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In Alzheimer’s disease, abnormal levels of the Aβ protein aggregate together to form Aβ plaques. The response to plaques by microglial cells is characterised by changes in gene expression and an increase in cell density surrounding plaques. This set of semi-automated macros calculates both microglial density and changes in protein expression int…

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RidwaanJoghee/Amyloid-Beta-Concentric-Circle-Spatial-Analysis

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Copyright (c) 2022, Ridwaan M. Joghee, MRes Biosciences (Neuroscience), University College London, Department of Neuroscience, Physiology, and Pharmacology, Professor Edwards' Lab

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In Alzheimer’s disease, abnormal levels of the Aβ protein aggregate together to form Aβ plaques. The response to plaques by microglial cells is characterised by changes in gene expression and an increase in cell density surrounding plaques. This set of semi-automated macros calculates both microglial density and changes in protein expression int…

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