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Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes

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Hon-lab/Breast_cancer_perturbation

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Overview

This repository contains the jupyter lab notebooks of analysis and plotting after performing pySpade analysis of breast cancer associated enhancers perturbations.

Link to pySpade

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Requirement

  • Python (3.7 +)
  • Numpy (1.16 +)
  • Pandas (0.25 +)
  • Scipy (1.1 +)
  • Matplotlib (3.3 +)
  • pyCircos (0.3.0 +)

Fastq files

  • GSE223812: Bulk ATAC-seq of breast cancer cell lines.
  • GSE224986: Single cell libraries.
  • GSE228332: Bulk RNA-seq validation experiments.

Contributors

  • First Author: Yihan Wang Yihan.Wang@UTSouthwestern.edu
  • Corresponding Author: Gary Hon Gary.Hon@UTSouthwestern.edu

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Enhancer regulatory networks globally connect non-coding breast cancer loci to cancer genes

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