forked from DataSciBurgoon/aop-ontology
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aopo.owl
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aopo.owl
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<?xml version="1.0"?>
<rdf:RDF xmlns="http://aopkb.org/aop_ontology#"
xml:base="http://aopkb.org/aop_ontology"
xmlns:obo2="http://purl.obolibrary.org/obo#"
xmlns:owl="http://www.w3.org/2002/07/owl#"
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
xmlns:hp="http://purl.obolibrary.org/obo/hp#"
xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
xmlns:Wikipedia="http://purl.obolibrary.org/obo/Wikipedia#"
xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
xmlns:bao="http://www.bioassayontology.org/bao#"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:xml="http://www.w3.org/XML/1998/namespace"
xmlns:hsapdv="http://purl.obolibrary.org/obo/hsapdv#"
xmlns:obo="http://purl.obolibrary.org/obo/"
xmlns:foaf="http://xmlns.com/foaf/0.1/"
xmlns:dc="http://purl.org/dc/elements/1.1/">
<owl:Ontology rdf:about="http://aopkb.org/aop_ontology">
<owl:imports rdf:resource="ftp://ftp.ebi.ac.uk/pub/databases/chebi/ontology/chebi.owl"/>
<owl:imports rdf:resource="https://raw.githubusercontent.com/obophenotype/human-phenotype-ontology/master/hp.owl"/>
<owl:imports rdf:resource="http://www.bioassayontology.org/bao/bao_core.owl"/>
</owl:Ontology>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Annotation properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://aopkb.org/aop_ontology#PubChemAID -->
<owl:AnnotationProperty rdf:about="http://aopkb.org/aop_ontology#PubChemAID"/>
<!-- http://aopkb.org/aop_ontology#PubChemCID -->
<owl:AnnotationProperty rdf:about="http://aopkb.org/aop_ontology#PubChemCID"/>
<!-- http://aopkb.org/aop_ontology#UniProtID -->
<owl:AnnotationProperty rdf:about="http://aopkb.org/aop_ontology#UniProtID"/>
<!-- http://purl.org/dc/elements/1.1/title -->
<owl:AnnotationProperty rdf:about="http://purl.org/dc/elements/1.1/title"/>
<!-- http://www.bioassayontology.org/bao#BAO_0002666 -->
<owl:AnnotationProperty rdf:about="http://www.bioassayontology.org/bao#BAO_0002666"/>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Object Properties
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://aopkb.org/aop_ontology#has_activated_key_event -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_activated_key_event">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_key_event"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_activation_relationship -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_activation_relationship">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_chemical_mie_relationship"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_adverse_outcome -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_adverse_outcome">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_key_event"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_adverse_outcome_pathway -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_adverse_outcome_pathway"/>
<!-- http://aopkb.org/aop_ontology#has_algorithm -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_algorithm">
<rdfs:range>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_algorithm"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#BioAssayCallAlgorithm"/>
</owl:Restriction>
</rdfs:range>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_antatomical_location -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_antatomical_location">
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">This defines the anatomical location where something occurs. For instance, hepatosteatotis occurs in the liver.</obo:IAO_0000115>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_aop_context -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_aop_context">
<rdfs:domain rdf:resource="http://aopkb.org/aop_ontology#AdverseOutcome"/>
<rdfs:domain rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
<rdfs:range rdf:resource="http://aopkb.org/aop_ontology#AopContext"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_aop_relationship -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_aop_relationship"/>
<!-- http://aopkb.org/aop_ontology#has_assay -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_assay"/>
<!-- http://aopkb.org/aop_ontology#has_base_uri -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_base_uri"/>
<!-- http://aopkb.org/aop_ontology#has_bioassay -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_bioassay">
<rdfs:range>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_bioassay"/>
<owl:someValuesFrom rdf:resource="http://www.bioassayontology.org/bao#BAO_0000015"/>
</owl:Restriction>
</rdfs:range>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_bioassay_call_algorithm -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_bioassay_call_algorithm"/>
<!-- http://aopkb.org/aop_ontology#has_chem_bio_assay_call -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_chem_bio_assay_call"/>
<!-- http://aopkb.org/aop_ontology#has_chemical_entity -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_chemical_entity">
<rdfs:range>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_chemical_entity"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24431"/>
</owl:Restriction>
</rdfs:range>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_chemical_mie_relationship -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_chemical_mie_relationship">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_aop_relationship"/>
<rdfs:range>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_aop_relationship"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#AopRelationship"/>
</owl:Restriction>
</rdfs:range>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_confidence -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_confidence">
<rdfs:domain>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_confidence"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#AdverseOutcome"/>
</owl:Restriction>
</rdfs:domain>
<rdfs:range>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_confidence"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#ConfidenceLevels"/>
</owl:Restriction>
</rdfs:range>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_deactivation_relationship -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_deactivation_relationship">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_chemical_mie_relationship"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_downstream_key_event -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_downstream_key_event">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_key_event_relationship"/>
<owl:propertyDisjointWith rdf:resource="http://aopkb.org/aop_ontology#has_upstream_key_event"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_downstream_key_event_modulation -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_downstream_key_event_modulation">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_modulation"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_evidence -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_evidence"/>
