-
Notifications
You must be signed in to change notification settings - Fork 0
/
step3_predict_nodules.py
363 lines (308 loc) · 17.8 KB
/
step3_predict_nodules.py
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
import settings
import helpers
import sys
import os
import glob
import random
import pandas
import ntpath
import cv2
import numpy
from typing import List, Tuple
from keras.optimizers import Adam, SGD
from keras.layers import Input, Convolution2D, MaxPooling2D, UpSampling2D, merge, Convolution3D, MaxPooling3D, UpSampling3D, LeakyReLU, BatchNormalization, Flatten, Dense, Dropout, ZeroPadding3D, AveragePooling3D, Activation
from keras.models import Model, load_model, model_from_json
from keras.metrics import binary_accuracy, binary_crossentropy, mean_squared_error, mean_absolute_error
from keras import backend as K
from keras.callbacks import ModelCheckpoint, Callback, LearningRateScheduler
from scipy.ndimage.interpolation import map_coordinates
from scipy.ndimage.filters import gaussian_filter
import math
# limit memory usage..
import tensorflow as tf
from keras.backend.tensorflow_backend import set_session
import step2_train_nodule_detector
config = tf.ConfigProto()
config.gpu_options.per_process_gpu_memory_fraction = 0.5
set_session(tf.Session(config=config))
# zonder aug, 10:1 99 train, 97 test, 0.27 cross entropy, before commit 573
# 3 pools istead of 4 gives (bigger end layer) gives much worse validation accuray + logloss .. strange ?
# 32 x 32 x 32 lijkt het beter te doen dan 48 x 48 x 48..
K.set_image_dim_ordering("tf")
CUBE_SIZE = step2_train_nodule_detector.CUBE_SIZE
MEAN_PIXEL_VALUE = settings.MEAN_PIXEL_VALUE_NODULE
NEGS_PER_POS = 20
P_TH = 0.6
PREDICT_STEP = 12
USE_DROPOUT = False
def prepare_image_for_net3D(img):
img = img.astype(numpy.float32)
img -= MEAN_PIXEL_VALUE
img /= 255.
img = img.reshape(1, img.shape[0], img.shape[1], img.shape[2], 1)
return img
def filter_patient_nodules_predictions(df_nodule_predictions: pandas.DataFrame, patient_id, view_size, luna16=False):
src_dir = settings.LUNA_16_TRAIN_DIR2D2 if luna16 else settings.NDSB3_EXTRACTED_IMAGE_DIR
patient_mask = helpers.load_patient_images(patient_id, src_dir, "*_m.png")
delete_indices = []
for index, row in df_nodule_predictions.iterrows():
z_perc = row["coord_z"]
y_perc = row["coord_y"]
center_x = int(round(row["coord_x"] * patient_mask.shape[2]))
center_y = int(round(y_perc * patient_mask.shape[1]))
center_z = int(round(z_perc * patient_mask.shape[0]))
mal_score = row["diameter_mm"]
start_y = center_y - view_size / 2
start_x = center_x - view_size / 2
nodule_in_mask = False
for z_index in [-1, 0, 1]:
img = patient_mask[z_index + center_z]
start_x = int(start_x)
start_y = int(start_y)
view_size = int(view_size)
img_roi = img[start_y:start_y+view_size, start_x:start_x + view_size]
if img_roi.sum() > 255: # more than 1 pixel of mask.
