Any considerations for RNA motif discovery because of Coarse-Grained Affinity Matrix Computation?

[AidenSb]

Hi @AvantiShri,
Thanks again for the great work. I'm wondering if we should change anything in modisco workflow for RNAs? should we just set revcomp FAlSE? I'm asking this because of the concern issued in the paper in the 4.1.1 Coarse-Grained Affinity Matrix Computation section.

Thanks

[AvantiShri]

Hi Aidedn, sorry for the late reply, I've been navigating some health issues. Yes, setting revcomp to false is the only change made when applying deeplift to RNA sequences

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On Thu, 28 Jul 2022 at 00:38, Aiden M Sababi ***@***.***> wrote: Hi @AvantiShri <https://github.com/AvantiShri>, Thanks again for the great work. I'm wondering if we should change anything in modisco workflow for RNAs? should we just set revcomp FAlSE? I'm asking this because of the concern issued in the paper in the 4.1.1 Coarse-Grained Affinity Matrix Computation section. Thanks — Reply to this email directly, view it on GitHub <#105>, or unsubscribe <https://github.com/notifications/unsubscribe-auth/AARSFBRLMQUORN23EXLL3TTVWGCK7ANCNFSM542WGVYQ> . You are receiving this because you were mentioned.Message ID: ***@***.***>