Beta-adrenergic receptor stimulation modulates the cellular proarrhythmic effects of chloroquine and azithromycin
Authors: Henry Sutanto and Jordi Heijman
This GitHub page contains the source codes in Myokit file format (.mmt) for:
- Base model of Heijman 2011 Canine Ventricular Epicardium and O'Hara-Rudy 2011 Human Ventricular Epicardium (with BARS +/-)
- 0-dimensional simulation of CQ and AZM (rate dependence)
- Population-based study divided into 2 parts:
- Part 1 contains the code to generate random variability of ionic currents
- Part 2 to run the data obtained in Part 1 for specific conditions (+/- ISO, +/- CQ and AZM)
Citation: Sutanto H and Heijman J (2020) Beta-Adrenergic Receptor Stimulation Modulates the Cellular Proarrhythmic Effects of Chloroquine and Azithromycin. Front. Physiol. 11:587709. doi: 10.3389/fphys.2020.587709
Link to the fulltext: https://www.frontiersin.org/articles/10.3389/fphys.2020.587709
For queries, do not hesitate to contact us: Jordi Heijman, PhD Dept. of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University PO Box 616, 6200 MD, Maastricht, The Netherlands E-Mail: jordi.heijman@maastrichtuniversity.nl