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ISCMF: Integrated Similarity-Constrained Matrix Factorization for Drug-Drug Interaction Prediction

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ISCMF: Integrated Similarity-Constrained Matrix Factorization for Drug-Drug Interaction Prediction

In this study, we use Integrated Similarity-Constrained Matrix Factorization (ISCMF) to predict DDIs. Eight similarities based on the drug substructure, targets, side effects, off-label side effects, pathways, transporters, enzymes, and indication data as well as Gaussian interaction profile for the drug pairs are calculated. Subsequently, a non-linear similarity fusion method is used to integrate multiple similarities and make them more informative. Finally, we use ISCMF which projects the drugs in the interaction space into a low-rank space constrained to obtain new insight about DDIs.

Link of paper: https://link.springer.com/article/10.1007%2Fs13721-019-0215-3

ISCMF schema

Dependency:

  • python version 3.5.3
  • scikit-learn

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Contact

Please do not hesitate to contact me if you have any question:

Email: n.rohani@mail.sbu.ac.ir

Please cite the paper if you find this study helpful.