nodule_in_mask = True
if not nodule_in_mask:
print("Nodule not in mask: ", (center_x, center_y, center_z))
if mal_score > 0:
mal_score *= -1
df_nodule_predictions.loc[index, "diameter_mm"] = mal_score
else:
if center_z < 30:
print("Z < 30: ", patient_id, " center z:", center_z, " y_perc: ", y_perc)
if mal_score > 0:
mal_score *= -1
df_nodule_predictions.loc[index, "diameter_mm"] = mal_score
if (z_perc > 0.75 or z_perc < 0.25) and y_perc > 0.85:
print("SUSPICIOUS FALSEPOSITIVE: ", patient_id, " center z:", center_z, " y_perc: ", y_perc)
if center_z < 50 and y_perc < 0.30:
print("SUSPICIOUS FALSEPOSITIVE OUT OF RANGE: ", patient_id, " center z:", center_z, " y_perc: ", y_perc)
df_nodule_predictions.drop(df_nodule_predictions.index[delete_indices], inplace=True)
return df_nodule_predictions
def filter_nodule_predictions(only_patient_id=None):
src_dir = settings.NDSB3_NODULE_DETECTION_DIR
for csv_index, csv_path in enumerate(glob.glob(src_dir + "*.csv")):
file_name = ntpath.basename(csv_path)
patient_id = file_name.replace(".csv", "")
print(csv_index, ": ", patient_id)
if only_patient_id is not None and patient_id != only_patient_id:
continue
df_nodule_predictions = pandas.read_csv(csv_path)
filter_patient_nodules_predictions(df_nodule_predictions, patient_id, CUBE_SIZE)
df_nodule_predictions.to_csv(csv_path, index=False)
def make_negative_train_data_based_on_predicted_luna_nodules():
src_dir = settings.LUNA_NODULE_DETECTION_DIR
pos_labels_dir = settings.LUNA_NODULE_LABELS_DIR
keep_dist = CUBE_SIZE + CUBE_SIZE / 2
total_false_pos = 0
for csv_index, csv_path in enumerate(glob.glob(src_dir + "*.csv")):
file_name = ntpath.basename(csv_path)
patient_id = file_name.replace(".csv", "")
# if not "273525289046256012743471155680" in patient_id:
# continue
df_nodule_predictions = pandas.read_csv(csv_path)
pos_annos_manual = None
manual_path = settings.MANUAL_ANNOTATIONS_LABELS_DIR + patient_id + ".csv"
if os.path.exists(manual_path):
pos_annos_manual = pandas.read_csv(manual_path)
filter_patient_nodules_predictions(df_nodule_predictions, patient_id, CUBE_SIZE, luna16=True)
pos_labels = pandas.read_csv(pos_labels_dir + patient_id + "_annos_pos_lidc.csv")
print(csv_index, ": ", patient_id, ", pos", len(pos_labels))
patient_imgs = helpers.load_patient_images(patient_id, settings.LUNA_16_TRAIN_DIR2D2, "*_m.png")
for nod_pred_index, nod_pred_row in df_nodule_predictions.iterrows():
if nod_pred_row["diameter_mm"] < 0:
continue
nx, ny, nz = helpers.percentage_to_pixels(nod_pred_row["coord_x"], nod_pred_row["coord_y"], nod_pred_row["coord_z"], patient_imgs)
diam_mm = nod_pred_row["diameter_mm"]
for label_index, label_row in pos_labels.iterrows():
px, py, pz = helpers.percentage_to_pixels(label_row["coord_x"], label_row["coord_y"], label_row["coord_z"], patient_imgs)
dist = math.sqrt(math.pow(nx - px, 2) + math.pow(ny - py, 2) + math.pow(nz- pz, 2))
if dist < keep_dist:
if diam_mm >= 0:
diam_mm *= -1
df_nodule_predictions.loc[nod_pred_index, "diameter_mm"] = diam_mm
break
if pos_annos_manual is not None:
for index, label_row in pos_annos_manual.iterrows():
px, py, pz = helpers.percentage_to_pixels(label_row["x"], label_row["y"], label_row["z"], patient_imgs)
diameter = label_row["d"] * patient_imgs[0].shape[1]
# print((pos_coord_x, pos_coord_y, pos_coord_z))
# print(center_float_rescaled)
dist = math.sqrt(math.pow(px - nx, 2) + math.pow(py - ny, 2) + math.pow(pz - nz, 2))
if dist < (diameter + 72): # make sure we have a big margin
if diam_mm >= 0:
diam_mm *= -1
df_nodule_predictions.loc[nod_pred_index, "diameter_mm"] = diam_mm
print("#Too close", (nx, ny, nz))
break
df_nodule_predictions.to_csv(csv_path, index=False)
df_nodule_predictions = df_nodule_predictions[df_nodule_predictions["diameter_mm"] >= 0]
df_nodule_predictions.to_csv(pos_labels_dir + patient_id + "_candidates_falsepos.csv", index=False)
