CRISPResso2 Compare interpretation

[JAVI5G]

Hi everyone, I have a questioon I hope you could help me.
I have anlaysed with CRIPSResso2 compare data from amplicon NGS. The idea is to observe if there is any off target event in a sample CRISPR-treated vs control untreated.
In the report I get, how can I know if the differences between the untreated vs the treated sample for a determinate off target are statistically significative? In the figures I got in the report, there is one calle "all modification_quentification". In the upper part of the image represents the % of difference (I asume between control vs treated?). if the peak is +, the modiffication are from the control, and if it is negative corresponds to the treated sample? In bottom part of the image, represents the p-value (-log10p-value). It is represented also the Bonferroni cut off. So, if the peak is above the Bonferroni cut off, means that the differences between the control and the treated sample are statisticlly significative (so there is an off-target??). Or the graphic shows the diference of any of the sample between the reference sequence that we introduce.
In the data report it also appear the p_values for each position change, but I don't know if they corresponds to the comparative between the two groups, or refers the differences to the reference sequence.
I would be very greatful If you could help me.
Thank you very much.

All_modifications_quantification.txt