DownstreamAnalysis.ipynb

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    "# Downstream analysis\n",
    "We create a vcf file containing small and structral variants annotated with their AF. Here we are going to go through how to explore those variants. The following table describes the metadata tagged for each variant.\n",
    "\n",
    "\n",
    "| Metadata      | Description |\n",
    "| -- |:-----------:|\n",
    "| AC | Allele count in genotypes|\n",
    "| AC_Het | Allele counts in homozygous genotypes|\n",
    "| AC_Hom | Allele counts in heterozygous genotypes|\n",
    "| AC_Hemi | Allele counts in hemizygous genotypes|\n",
    "| AF | Allele frequency |\n",
    "| MAF | Minor Allele frequency |\n",
    "| NS | Number of samples with data   |\n",
    "| AN | Total number of alleles in called genotypes |\n",
    "| HWE | Hardy-Weinberg equilibrium |\n",
    "| ExcHet | Test excess heterozygosity; 1=good, 0=bad |\n",
    "\n",
    "\n",
    "Let's first check a file called \"samples.csv\" containing ethnici information of the 273 samples. The following command print the first 10 samples"
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      "┌────────────┬────────────────────────────────────────┬──────────────────┐\n",
      "│\u001b[0msample      \u001b[0m│\u001b[0mpopulation                              \u001b[0m│\u001b[0msuper_population  \u001b[0m│\n",
      "├────────────┼────────────────────────────────────────┼──────────────────┤\n",
      "│abh100      │Abkhasian_in_Abkhazia_or_Russia_(SGDP)  │EUR               │\n",
      "│abh107      │Abkhasian_in_Abkhazia_or_Russia_(SGDP)  │EUR               │\n",
      "│ALB212      │Albanian_in_Albania_(SGDP)              │EUR               │\n",
      "│Ale14       │Tlingit_in_Russia_(SGDP)                │EUR               │\n",
      "│Ale20       │Aleut_in_Russia_(SGDP)                  │EUR               │\n",
      "│Ale22       │Aleut_in_Russia_(SGDP)                  │EUR               │\n",
      "│Ale32       │Tlingit_in_Russia_(SGDP)                │EUR               │\n",
      "│altai363p   │Altaian_in_Russia_(SGDP)                │EUR               │\n",
      "│armenia293  │Armenian_in_Armenia_(SGDP)              │EUR               │\n",
      "└────────────┴────────────────────────────────────────┴──────────────────┘\n"
     ]
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   "source": [
    "%%bash\n",
    "cat index/SGDP/samples.csv |head|tr -s ',' $'\\t'| tr -s ' ' '_'| scripts/prettytable 3"
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   "source": [
    "The commands below count the number of samples per breed"
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      "┌──────────────────┬───────┐\n",
      "│\u001b[0msuper_population  \u001b[0m│\u001b[0mcount  \u001b[0m│\n",
      "├──────────────────┼───────┤\n",
      "│ASIA              │114    │\n",
      "│EUR               │75     │\n",
      "│AFR               │44     │\n",
      "│AUS               │20     │\n",
      "│N_AMR             │12     │\n",
      "│S_AMR             │11     │\n",
      "└──────────────────┴───────┘\n"
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   "source": [
    "%%bash\n",
    "cut -f3 -d, index/SGDP/samples.csv|tail -n+2 |tr -s ' ' '_' |sort |uniq -c| awk '{print $2\"\\t\"$1}' |sort -k2,2nr > tmp\n",
    "cat <(echo -e \"super_population\\tcount\") tmp | scripts/prettytable 2"
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    "# Hail\n",
    "Although bcftools is very helpful and fast but it is hard to do complex tasks with it. Here we are suggesting using Hail to be able explore the population genotyping results and get meaningful results. Hail is a python library for genomic data expoloration. It creates a matrix table for vcf files which is very similar to R dataframes.\n",
    "\n",
    "So let's do some coding by intializing Hail engine"
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      "WARNING: An illegal reflective access operation has occurred\n",
      "WARNING: Illegal reflective access by org.apache.spark.unsafe.Platform (file:/home/mshokrof/miniconda3/envs/cattle_sv2/lib/python3.9/site-packages/pyspark/jars/spark-unsafe_2.12-3.1.3.jar) to constructor java.nio.DirectByteBuffer(long,int)\n",
      "WARNING: Please consider reporting this to the maintainers of org.apache.spark.unsafe.Platform\n",
      "WARNING: Use --illegal-access=warn to enable warnings of further illegal reflective access operations\n",
      "WARNING: All illegal access operations will be denied in a future release\n"
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     "text": [
      "2023-03-27 11:29:32.190 WARN  NativeCodeLoader:60 - Unable to load native-hadoop library for your platform... using builtin-java classes where applicable\n"
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      "Setting default log level to \"WARN\".\n",
      "To adjust logging level use sc.setLogLevel(newLevel). For SparkR, use setLogLevel(newLevel).\n",
      "Running on Apache Spark version 3.1.3\n",
      "SparkUI available at http://c3-52.farm.cse.ucdavis.edu:4040\n",
      "Welcome to\n",
      "     __  __     <>__\n",
      "    / /_/ /__  __/ /\n",
      "   / __  / _ `/ / /\n",
      "  /_/ /_/\\_,_/_/_/   version 0.2.107-2387bb00ceee\n",
      "LOGGING: writing to /home/mshokrof/TheGreatGenotyper/hail-20230327-1129-0.2.107-2387bb00ceee.log\n"