total_false_pos += len(df_nodule_predictions)
print("Total false pos:", total_false_pos)
def predict_cubes(model_path, continue_job, only_patient_id=None, luna16=False, magnification=1, flip=False, train_data=True, holdout_no=-1, ext_name="", fold_count=2):
if luna16:
dst_dir = settings.LUNA_NODULE_DETECTION_DIR
else:
dst_dir = settings.NDSB3_NODULE_DETECTION_DIR
if not os.path.exists(dst_dir):
os.makedirs(dst_dir)
holdout_ext = ""
# if holdout_no is not None:
# holdout_ext = "_h" + str(holdout_no) if holdout_no >= 0 else ""
flip_ext = ""
if flip:
flip_ext = "_flip"
dst_dir += "predictions" + str(int(magnification * 10)) + holdout_ext + flip_ext + "_" + ext_name + "/"
if not os.path.exists(dst_dir):
os.makedirs(dst_dir)
sw = helpers.Stopwatch.start_new()
model = step2_train_nodule_detector.get_net(input_shape=(CUBE_SIZE, CUBE_SIZE, CUBE_SIZE, 1), load_weight_path=model_path)
if not luna16:
if train_data:
labels_df = pandas.read_csv("resources/stage1_labels.csv")
labels_df.set_index(["id"], inplace=True)
else:
labels_df = pandas.read_csv("resources/stage2_sample_submission.csv")
labels_df.set_index(["id"], inplace=True)
patient_ids = []
for file_name in os.listdir(settings.NDSB3_EXTRACTED_IMAGE_DIR):
if not os.path.isdir(settings.NDSB3_EXTRACTED_IMAGE_DIR + file_name):
continue
patient_ids.append(file_name)
all_predictions_csv = []
for patient_index, patient_id in enumerate(reversed(patient_ids)):
if not luna16:
if patient_id not in labels_df.index:
continue
if "metadata" in patient_id:
continue
if only_patient_id is not None and only_patient_id != patient_id:
continue
if holdout_no is not None and train_data:
patient_fold = helpers.get_patient_fold(patient_id)
patient_fold %= fold_count
if patient_fold != holdout_no:
continue
print(patient_index, ": ", patient_id)
csv_target_path = dst_dir + patient_id + ".csv"
if continue_job and only_patient_id is None:
if os.path.exists(csv_target_path):
continue
patient_img = helpers.load_patient_images(patient_id, settings.NDSB3_EXTRACTED_IMAGE_DIR, "*_i.png", [])
if magnification != 1:
patient_img = helpers.rescale_patient_images(patient_img, (1, 1, 1), magnification)
patient_mask = helpers.load_patient_images(patient_id, settings.NDSB3_EXTRACTED_IMAGE_DIR, "*_m.png", [])
if magnification != 1:
patient_mask = helpers.rescale_patient_images(patient_mask, (1, 1, 1), magnification, is_mask_image=True)
# patient_img = patient_img[:, ::-1, :]
# patient_mask = patient_mask[:, ::-1, :]
step = PREDICT_STEP
CROP_SIZE = CUBE_SIZE
# CROP_SIZE = 48
predict_volume_shape_list = [0, 0, 0]
for dim in range(3):
dim_indent = 0
while dim_indent + CROP_SIZE < patient_img.shape[dim]:
predict_volume_shape_list[dim] += 1
dim_indent += step
predict_volume_shape = (predict_volume_shape_list[0], predict_volume_shape_list[1], predict_volume_shape_list[2])
predict_volume = numpy.zeros(shape=predict_volume_shape, dtype=float)
print("Predict volume shape: ", predict_volume.shape)
done_count = 0
skipped_count = 0
batch_size = 128
batch_list = []
batch_list_coords = []
patient_predictions_csv = []
cube_img = None
annotation_index = 0
for z in range(0, predict_volume_shape[0]):
for y in range(0, predict_volume_shape[1]):
for x in range(0, predict_volume_shape[2]):
#if cube_img is None:
cube_img = patient_img[z * step:z * step+CROP_SIZE, y * step:y * step + CROP_SIZE, x * step:x * step+CROP_SIZE]
cube_mask = patient_mask[z * step:z * step+CROP_SIZE, y * step:y * step + CROP_SIZE, x * step:x * step+CROP_SIZE]
if cube_mask.sum() < 2000:
skipped_count += 1
else:
if flip:
cube_img = cube_img[:, :, ::-1]
if CROP_SIZE != CUBE_SIZE:
cube_img = helpers.rescale_patient_images2(cube_img, (CUBE_SIZE, CUBE_SIZE, CUBE_SIZE))
# helpers.save_cube_img("c:/tmp/cube.png", cube_img, 8, 4)
# cube_mask = helpers.rescale_patient_images2(cube_mask, (CUBE_SIZE, CUBE_SIZE, CUBE_SIZE))
img_prep = prepare_image_for_net3D(cube_img)
