v1.6.0 - 2019-06-25
This is a significant engineering update from the v1.5.1 release, in which the SV candidate generation step has been changed to a single multi-threaded process to improve task scheduling. This slightly improves average runtime and reduces runtime variability. With this update, support for job distribution over SGE is dropped.
Added
- Add configuration option to turn off the evidence signal filter during candidate generation (DRAGEN-1873)
- This enables very high sensitivity during high depth tumor-only calling
Changed
- Change the SV candidate discovery and genotyping phase from a multi-process to a multi-thread design for better CPU utilization (MANTA-1521)
- As a result, runtime is faster and less variable than before.
- Runtime improvements vary by workload and server configuration, for typical WGS workloads on a modern server an improvement of ~5-10% may be expected, but improvements of up to 50% have been observed for cases where work previously was poorly distributed across processes.
- SGE support is removed with this change.
- Update htslib/samtools to 1.9 (MANTA-1483)
manta-1.6.0.centos6_x86_64.tar.bz2 is a binary distribution for 64-bit linux. This is built on CentOS 6 with all dependencies except glibc statically linked. It is expected to run without modification on most linux distributions.
The manta-1.6.0.release_src.tar.bz2 download is the full source code release. The “Source code” downloads are generated by GitHub and are incomplete as they are missing version numbers and build system changes to improve portability.