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Possible fixes:\\n\"+\n     \"</p>\\n\"+\n     \"<ul>\\n\"+\n     \"<li>re-rerun `output_notebook()` to attempt to load from CDN again, or</li>\\n\"+\n     \"<li>use INLINE resources instead, as so:</li>\\n\"+\n     \"</ul>\\n\"+\n     \"<code>\\n\"+\n     \"from bokeh.resources import INLINE\\n\"+\n     \"output_notebook(resources=INLINE)\\n\"+\n     \"</code>\\n\"+\n     \"</div>\"}};\n\n  function display_loaded() {\n    var el = document.getElementById(\"1001\");\n    if (el != null) {\n      el.textContent = \"BokehJS is loading...\";\n    }\n    if (root.Bokeh !== undefined) {\n      if (el != null) {\n        el.textContent = \"BokehJS \" + root.Bokeh.version + \" successfully loaded.\";\n      }\n    } else if (Date.now() < root._bokeh_timeout) {\n      setTimeout(display_loaded, 100)\n    }\n  }\n\n\n  function run_callbacks() {\n    try {\n      root._bokeh_onload_callbacks.forEach(function(callback) {\n        if (callback != null)\n          callback();\n      });\n    } finally {\n      delete root._bokeh_onload_callbacks\n    }\n    console.debug(\"Bokeh: all callbacks have finished\");\n  }\n\n  function load_libs(css_urls, js_urls, callback) {\n    if (css_urls == null) css_urls = [];\n    if (js_urls == null) js_urls = [];\n\n    root._bokeh_onload_callbacks.push(callback);\n    if (root._bokeh_is_loading > 0) {\n      console.debug(\"Bokeh: BokehJS is being loaded, scheduling callback at\", now());\n      return null;\n    }\n    if (js_urls == null || js_urls.length === 0) {\n      run_callbacks();\n      return null;\n    }\n    console.debug(\"Bokeh: BokehJS not loaded, scheduling load and callback at\", now());\n    root._bokeh_is_loading = css_urls.length + js_urls.length;\n\n    function on_load() {\n      root._bokeh_is_loading--;\n      if (root._bokeh_is_loading === 0) {\n        console.debug(\"Bokeh: all BokehJS libraries/stylesheets loaded\");\n        run_callbacks()\n      }\n    }\n\n    function on_error() {\n      console.error(\"failed to load \" + url);\n    }\n\n    for (var i = 0; i < css_urls.length; i++) {\n      var url = css_urls[i];\n      const element = document.createElement(\"link\");\n      element.onload = on_load;\n      element.onerror = on_error;\n      element.rel = \"stylesheet\";\n      element.type = \"text/css\";\n      element.href = url;\n      console.debug(\"Bokeh: injecting link tag for BokehJS stylesheet: \", url);\n      document.body.appendChild(element);\n    }\n\n    for (var i = 0; i < js_urls.length; i++) {\n      var url = js_urls[i];\n      var element = document.createElement('script');\n      element.onload = on_load;\n      element.onerror = on_error;\n      element.async = false;\n      element.src = url;\n      console.debug(\"Bokeh: injecting script tag for BokehJS library: \", url);\n      document.head.appendChild(element);\n    }\n  };var element = document.getElementById(\"1001\");\n  if (element == null) {\n    console.error(\"Bokeh: ERROR: autoload.js configured with elementid '1001' but no matching script tag was found. \")\n    return false;\n  }\n\n  function inject_raw_css(css) {\n    const element = document.createElement(\"style\");\n    element.appendChild(document.createTextNode(css));\n    document.body.appendChild(element);\n  }\n\n  \n  var js_urls = [\"https://cdn.pydata.org/bokeh/release/bokeh-1.4.0.min.js\", \"https://cdn.pydata.org/bokeh/release/bokeh-widgets-1.4.0.min.js\", \"https://cdn.pydata.org/bokeh/release/bokeh-tables-1.4.0.min.js\", \"https://cdn.pydata.org/bokeh/release/bokeh-gl-1.4.0.min.js\"];\n  var css_urls = [];\n  \n\n  var inline_js = [\n    function(Bokeh) {\n      Bokeh.set_log_level(\"info\");\n    },\n    function(Bokeh) {\n    \n    \n    }\n  ];\n\n  function run_inline_js() {\n    \n    if (root.Bokeh !== undefined || force === true) {\n      \n    for (var i = 0; i < inline_js.length; i++) {\n      inline_js[i].call(root, root.Bokeh);\n    }\n    if (force === true) {\n        display_loaded();\n      }} else if (Date.now() < root._bokeh_timeout) {\n      setTimeout(run_inline_js, 100);\n    } else if (!root._bokeh_failed_load) {\n      console.log(\"Bokeh: BokehJS failed to load within specified timeout.\");\n      root._bokeh_failed_load = true;\n    } else if (force !== true) {\n      var cell = $(document.getElementById(\"1001\")).parents('.cell').data().cell;\n      cell.output_area.append_execute_result(NB_LOAD_WARNING)\n    }\n\n  }\n\n  if (root._bokeh_is_loading === 0) {\n    console.debug(\"Bokeh: BokehJS loaded, going straight to plotting\");\n    run_inline_js();\n  } else {\n    load_libs(css_urls, js_urls, function() {\n      console.debug(\"Bokeh: BokehJS plotting callback run at\", now());\n      run_inline_js();\n    });\n  }\n}(window));"
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "import hail as hl\n",
    "hl.init()\n",
    "from hail.plot import show\n",
    "from pprint import pprint\n",
    "hl.plot.output_notebook()"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "90f45585-3017-4d17-b3fb-e550c878c3f6",
   "metadata": {},
   "source": [
    "Now we are going to load the vcf and samples information to create Hail Matrix table"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 20,
   "id": "cb96476a-782c-4f55-bea7-d5ed0c7364bb",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "2023-03-27 11:45:20.685 Hail: INFO: wrote table with 277 rows in 1 partition to /tmp/persist_table4sDFsWhUO1\n",
      "2023-03-27 11:45:20.867 Hail: INFO: Reading table to impute column types\n",
      "2023-03-27 11:45:21.086 Hail: INFO: Finished type imputation\n",
      "  Loading field 'sample' as type str (imputed)\n",
      "  Loading field 'population' as type str (imputed)\n",
      "  Loading field 'super_population' as type str (imputed)\n"
     ]
    }
   ],
   "source": [
    "vcf=\"test_output/merged.vcf.bgz\"\n",
    "samplesInfo=\"index/SGDP/samples.updated.csv\"\n",
    "\n",
    "mt = hl.import_vcf(vcf,reference_genome=\"GRCh38\")\n",
    "table = (hl.import_table(samplesInfo, impute=True,delimiter=\",\")\n",
    "         .key_by('sample'))\n",
    "mt = mt.annotate_cols(population = table[mt.s])"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "821f1090-c61b-4b52-a7f3-537c4dc4014a",
   "metadata": {},
   "source": [
    "Lets see how the hail matrix table is organized"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 18,
