How to balance mcool files.

[1944498970]

Hi，jimin
How do you perform balance processing on mcool files? When I use hic-bench's track to generate an mcool file using juicertools, I encounter an error because the -k parameter in addnorm is not available in the new version. Then I use Cooler to balance the mcool file, but the generated values are extremely small, mostly ranging from 0 to 0.01. However, when I downloaded your data and viewed it, I found that the values were distributed from 0 to 40.
Thanks!

[tanjimin]

Hi @1944498970 the normalization might be different. If you want to re-train on already normalized data you can probably remove the Hi-C matrix log1p transformation in dataloader.