hIPSC-CM-CAV3

Myokit code for simulations with the WT and CAV3 KO versions of the Kernik hIPSC cardiomyocyte model

Functional Stabilization of the Lactate-Proton Shuttle McT1 Requires Isoform-specific Caveolin Interactions in Cardiomyocyctes

This GitHub page contains the source codes in Myokit file format (.mmt) for:

1. INaL optimization (based on voltage clamp experiments data)
2. 0-dimensional simulation of EAD in Kernik hiPSC-CM model
3. 2-dimensional simulation of hiPSC model with heterogenous repolarization region
4. Example video of 2-dimensional simulation of hiPSC model with heterogenous repolarization region, resulting in figure-8 of reentry

The details of parameter modifications to reproduce WT and CAV3 KO in both EAD-resistant and prone cell can be seen in Supplementary Material (Online Table XVIII)

Citation: N/A

Link to the fulltext: N/A

For queries, do not hesitate to contact us: Jordi Heijman, PhD Dept. of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University PO Box 616, 6200 MD, Maastricht, The Netherlands E-Mail: jordi.heijman@maastrichtuniversity.nl