<!-- http://aopkb.org/aop_ontology#has_human_phenotype -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_human_phenotype"/>
<!-- http://aopkb.org/aop_ontology#has_inactivated_key_event -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_inactivated_key_event">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_key_event"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_intermediate_event -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_intermediate_event"/>
<!-- http://aopkb.org/aop_ontology#has_key_event -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_key_event">
<rdfs:range rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_key_event_relationship -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_key_event_relationship">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_aop_relationship"/>
<rdfs:range>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_key_event_relationship"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:Restriction>
</rdfs:range>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_key_event_type -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_key_event_type"/>
<!-- http://aopkb.org/aop_ontology#has_mie_modulation -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_mie_modulation">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_modulation"/>
<rdfs:range>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_mie_modulation"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#Modulation"/>
</owl:Restriction>
</rdfs:range>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_modulation -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_modulation"/>
<!-- http://aopkb.org/aop_ontology#has_molecular_initiating_event -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_molecular_initiating_event">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_key_event"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_pathological_entity -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_pathological_entity">
<rdfs:subPropertyOf rdf:resource="http://www.w3.org/2002/07/owl#topObjectProperty"/>
<rdfs:range rdf:resource="http://purl.obolibrary.org/obo/MPATH_0"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_point_of_departure -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_point_of_departure">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_quantitative_measure"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_pubchem_assay -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_pubchem_assay">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_pubchem_entity"/>
<rdfs:domain>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_pubchem_assay"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#AopEntity"/>
</owl:Restriction>
</rdfs:domain>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_pubchem_compound -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_pubchem_compound">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_pubchem_entity"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_pubchem_entity -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_pubchem_entity"/>
<!-- http://aopkb.org/aop_ontology#has_pubchem_substance -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_pubchem_substance">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_pubchem_entity"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_quantitative_measure -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_quantitative_measure"/>
<!-- http://aopkb.org/aop_ontology#has_risk_specific_dose -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_risk_specific_dose">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_quantitative_measure"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_species -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_species">
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">This is the species that the class is relevant to.</obo:IAO_0000115>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_threshold_response_value -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_threshold_response_value">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_quantitative_measure"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_upstream_key_event -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_upstream_key_event">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_key_event_relationship"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#has_upstream_key_event_modulation -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#has_upstream_key_event_modulation">
<rdfs:subPropertyOf rdf:resource="http://aopkb.org/aop_ontology#has_modulation"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#is_adverse_outcome -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#is_adverse_outcome"/>
<!-- http://aopkb.org/aop_ontology#is_associated_with_key_event -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#is_associated_with_key_event">
<rdfs:range>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#is_associated_with_key_event"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:Restriction>
</rdfs:range>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#is_biological_macromolecule -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#is_biological_macromolecule"/>
<!-- http://aopkb.org/aop_ontology#is_causal_for -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#is_causal_for"/>
<!-- http://aopkb.org/aop_ontology#is_key_event_component_of -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#is_key_event_component_of">
<rdfs:domain rdf:resource="http://aopkb.org/aop_ontology#KeyEventComponent"/>
<rdfs:range rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:ObjectProperty>
<!-- http://aopkb.org/aop_ontology#is_molecular_initiating_event -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#is_molecular_initiating_event"/>
<!-- http://aopkb.org/aop_ontology#is_pathological_entity -->
<owl:ObjectProperty rdf:about="http://aopkb.org/aop_ontology#is_pathological_entity"/>
<!--
///////////////////////////////////////////////////////////////////////////////////////
//
// Classes
//
///////////////////////////////////////////////////////////////////////////////////////
-->
<!-- http://aopkb.org/aop_ontology#AO-DecreasedFecundity -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#AO-DecreasedFecundity">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#ReproductiveAdverseOutcome"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#AO-NeuralTubeDefect -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#AO-NeuralTubeDefect">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#DevelopmentalAdverseOutcome"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#AO-Steatosis -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#AO-Steatosis">
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_inactivated_key_event"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#HSD17B4"/>
</owl:Restriction>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#LiverAdverseOutcome"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#is_pathological_entity"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/MPATH_622"/>
</owl:Restriction>
