We investigated the differential effects of APOE alleles on the microglia and astrocyte transcriptome in the absence and presence of neuritic plaques (NPs) using bulk brain RNA-seq data from two large brain banks and performed follow-on experiments in APOE knock-in mice.
Install R to run our code.
To read our documented code, please visit mindds.github.io/apoe-glia or see below.
Our full codebase is available for download on GitHub.