batch_list.append(img_prep)
batch_list_coords.append((z, y, x))
if len(batch_list) % batch_size == 0:
batch_data = numpy.vstack(batch_list)
p = model.predict(batch_data, batch_size=batch_size)
for i in range(len(p[0])):
p_z = batch_list_coords[i][0]
p_y = batch_list_coords[i][1]
p_x = batch_list_coords[i][2]
nodule_chance = p[0][i][0]
predict_volume[p_z, p_y, p_x] = nodule_chance
if nodule_chance > P_TH:
p_z = p_z * step + CROP_SIZE / 2
p_y = p_y * step + CROP_SIZE / 2
p_x = p_x * step + CROP_SIZE / 2
p_z_perc = round(p_z / patient_img.shape[0], 4)
p_y_perc = round(p_y / patient_img.shape[1], 4)
p_x_perc = round(p_x / patient_img.shape[2], 4)
diameter_mm = round(p[1][i][0], 4)
# diameter_perc = round(2 * step / patient_img.shape[2], 4)
diameter_perc = round(2 * step / patient_img.shape[2], 4)
diameter_perc = round(diameter_mm / patient_img.shape[2], 4)
nodule_chance = round(nodule_chance, 4)
patient_predictions_csv_line = [annotation_index, p_x_perc, p_y_perc, p_z_perc, diameter_perc, nodule_chance, diameter_mm]
patient_predictions_csv.append(patient_predictions_csv_line)
all_predictions_csv.append([patient_id] + patient_predictions_csv_line)
annotation_index += 1
batch_list = []
batch_list_coords = []
done_count += 1
if done_count % 10000 == 0:
print("Done: ", done_count, " skipped:", skipped_count)
df = pandas.DataFrame(patient_predictions_csv, columns=["anno_index", "coord_x", "coord_y", "coord_z", "diameter", "nodule_chance", "diameter_mm"])
filter_patient_nodules_predictions(df, patient_id, CROP_SIZE * magnification)
df.to_csv(csv_target_path, index=False)
# cols = ["anno_index", "nodule_chance", "diamete_mm"] + ["f" + str(i) for i in range(64)]
# df_features = pandas.DataFrame(patient_features_csv, columns=cols)
# for index, row in df.iterrows():
# if row["diameter_mm"] < 0:
# print("Dropping")
# anno_index = row["anno_index"]
# df_features.drop(df_features[df_features["anno_index"] == anno_index].index, inplace=True)
#
# df_features.to_csv(csv_target_path_features, index=False)
# df = pandas.DataFrame(all_predictions_csv, columns=["patient_id", "anno_index", "coord_x", "coord_y", "coord_z", "diameter", "nodule_chance", "diameter_mm"])
# df.to_csv("c:/tmp/tmp2.csv", index=False)
print(predict_volume.mean())
print("Done in : ", sw.get_elapsed_seconds(), " seconds")
if __name__ == "__main__":
CONTINUE_JOB = True
only_patient_id = None # "ebd601d40a18634b100c92e7db39f585"
if not CONTINUE_JOB or only_patient_id is not None:
for file_path in glob.glob("c:/tmp/*.*"):
if not os.path.isdir(file_path):
remove_file = True
if only_patient_id is not None:
if only_patient_id not in file_path:
remove_file = False
remove_file = False
if remove_file:
os.remove(file_path)
if True:
for magnification in [1, 1.5, 2]: #
predict_cubes("models/model_luna16_full__fs_best.hd5", CONTINUE_JOB, only_patient_id=only_patient_id, magnification=magnification, flip=False, train_data=True, holdout_no=None, ext_name="luna16_fs")
predict_cubes("models/model_luna16_full__fs_best.hd5", CONTINUE_JOB, only_patient_id=only_patient_id, magnification=magnification, flip=False, train_data=False, holdout_no=None, ext_name="luna16_fs")
if True:
for version in [2, 1]:
for holdout in [0, 1]:
for magnification in [1, 1.5, 2]: #
predict_cubes("models/model_luna_posnegndsb_v" + str(version) + "__fs_h" + str(holdout) + "_end.hd5", CONTINUE_JOB, only_patient_id=only_patient_id, magnification=magnification, flip=False, train_data=True, holdout_no=holdout, ext_name="luna_posnegndsb_v" + str(version), fold_count=2)
if holdout == 0:
predict_cubes("models/model_luna_posnegndsb_v" + str(version) + "__fs_h" + str(holdout) + "_end.hd5", CONTINUE_JOB, only_patient_id=only_patient_id, magnification=magnification, flip=False, train_data=False, holdout_no=holdout, ext_name="luna_posnegndsb_v" + str(version), fold_count=2)