   "id": "8d27461f-4b01-461d-b543-72c8f5df69a7",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table><thead><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"14\"><div style=\"text-align: left;\"></div></td></tr><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"14\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">info</div></td></tr><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">locus</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">alleles</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">rsid</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">qual</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">filters</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AF</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">UK</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AK</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">MA</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">ID</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AN</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AC</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">NS</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AC_Hom</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AC_Het</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AC_Hemi</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">MAF</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">HWE</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">ExcHet</div></td></tr><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">locus&lt;GRCh38&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;str&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">str</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">float64</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">set&lt;str&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;float64&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">int32</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">int32</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;str&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">int32</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">int32</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">float64</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;float64&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;float64&gt;</td></tr>\n",
       "</thead><tbody><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13224360</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;G&quot;,&quot;A&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13224360-SNV-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[4.42e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">31</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[31,0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13224360-SNV-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[244]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[32]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[212]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">4.42e-01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.45e-21]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.31e-21]</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13224428</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;C&quot;,&quot;T&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13224428-SNV-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[3.99e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">8</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[13,4]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13224428-SNV-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[220]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[108]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[112]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">3.99e-01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.19e-02]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[9.97e-01]</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13224943</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;C&quot;,&quot;CA&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13224943-INS-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[9.91e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">44</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[24,11]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13224943-INS-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[547]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[542]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[5]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">9.06e-03</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.00e+00]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[9.82e-01]</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13229905</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;A&quot;,&quot;G&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13229905-SNV-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[9.98e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">18</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[8,29]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13229905-SNV-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[551]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[550]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1.81e-03</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.00e+00]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.00e+00]</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13231128</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;A&quot;,&quot;G&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13231128-SNV-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[7.37e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">60</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[31,0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13231128-SNV-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[407]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[270]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[137]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.63e-01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[7.01e-07]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[3.92e-07]</td></tr>\n",
