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DESCRIPTION
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DESCRIPTION
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Type: Package
Package: WatershedR
Title: Prioritization of functional rare genetic variants by integrating
genomic annotations and RNA-seq
Version: 1.0.0
Authors@R: c(
person("Ben", "Strober", , "bstrober3@gmail.com", role = "aut"),
person("Nicole", "Gay", , "nicole.r.gay@gmail.com", role = c("cre","ctb"))
)
Description: Watershed is an unsupervised probabilistic framework that
integrates genomic annotations and RNA-seq outlier calls to identify
the probability a rare variant has a functional effect on a particular
RNA-seq outlier phenotype (examples of outlier phenotypes can be, but
are not limited to total expression, splicing, or ASE). Watershed
extends our previous model RIVER (which can also be run via this
package) by incoorperating information from multiple outlier
phenoytpes into one model, where predictions for functional effects in
one outlier phenotype are informed by observed outlier calls in
another phenotype.
License: MIT + file LICENSE
URL: https://github.com/nicolerg/WatershedR,
https://github.com/BennyStrobes/Watershed,
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646251/
Imports:
Rcpp (>= 1.0.9),
lbfgs,
PRROC,
RCurl
Encoding: UTF-8
RoxygenNote: 7.2.1
Roxygen: list(markdown = TRUE)
LinkingTo: Rcpp
Suggests:
knitr,
rmarkdown
VignetteBuilder: knitr