diff --git a/snakemake/dag.py b/snakemake/dag.py
index 12f99175d..633e1f4a6 100755
--- a/snakemake/dag.py
+++ b/snakemake/dag.py
@@ -1308,6 +1308,12 @@ def handle_pipes_and_services(self):
                             "a dead lock.".format(f),
                             rule=job.rule,
                         )
+                    elif is_pipe and depending[0].is_norun:
+                        raise WorkflowError(
+                            f"Output file {f} is marked as pipe but is requested by a rule that "
+                            "does not execute anything. This is not allowed because it would lead "
+                            "to a dead lock."
+                        )
 
                     for dep in depending:
                         if dep.is_run:
diff --git a/tests/test_pipe_depend/Snakefile b/tests/test_pipe_depend/Snakefile
new file mode 100644
index 000000000..a87a9d4a6
--- /dev/null
+++ b/tests/test_pipe_depend/Snakefile
@@ -0,0 +1,11 @@
+rule all:
+    input:
+        "test.txt"
+
+
+rule a:
+    output:
+        pipe("test.txt")
+    shell:
+        "echo test > {output}"
+
diff --git a/tests/test_pipe_depend/expected-results/.gitkeep b/tests/test_pipe_depend/expected-results/.gitkeep
new file mode 100644
index 000000000..e69de29bb
diff --git a/tests/tests.py b/tests/tests.py
index f95c2109e..4783b024d 100644
--- a/tests/tests.py
+++ b/tests/tests.py
@@ -1565,3 +1565,13 @@ def test_service_jobs():
 
 def test_incomplete_params():
     run(dpath("test_incomplete_params"), dryrun=True, printshellcmds=True)
+
+
+@skip_on_windows  # no pipe support on windows
+def test_pipe_depend():
+    run(dpath("test_pipe_depend"), shouldfail=True)
+
+
+@skip_on_windows  # no pipe support on windows
+def test_pipe_depend_target_file():
+    run(dpath("test_pipe_depend"), targets=["test.txt"], shouldfail=True)