diff --git a/README.md b/README.md index 0d2e632..db62b16 100755 --- a/README.md +++ b/README.md @@ -1,23 +1,38 @@ `SEQMAK` ======== -`SEQMAK` (pronounced SEC-mac) is a near clone of SEQUIN which was written by Ned Seeman ([1][first], [2][second]). The main differences are +`SEQMAK` (pronounced SEC-mac) is a program for producing DNA sequences. Much of +the inspiration for `SEQMAK` comes from SEQUIN which was written by Ned Seeman +([1][first], [2][second]). The main differences are -* much of the repetitive nature of SEQUIN has been automated, +* much of the repetitive nature of SEQUIN has been automated with some added + functionality (*e.g.* dyad symmetry checking), * exception handling has been much improved, and -* all features have been modularized, making the code much easier to read, learn, and maintain. +* all features have been modularized, making the code much easier to read, + learn, and maintain. -As is the case with SEQUIN, kinetic and thermodynamic factors are not taken into -account when designing structures with SEQMAK . Only different combinations of DNA bases are considered. If you would like to consider other factors when designing your DNA structure, you may want to use a more complex program such as [DNAdesign](http://dna.caltech.edu/DNAdesign/). +As is the case with SEQUIN, kinetic and thermodynamic factors are not taken +into account when designing structures with SEQMAK . Only different +combinations of DNA bases are considered. If you would like to consider other +factors when designing your DNA structure, you may want to use a more complex +program such as [DNAdesign](http://dna.caltech.edu/DNAdesign/). Dependencies ------------ -`SEQMAK` is written in Python 2.7. In order to run the program you must have Python installed on your computer (preferably version 2.7x but version 2.4x should also work). This software has not been tested with Python 3.0 or higher, so I cannot guarantee it will work under those environments. If you do not have Python installed on your computer, you may download the latest version at [http://www.python.org/download/](http://www.python.org/download/). -All python package dependencies can be installed using `pip`. `pip` does not come pre-installed with the python virtual machine, so you need to install it manually. +`SEQMAK` is written in Python 2.7. In order to run the program you must have +Python installed on your computer (preferably version 2.7x but version 2.4x +should also work). This software has not been tested with Python 3.0 or higher, +so I cannot guarantee it will work under those environments. If you do not have +Python installed on your computer, you may download the latest version at +[http://www.python.org/download/](http://www.python.org/download/). + +All python package dependencies can be installed using `pip`. `pip` does not +come pre-installed with the python virtual machine, so you need to install it +manually. * Install pip (if you do not have it installed)