       "</tbody></table><p style=\"background: #fdd; padding: 0.4em;\">showing top 5 rows</p>\n"
      ],
      "text/plain": [
       "+----------------+------------+--------------------------+-----------+\n",
       "| locus          | alleles    | rsid                     |      qual |\n",
       "+----------------+------------+--------------------------+-----------+\n",
       "| locus<GRCh38>  | array<str> | str                      |   float64 |\n",
       "+----------------+------------+--------------------------+-----------+\n",
       "| chr21:13224360 | [\"G\",\"A\"]  | \"chr21-13224360-SNV-0-1\" | -1.00e+01 |\n",
       "| chr21:13224428 | [\"C\",\"T\"]  | \"chr21-13224428-SNV-0-1\" | -1.00e+01 |\n",
       "| chr21:13224943 | [\"C\",\"CA\"] | \"chr21-13224943-INS-0-1\" | -1.00e+01 |\n",
       "| chr21:13229905 | [\"A\",\"G\"]  | \"chr21-13229905-SNV-0-1\" | -1.00e+01 |\n",
       "| chr21:13231128 | [\"A\",\"G\"]  | \"chr21-13231128-SNV-0-1\" | -1.00e+01 |\n",
       "+----------------+------------+--------------------------+-----------+\n",
       "\n",
       "+----------+----------------+---------+--------------+---------+\n",
       "| filters  | info.AF        | info.UK | info.AK      | info.MA |\n",
       "+----------+----------------+---------+--------------+---------+\n",
       "| set<str> | array<float64> |   int32 | array<int32> |   int32 |\n",
       "+----------+----------------+---------+--------------+---------+\n",
       "| {}       | [4.42e-01]     |      31 | [31,0]       |       0 |\n",
       "| {}       | [3.99e-01]     |       8 | [13,4]       |       0 |\n",
       "| {}       | [9.91e-01]     |      44 | [24,11]      |       0 |\n",
       "| {}       | [9.98e-01]     |      18 | [8,29]       |       0 |\n",
       "| {}       | [7.37e-01]     |      60 | [31,0]       |       0 |\n",
       "+----------+----------------+---------+--------------+---------+\n",
       "\n",
       "+----------------------------+---------+--------------+---------+--------------+\n",
       "| info.ID                    | info.AN | info.AC      | info.NS | info.AC_Hom  |\n",
       "+----------------------------+---------+--------------+---------+--------------+\n",
       "| array<str>                 |   int32 | array<int32> |   int32 | array<int32> |\n",
       "+----------------------------+---------+--------------+---------+--------------+\n",
       "| [\"chr21-13224360-SNV-0-1\"] |     552 | [244]        |     276 | [32]         |\n",
       "| [\"chr21-13224428-SNV-0-1\"] |     552 | [220]        |     276 | [108]        |\n",
       "| [\"chr21-13224943-INS-0-1\"] |     552 | [547]        |     276 | [542]        |\n",
       "| [\"chr21-13229905-SNV-0-1\"] |     552 | [551]        |     276 | [550]        |\n",
       "| [\"chr21-13231128-SNV-0-1\"] |     552 | [407]        |     276 | [270]        |\n",
       "+----------------------------+---------+--------------+---------+--------------+\n",
       "\n",
       "+--------------+--------------+----------+----------------+----------------+\n",
       "| info.AC_Het  | info.AC_Hemi | info.MAF | info.HWE       | info.ExcHet    |\n",
       "+--------------+--------------+----------+----------------+----------------+\n",
       "| array<int32> | array<int32> |  float64 | array<float64> | array<float64> |\n",
       "+--------------+--------------+----------+----------------+----------------+\n",
       "| [212]        | [0]          | 4.42e-01 | [1.45e-21]     | [1.31e-21]     |\n",
       "| [112]        | [0]          | 3.99e-01 | [1.19e-02]     | [9.97e-01]     |\n",
       "| [5]          | [0]          | 9.06e-03 | [1.00e+00]     | [9.82e-01]     |\n",
       "| [1]          | [0]          | 1.81e-03 | [1.00e+00]     | [1.00e+00]     |\n",
       "| [137]        | [0]          | 2.63e-01 | [7.01e-07]     | [3.92e-07]     |\n",
       "+--------------+--------------+----------+----------------+----------------+\n",
       "showing top 5 rows"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "mt.rows().show(5)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "id": "2657f025-5c38-40f8-85b2-a8bec8aaea6b",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table><thead><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td></tr><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">'abh100'</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">'abh107'</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">'ALB212'</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">'Ale14'</div></td></tr><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">locus</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">alleles</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">GT</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">GT</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">GT</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">GT</div></td></tr><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">locus&lt;GRCh38&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;str&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">call</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">call</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">call</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">call</td></tr>\n",
