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Equivalent excitability achieved via different Nav subtypes (Xie et al., 2024)

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Files:

  1. smallDRG_DIV0.m for DIV0 simulations
  2. smallDRG_DIV7.m for DIV4-7 simulations

To get started,

  1. Type smallDRG_DIV0(17,1500,500,1000) in the command line to reproduce DIV0 baseline.
  2. Type smallDRG_DIV7(12,1500,500,1000) in the command line to reproduce DIV4-7 baseline.

To reproduce figures:

  1. Uncomment line 42 in smallDRG_DIV0.m to simulate Nav1.8 blockade in Fig.2D.
  2. Uncomment line 43 and 44, respectively, in smallDRG_DIV7.m to simulate Nav1.7 or 1.3 blockade in Fig.3D.
  3. Uncomment line 45 in smallDRG_DIV0.m for virtual Nav1.7 or line 47 in smallDRG_DIV7.m for virtual Nav1.8 in Fig.4A.
  4. Uncomment line 51 or 52 in smallDRG_DIV7.m to reproduce Fig.S4.

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Equivalent excitability achieved via different Nav subtypes (Xie et al., 2024)

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