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PTN000252522 not always GO:1901006 | ubiquinone-6 biosynthetic process #5226

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ValWood opened this issue May 8, 2024 · 4 comments
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@ValWood
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ValWood commented May 8, 2024

  • PTHR ID & PTN node:

coq11 | ↑is_a GO:1901006 | ubiquinone-6 biosynthetic process | IBA with PTN000252522 , S000004281

  • Sequences with problematic annotation (ID + gene/protein name):

https://www.pombase.org/gene/SPCC1840.09

  • Type of Issue: Erroneous source or erroneous propagation, or other issue

erroneous propagation.
S. pombe produces ubiquinone-10 (Coenzyme Q10) instead of ubiquinone-6

  • Add the label 'high priority' if needed. Generally high priority issues affect a lot of proteins, and annotations are incorrect (as opposed to just imprecise).
@ValWood
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ValWood commented May 8, 2024

see
https://www.pombase.org/reference/PMID:24911838
Functional conservation of coenzyme Q biosynthetic genes among yeasts, plants, and humans.
In living organisms, CoQ exists in a number of different forms with differing isoprenoid side chain lengths. For example, in humans and the fission yeast Schizosaccharomyces pombe, the CoQ side chain comprises ten isoprene units (CoQ10), whereas those in Arabidopsis thaliana and Saccharomyces cerevisiae are composed of nine (CoQ9) and six (CoQ6) units, respectively [1].

@marcfeuermann
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marcfeuermann commented May 16, 2024

Moved annotation to parent term: ubiquinone biosynthetic process

@ValWood
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ValWood commented May 16, 2024

I was just about to correct you ;)

@marcfeuermann
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Yes sorry, I've sent the message too quickly.
Copy/paste is dangerous sometimes ;-)

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