       "</thead><tbody><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13224360</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;G&quot;,&quot;A&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0/0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0/0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0/1</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0/1</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13224428</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;C&quot;,&quot;T&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0/0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0/0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0/1</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0/0</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13224943</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;C&quot;,&quot;CA&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1/1</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1/1</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1/1</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1/1</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13229905</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;A&quot;,&quot;G&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1/1</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1/1</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1/1</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1/1</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13231128</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;A&quot;,&quot;G&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0/1</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1/1</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1/1</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0/1</td></tr>\n",
       "</tbody></table><p style=\"background: #fdd; padding: 0.4em;\">showing top 5 rows</p>\n",
       "<p style=\"background: #fdd; padding: 0.4em;\">showing the first 4 of 276 columns</p>\n"
      ],
      "text/plain": [
       "+----------------+------------+-------------+-------------+-------------+\n",
       "| locus          | alleles    | 'abh100'.GT | 'abh107'.GT | 'ALB212'.GT |\n",
       "+----------------+------------+-------------+-------------+-------------+\n",
       "| locus<GRCh38>  | array<str> | call        | call        | call        |\n",
       "+----------------+------------+-------------+-------------+-------------+\n",
       "| chr21:13224360 | [\"G\",\"A\"]  | 0/0         | 0/0         | 0/1         |\n",
       "| chr21:13224428 | [\"C\",\"T\"]  | 0/0         | 0/0         | 0/1         |\n",
       "| chr21:13224943 | [\"C\",\"CA\"] | 1/1         | 1/1         | 1/1         |\n",
       "| chr21:13229905 | [\"A\",\"G\"]  | 1/1         | 1/1         | 1/1         |\n",
       "| chr21:13231128 | [\"A\",\"G\"]  | 0/1         | 1/1         | 1/1         |\n",
       "+----------------+------------+-------------+-------------+-------------+\n",
       "\n",
       "+------------+\n",
       "| 'Ale14'.GT |\n",
       "+------------+\n",
       "| call       |\n",
       "+------------+\n",
       "| 0/1        |\n",
       "| 0/0        |\n",
       "| 1/1        |\n",
       "| 1/1        |\n",
       "| 0/1        |\n",
       "+------------+\n",
       "showing top 5 rows\n",
       "showing the first 4 of 276 columns"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "mt.GT.show(5)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 21,
   "id": "65bcca26-23e1-44ed-83c2-cdd10a564749",
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "{'Africa': 44, 'America': 22, 'Central Asia and Siberia': 25, 'East Asia': 47, 'Oceania': 25, 'South Asia': 35, 'West Eurasia': 75, None: 3}\n"
     ]
    }
   ],
   "source": [
    "samplesPercohort=mt.aggregate_cols(hl.agg.counter(mt.population.super_population))\n",
    "print(samplesPercohort)"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "720f3c92-403b-433d-9f5d-67b328ab3e11",
   "metadata": {},
   "source": [
    "### Stratify population allele frequency\n",
    "Here we are trying to answer questions like which variants are frequent in the african populations. We are going to calculate allele frequencies per super population.\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 33,
   "id": "f44441f9-e8fe-44ab-8b63-05c42ed8c711",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table><thead><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"14\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td></tr><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"14\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">info</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td></tr><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">locus</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">alleles</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">rsid</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">qual</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">filters</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AF</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">UK</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AK</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">MA</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">ID</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AN</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AC</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">NS</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AC_Hom</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AC_Het</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AC_Hemi</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">MAF</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">HWE</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">ExcHet</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AF_AFR</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AF_EUR</div></td></tr><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">locus&lt;GRCh38&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;str&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">str</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">float64</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">set&lt;str&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;float64&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">int32</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">int32</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;str&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">int32</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">int32</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">float64</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;float64&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;float64&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">float64</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">float64</td></tr>\n",
