The compartmental model for aluminium kinetics in human body of Nolte et al, as reparameterized by Weisser et al, implemented under mrgsolve and R.
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Updated
Oct 20, 2017 - C++
The compartmental model for aluminium kinetics in human body of Nolte et al, as reparameterized by Weisser et al, implemented under mrgsolve and R.
Prediction of partition coefficient
Simplest mathematical model for drug concentration in blood plasma vs. time
Customisable pharmacokinetic model accessible via bash CLI allowing for variable dose calculations as well as intravenous and subcutaneous administration calculations
Raw R code used in manuscript: Hughes JH, Phelps MA, Upton RN, et al. Population pharmacokinetics of lenalidomide in patients with B-cell malignancies. Br J Clin Pharmacol. 2019;85(5):924-934.
Calcium Caffeine Model Simulations. Post-graduate work for Dr. Stephanie Reuter-Lange at University of South Australia.
Python project that simulates a Target Controlled Infusion pump for anesthesia delivery
Raw R code used in manuscript: Hughes JH, Upton RN, Foster DJR. Comparison of non-compartmental and mixed effect modelling methods for establishing bioequivalence for the case of two compartment kinetics and censored concentrations. J Pharmacokinet Pharmacodyn. 2017:1-12.
Raw R code for manuscript: Hughes JH, Upton RN, Reuter SE, Rozewski DM, Phelps MA, Foster DJR. Development of a physiologically-based pharmacokinetic model for intravenous lenalidomide in mice.
가이드라인: 임상시험의 통계 원칙 - 식품의약품안전처 식품의약품안전평가원 의약품심사부 의약품심사조정과 https://pipetcpt.github.io/book-stat
Dosing application for manuscript: Harris, B.D.W., Phan, V., Perera, V. et al. Inability of Current Dosing to Achieve Carboplatin Therapeutic Targets in People with Advanced Non-Small Cell Lung Cancer: Impact of Systemic Inflammation on Carboplatin Exposure and Clinical Outcomes. Clin Pharmacokinet (2020). https://doi.org/10.1007/s40262-020-00870-6
Simulate the absorption and elimination of drugs in real time using pharmacokinetic formulas.
😩 OBSOLETE! R package: Noncompartmental Analysis of Pharmacokinetic Data for CDISC Standardized Parameters
R code for manuscript: Hughes JH, Upton RN, Reuter SE, Phelps MA, Foster DJR. Optimising time samples for determining AUC of pharmacokinetic data using non-compartmental analysis. - Web App can be found at:
Raw R code used in draft manuscript: Hughes JH, Roussin-Bouchard U, Wang Y, Boddy AV, Reuter SE. Reduction of Nivolumab Dosing using Adaptive-Dosage Strategies
Empirical MAP Bayes examples and applications. Post-graduate work for Dr. Stephanie Reuter-Lange at University of South Australia.
Web application, raw code and digitised data for published manuscript: Hughes, J.H., Sweeney, K., Ahadieh, S. and Ouellet, D. (2020), Predictions of Systemic, Intracellular, and Lung Concentrations of Azithromycin with Different Dosing Regimens used in COVID‐19 Clinical Trials. CPT Pharmacometrics Syst. Pharmacol. Application can be found at:
Project archive for the Systems Pharmacology & Personalized Medicine course at JHU during Spring 2021 Semester
💊 Conceptual custom GPT that simulates the pharmacokinetics and pharmacodynamics of drugs.
A modular inverse QSAR pipeline
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