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luzgaral committed Mar 26, 2018
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# DoRothEA (Discriminant Regulon Expression Analysis)


DoRothEA (Discriminant Regulon Expression Analysis) is a framework to estimate single sample TF activities from gene expression data and consensus TF-target DNA binding networks. The approach asseumes that the activity of a TF can be estimated from the mRNA levels of its direct target genes. Please see [Garcia-Alonso et al 2018](http://cancerres.aacrjournals.org/content/early/2017/12/09/0008-5472.CAN-17-1679) for more datils.
DoRothEA (Discriminant Regulon Expression Analysis) is a framework to estimate single sample TF activities from gene expression data and consensus TF-target DNA binding networks. The approach assumes that the activity of a TF can be estimated from the mRNA levels of its direct target genes. Please see [Garcia-Alonso et al 2018](http://cancerres.aacrjournals.org/content/early/2017/12/09/0008-5472.CAN-17-1679) for more datils.


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