</rdfs:subClassOf>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#ActivatedAssayCall -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#ActivatedAssayCall">
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_activated_key_event"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:Restriction>
</owl:equivalentClass>
<obo:IAO_0000115>Assay that is activated at a given exposure concentration/dose.</obo:IAO_0000115>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#Activation -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#Activation">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#Modulation"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#ActivityActivation -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#ActivityActivation">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#Activation"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#ActivityDeactivation -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#ActivityDeactivation">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#Deactivation"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#AdverseOutcome -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#AdverseOutcome">
<rdfs:label>Adverse Outcome</rdfs:label>
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#AopEntity"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Any undesired and harmful effect or outcome.</obo:IAO_0000115>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#AdverseOutcomePathway -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#AdverseOutcomePathway">
<rdfs:label>Adverse Outcome Pathway</rdfs:label>
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_aop_relationship"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#AopRelationship"/>
</owl:Restriction>
</owl:equivalentClass>
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_adverse_outcome"/>
<owl:qualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:qualifiedCardinality>
<owl:onClass rdf:resource="http://aopkb.org/aop_ontology#AdverseOutcome"/>
</owl:Restriction>
</owl:equivalentClass>
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_chemical_mie_relationship"/>
<owl:qualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:qualifiedCardinality>
<owl:onClass rdf:resource="http://aopkb.org/aop_ontology#ChemicalMIERelationship"/>
</owl:Restriction>
</owl:equivalentClass>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_confidence"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#Confidence"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo2:Definition rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An Adverse Outcome Pathway (AOP) is a conceptual framework that portrays existing knowledge concerning the linkage between two anchor points - the Molecular Initiating Event (MIE), and an Adverse Outcome (AO), connected by a chain of Key Events (KE) and the relationships between them (KER).</obo2:Definition>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#Akt2 -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#Akt2">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#AopContext -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#AopContext">
<obo2:Definition>The context for an AopEntity. Typically these are cell types, organs, life stages, etc.</obo2:Definition>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#AopEntity -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#AopEntity">
<obo2:Definition rdf:datatype="http://www.w3.org/2001/XMLSchema#string">An entity that is part of an adverse outcome pathway</obo2:Definition>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#AopRelationship -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#AopRelationship"/>
<!-- http://aopkb.org/aop_ontology#Aromatase -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#Aromatase">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#BioAssayCallAlgorithm -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#BioAssayCallAlgorithm">
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">This is the algorithm that is used to make a "hit" call from a bioassay. Generally, there is some type of decision rule that is used by an algorithm to make this call.</obo:IAO_0000115>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#CellTypeContext -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#CellTypeContext">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#AopContext"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#CellularOrganelleContext -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#CellularOrganelleContext">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#AopContext"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#ChemBioAssayResults -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#ChemBioAssayResults">
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_bioassay_call_algorithm"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#BioAssayCallAlgorithm"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://www.bioassayontology.org/bao#BAO_0000209"/>
<owl:someValuesFrom rdf:resource="http://www.bioassayontology.org/bao#BAO_0000040"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">This class represents a hit call (ChemBioAssayCall) from a specific assay result at a specific chemical concentration (measure group) using a specific BioAssayCallAlgorithm. In other words, this is a collection class.</obo:IAO_0000115>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#ChemicalMIERelationship -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#ChemicalMIERelationship">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#AopRelationship"/>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_chemical_entity"/>
<owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24431"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_evidence"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#Evidence"/>
</owl:Restriction>
</rdfs:subClassOf>
<rdfs:subClassOf>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_molecular_initiating_event"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#MolecularInitiatingEvent"/>
</owl:Restriction>
</rdfs:subClassOf>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">This class encodes a relationship between a chemical and a molecular initiating event. It is possible that a given chemical and MIE have more than one relationship. For instance, a selective estrogen receptor modulator (SERM) may activate and deactivate estrogen receptor activity, resulting in more than one relationship.</obo:IAO_0000115>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#Confidence -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#Confidence">
