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PTN000896085 #5210

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ValWood opened this issue Apr 29, 2024 · 1 comment
Closed

PTN000896085 #5210

ValWood opened this issue Apr 29, 2024 · 1 comment
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@ValWood
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ValWood commented Apr 29, 2024

  • PTHR ID & PTN node:

PTN000896085

  • Sequences with problematic annotation (ID + gene/protein name):

https://www.pombase.org/gene/SPCC645.13 transcription elongation regulator, PHD finger Bye1
https://www.pombase.org/gene/SPAC20H4.03c general transcription elongation factor TFIIS (tfs1) S. cerevisiae DST1

  • Type of Issue: Erroneous source or erroneous propagation, or other issue

I would not transfer these. All annotation come from a single 2005 paper. The relationship between elongation and 3' end processing is complex but I don't see anything other than causaly upstream here. It isn't regutory because the regulation is through rpd1 CTD phosphorylation, but there may be some causal connection.

There seems to be some erroneous propagation too, because the S. cerevisiae genes annotated are
DST1/SPT6
but the pombe genes annotated are tfs1(DST1) and Bye1 (but not Spt6)

  • Add the label 'high priority' if needed. Generally high priority issues affect a lot of proteins, and annotations are incorrect (as opposed to just imprecise).
@marcfeuermann
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Annotation reviewed

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