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TrueConsense is a consensus caller for viral-targets that create biologically correct consensus sequences. TrueConsense keeps track of open reading frames, compensates for common sequencing or alignment artefacts, and is able to generate consensus sequences on multiple coverage-thresholds at the same time

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RIVM-bioinformatics/TrueConsense

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TrueConsense

TrueConsense is a nucleotide consensus caller capable of creating a biologically valid consensus-sequence in reference-based virus sequencing experiments.

TrueConsense is, in contrast to more common consensus-sequence methodology, not using VCF files. Instead, a consensus-sequence is made directly from a BAM-file in order to get a proper view of positional context.

TrueConsense compensates for common sequencing and/or alignment artefacts and keeps track of open reading frames in order to create a biologically valid viral consensus-sequence.

TrueConsense is available under the AGPLv3 licence

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TrueConsense is a consensus caller for viral-targets that create biologically correct consensus sequences. TrueConsense keeps track of open reading frames, compensates for common sequencing or alignment artefacts, and is able to generate consensus sequences on multiple coverage-thresholds at the same time

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