<obo2:Definition>An individual's level of support for a concept being true or a fact.</obo2:Definition>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#ConfidenceLevels -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#ConfidenceLevels">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#QualitativeMeasures"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#Deactivation -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#Deactivation">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#Modulation"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#DecreasedFecundity -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#DecreasedFecundity">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#ReproductiveToxicologyAOP"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#DevelopmentalAdverseOutcome -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#DevelopmentalAdverseOutcome">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#AdverseOutcome"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#DevelopmentalToxicologyAOP -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#DevelopmentalToxicologyAOP">
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_adverse_outcome"/>
<owl:qualifiedCardinality rdf:datatype="http://www.w3.org/2001/XMLSchema#nonNegativeInteger">1</owl:qualifiedCardinality>
<owl:onClass rdf:resource="http://aopkb.org/aop_ontology#DevelopmentalAdverseOutcome"/>
</owl:Restriction>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#AdverseOutcomePathway"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#DiabetesMellitusType2 -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#DiabetesMellitusType2">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#DiseaseAOP"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#DiseaseAOP -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#DiseaseAOP">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#AdverseOutcomePathway"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#DiseaseAdverseOutcome -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#DiseaseAdverseOutcome">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#AdverseOutcome"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#Estradiol -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#Estradiol">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#Estrogen_receptor_alpha -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#Estrogen_receptor_alpha">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#Evidence -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#Evidence"/>
<!-- http://aopkb.org/aop_ontology#ExpressionActivation -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#ExpressionActivation">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#Activation"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#ExpressionDeactivation -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#ExpressionDeactivation">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#Deactivation"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#FXR -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#FXR">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#Fecundity -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#Fecundity">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#GSK3 -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#GSK3">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#HSD17B4 -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#HSD17B4">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#HighConfidence -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#HighConfidence">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#ConfidenceLevels"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#High_Confidence -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#High_Confidence">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#Confidence"/>
<obo2:Definition>A high level of confidence in the truth or factual nature of a concept. Generally one may think of this as spanning from 80% to 90% certainty. Based on the IPCC Uncertainty Guidance Note and https://www.ipcc.ch/publications_and_data/ar4/wg1/en/ch1s1-6.html</obo2:Definition>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#Hoxb1 -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#Hoxb1">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#Hoxb1_gene -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#Hoxb1_gene">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#IRS1 -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#IRS1">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#InactivatedAssayCall -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#InactivatedAssayCall">
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_inactivated_key_event"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:Restriction>
</owl:equivalentClass>
<obo:IAO_0000115>Assay that is inactivated at a given concentration/dose</obo:IAO_0000115>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#IntermediateEvent -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#IntermediateEvent">
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#KeyEventType"/>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#KeyEvent -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#KeyEvent">
<rdfs:label>Key Event</rdfs:label>
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_aop_context"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#AopContext"/>
</owl:Restriction>
</owl:equivalentClass>
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_key_event_type"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#KeyEventType"/>
</owl:Restriction>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#AopEntity"/>
<owl:disjointWith rdf:resource="http://aopkb.org/aop_ontology#KeyEventComponent"/>
<obo:IAO_0000115 rdf:datatype="http://www.w3.org/2001/XMLSchema#string">A necessary event that must occur for an adverse outcome to develop or be triggered.</obo:IAO_0000115>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#KeyEventComponent -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#KeyEventComponent">
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_aop_context"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#AopContext"/>
</owl:Restriction>
</owl:equivalentClass>
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#is_biological_macromolecule"/>
<owl:someValuesFrom rdf:resource="http://www.bioassayontology.org/bao#BAO_0003111"/>
</owl:Restriction>
</owl:equivalentClass>
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#is_key_event_component_of"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#KeyEvent"/>
</owl:Restriction>
</owl:equivalentClass>
<rdfs:subClassOf rdf:resource="http://aopkb.org/aop_ontology#AopEntity"/>
<obo2:Definition>Key Event Components are measurable biological entities that make up a Key Event. They likely represent either different sequential steps of the Key Event (e.g., the different steps of fatty acid beta oxidation), or they represent parallel steps that all contribute to the Key Event.</obo2:Definition>
</owl:Class>
<!-- http://aopkb.org/aop_ontology#KeyEventRelationship -->
<owl:Class rdf:about="http://aopkb.org/aop_ontology#KeyEventRelationship">
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_downstream_key_event"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#AopEntity"/>
</owl:Restriction>
</owl:equivalentClass>
<owl:equivalentClass>
<owl:Restriction>
<owl:onProperty rdf:resource="http://aopkb.org/aop_ontology#has_downstream_key_event_modulation"/>
<owl:someValuesFrom rdf:resource="http://aopkb.org/aop_ontology#Modulation"/>
</owl:Restriction>