diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 2d02cc07a22..41e756a8adf 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -108,17 +108,22 @@ jobs:
     strategy:
       matrix:
         go-version: ["~1.22.0", "~1.21.3"]
-        os: [ubuntu-latest, macos-latest, windows-latest]
-        # GitHub Actions does not support arm* architectures on default
-        # runners. It is possible to accomplish this with a self-hosted runner
-        # if we want to add this in the future:
-        # https://docs.github.com/en/actions/hosting-your-own-runners/using-self-hosted-runners-in-a-workflow
-        arch: ["386", amd64]
-        exclude:
-          # Not a supported Go OS/architecture.
+        platform:
+          - os: ubuntu-latest
+            arch: "386"
+          - os: ubuntu-latest
+            arch: amd64
           - os: macos-latest
+            arch: amd64
+          - os: windows-latest
             arch: "386"
-    runs-on: ${{ matrix.os }}
+          - os: windows-latest
+            arch: amd64
+          # ARM64 compatibility tests are using actuated runners
+          # See https://github.com/open-telemetry/community/blob/main/docs/using-actuated.md
+          - os: actuated-arm64-2cpu-8gb
+            arch: arm64
+    runs-on: ${{ matrix.platform.os }}
     steps:
       - name: Checkout code
         uses: actions/checkout@v4
@@ -130,7 +135,7 @@ jobs:
           cache-dependency-path: "**/go.sum"
       - name: Run tests
         env:
-          GOARCH: ${{ matrix.arch }}
+          GOARCH: ${{ matrix.platform.arch }}
         run: make test-short
 
   test-compatibility:
diff --git a/CHANGELOG.md b/CHANGELOG.md
index 68cc02b478e..4d6d0bef9dc 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -50,6 +50,7 @@ The next release will require at least [Go 1.21].
   This module includes OpenTelemetry Go's implementation of the Logs Bridge API.
   This module is in an alpha state, it is subject to breaking changes.
   See our [versioning policy](./VERSIONING.md) for more info. (#4961)
+- ARM64 platform to the compatibility testing suite. (#4994)
 
 ### Fixed
 
diff --git a/README.md b/README.md
index aa9baa6c627..47f9a41f66d 100644
--- a/README.md
+++ b/README.md
@@ -53,6 +53,8 @@ Currently, this project supports the following environments.
 | Ubuntu  | 1.21       | amd64        |
 | Ubuntu  | 1.22       | 386          |
 | Ubuntu  | 1.21       | 386          |
+| Linux   | 1.22       | arm64        |
+| Linux   | 1.21       | arm64        |
 | MacOS   | 1.22       | amd64        |
 | MacOS   | 1.21       | amd64        |
 | Windows | 1.22       | amd64        |