diff --git a/google/cloud/spanner_dbapi/cursor.py b/google/cloud/spanner_dbapi/cursor.py
index bcb614cf7e..b00675dbb8 100644
--- a/google/cloud/spanner_dbapi/cursor.py
+++ b/google/cloud/spanner_dbapi/cursor.py
@@ -174,7 +174,10 @@ def execute(self, sql, args=None):
         try:
             classification = parse_utils.classify_stmt(sql)
             if classification == parse_utils.STMT_DDL:
-                self.connection._ddl_statements.append(sql)
+                for ddl in sql.split(";"):
+                    ddl = ddl.strip()
+                    if ddl:
+                        self.connection._ddl_statements.append(ddl)
                 return
 
             # For every other operation, we've got to ensure that
diff --git a/tests/unit/spanner_dbapi/test_cursor.py b/tests/unit/spanner_dbapi/test_cursor.py
index 889061cd83..4d5db01eac 100644
--- a/tests/unit/spanner_dbapi/test_cursor.py
+++ b/tests/unit/spanner_dbapi/test_cursor.py
@@ -862,3 +862,33 @@ def test_fetchmany_retry_aborted_statements_checksums_mismatch(self):
                     cursor.fetchmany(len(row))
 
                 run_mock.assert_called_with(statement, retried=True)
+
+    def test_ddls_with_semicolon(self):
+        """
+        Check that one script with several DDL statements separated
+        with semicolons is splitted into several DDLs.
+        """
+        from google.cloud.spanner_dbapi.connection import connect
+
+        EXP_DDLS = [
+            "CREATE TABLE table_name (row_id INT64) PRIMARY KEY ()",
+            "DROP INDEX index_name",
+            "DROP TABLE table_name",
+        ]
+
+        with mock.patch(
+            "google.cloud.spanner_v1.instance.Instance.exists", return_value=True,
+        ):
+            with mock.patch(
+                "google.cloud.spanner_v1.database.Database.exists", return_value=True,
+            ):
+                connection = connect("test-instance", "test-database")
+
+        cursor = connection.cursor()
+        cursor.execute(
+            "CREATE TABLE table_name (row_id INT64) PRIMARY KEY ();"
+            "DROP INDEX index_name;\n"
+            "DROP TABLE table_name;"
+        )
+
+        self.assertEqual(connection._ddl_statements, EXP_DDLS)