43df-875f-21f27124e888"]
}, Open ]],
Cell[CellGroupData[{
Cell[BoxData[{
RowBox[{
RowBox[{
RowBox[{"t1", "=", "70"}], ";"}],
RowBox[{"(*",
RowBox[{"Age", " ", "at", " ", "sequencing"}],
"*)"}]}], "\[IndentingNewLine]",
RowBox[{
RowBox[{
RowBox[{"R", "=", "2"}], ";"}],
RowBox[{"(*",
RowBox[{
RowBox[{"HSC", " ", "proliferation", " ", "fold"}], "-", "increase"}],
"*)"}]}], "\[IndentingNewLine]",
RowBox[{
RowBox[{"Clear", "[",
RowBox[{"b", ",", "s"}], "]"}], "\[IndentingNewLine]",
"\[IndentingNewLine]",
RowBox[{"(*",
RowBox[{"Sensitivity", " ", "analysis"}], "*)"}]}], "\[IndentingNewLine]",
RowBox[{
RowBox[{"Mx", "=", "13"}], ";",
RowBox[{"My", "=", "11"}], ";",
RowBox[{"(*",
RowBox[{"Grid", " ", "size"}], "*)"}], "\[IndentingNewLine]",
RowBox[{"f0", "=",
RowBox[{"2", "*", ".0005424"}]}], ";", " ",
RowBox[{"(*", "Initialization", "*)"}], "\[IndentingNewLine]",
RowBox[{"f1", "=",
RowBox[{"1", "/",
RowBox[{"(",
RowBox[{"1", "+",
RowBox[{
RowBox[{"(",
RowBox[{
RowBox[{"1", "/", "f0"}], "-", "1"}], ")"}],
RowBox[{"Exp", "[",
RowBox[{
RowBox[{"-", "b"}], " ", "s",
RowBox[{"(",
RowBox[{"ts", "-", "t0"}], ")"}]}], "]"}]}]}], ")"}]}]}],
";"}], "\[IndentingNewLine]",
RowBox[{
RowBox[{"f2", "=",
RowBox[{"1", "/",
RowBox[{"(",
RowBox[{"1", "+",
RowBox[{
RowBox[{"(",
RowBox[{
RowBox[{"1", "/", "f1"}], "-", "1"}], ")"}],
RowBox[{"Exp", "[",
RowBox[{
RowBox[{"-", "b"}], " ", "s",
RowBox[{"(",
RowBox[{"t1", "-", "ts"}], ")"}]}], "]"}]}]}], ")"}]}]}],
";"}], "\[IndentingNewLine]",
RowBox[{
RowBox[{"f2R", "=",
RowBox[{"1", "/",
RowBox[{"(",
RowBox[{"1", "+",
RowBox[{
RowBox[{"(",
RowBox[{
RowBox[{"1", "/", "f1"}], "-", "1"}], ")"}],
RowBox[{"Exp", "[",
RowBox[{
RowBox[{"-", "R"}], " ", "b", " ", "s",
RowBox[{"(",
RowBox[{"t1", "-", "ts"}], ")"}]}], "]"}]}]}], ")"}]}]}],
";"}], "\[IndentingNewLine]",
RowBox[{
RowBox[{"p2", "=",
RowBox[{"1", "-",
RowBox[{"CDF", "[",
RowBox[{
RowBox[{"BetaDistribution", "[",
RowBox[{
RowBox[{"f2",
RowBox[{"(",
RowBox[{
RowBox[{"f2",
RowBox[{
RowBox[{"(",
RowBox[{"1", "-", "f2"}], ")"}], "/",
RowBox[{"Sqrt", "[",
RowBox[{"f2", "/",
RowBox[{"(",
RowBox[{"s", " ", "n"}], ")"}]}], "]"}]}]}], "-", "1"}],
")"}]}], ",",
RowBox[{
RowBox[{"(",
RowBox[{"1", "-", "f2"}], ")"}],
RowBox[{"(",
RowBox[{
RowBox[{"f2",
RowBox[{
RowBox[{"(",
RowBox[{"1", "-", "f2"}], ")"}], "/",
RowBox[{"Sqrt", "[",
RowBox[{"f2", "/",
RowBox[{"(",
RowBox[{"s", " ", "n"}], ")"}]}], "]"}]}]}], "-", "1"}],
")"}]}]}], "]"}], ",", "F"}], "]"}]}]}],
";"}], "\[IndentingNewLine]",
RowBox[{
RowBox[{
RowBox[{"p2R", "=",
RowBox[{"1", "-",
RowBox[{"CDF", "[",
RowBox[{
RowBox[{"BetaDistribution", "[",
RowBox[{
RowBox[{"f2R",
RowBox[{"(",
RowBox[{
RowBox[{"f2R",
RowBox[{
RowBox[{"(",
RowBox[{"1", "-", "f2R"}], ")"}], "/",
RowBox[{"Sqrt", "[",
RowBox[{"f2R", "/",
RowBox[{"(",
RowBox[{"s", " ", "n"}], ")"}]}], "]"}]}]}], "-", "1"}],
")"}]}], ",",
RowBox[{
RowBox[{"(",
RowBox[{"1", "-", "f2R"}], ")"}],
RowBox[{"(",
RowBox[{
RowBox[{"f2R",
RowBox[{
RowBox[{"(",
RowBox[{"1", "-", "f2R"}], ")"}], "/",
RowBox[{"Sqrt", "[",