       "</thead><tbody><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13224360</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;G&quot;,&quot;A&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13224360-SNV-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[4.42e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">31</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[31,0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13224360-SNV-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[244]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[32]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[212]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">4.42e-01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.45e-21]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.31e-21]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.09e+00</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1.41e+00</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13224428</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;C&quot;,&quot;T&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13224428-SNV-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[3.99e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">8</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[13,4]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13224428-SNV-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[220]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[108]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[112]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">3.99e-01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.19e-02]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[9.97e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.68e+00</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">9.60e-01</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13224943</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;C&quot;,&quot;CA&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13224943-INS-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[9.91e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">44</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[24,11]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13224943-INS-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[547]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[542]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[5]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">9.06e-03</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.00e+00]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[9.82e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">4.00e+00</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">3.89e+00</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13229905</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;A&quot;,&quot;G&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13229905-SNV-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[9.98e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">18</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[8,29]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13229905-SNV-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[551]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[550]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1.81e-03</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.00e+00]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.00e+00]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">4.00e+00</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">4.00e+00</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13231128</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;A&quot;,&quot;G&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13231128-SNV-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[7.37e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">60</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[31,0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13231128-SNV-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[407]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[270]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[137]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.63e-01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[7.01e-07]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[3.92e-07]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">3.27e+00</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.77e+00</td></tr>\n",
       "</tbody></table><p style=\"background: #fdd; padding: 0.4em;\">showing top 5 rows</p>\n"
      ],
      "text/plain": [
       "+----------------+------------+--------------------------+-----------+\n",
       "| locus          | alleles    | rsid                     |      qual |\n",
       "+----------------+------------+--------------------------+-----------+\n",
       "| locus<GRCh38>  | array<str> | str                      |   float64 |\n",
       "+----------------+------------+--------------------------+-----------+\n",
       "| chr21:13224360 | [\"G\",\"A\"]  | \"chr21-13224360-SNV-0-1\" | -1.00e+01 |\n",
       "| chr21:13224428 | [\"C\",\"T\"]  | \"chr21-13224428-SNV-0-1\" | -1.00e+01 |\n",
       "| chr21:13224943 | [\"C\",\"CA\"] | \"chr21-13224943-INS-0-1\" | -1.00e+01 |\n",
       "| chr21:13229905 | [\"A\",\"G\"]  | \"chr21-13229905-SNV-0-1\" | -1.00e+01 |\n",
       "| chr21:13231128 | [\"A\",\"G\"]  | \"chr21-13231128-SNV-0-1\" | -1.00e+01 |\n",
       "+----------------+------------+--------------------------+-----------+\n",
       "\n",
       "+----------+----------------+---------+--------------+---------+\n",
       "| filters  | info.AF        | info.UK | info.AK      | info.MA |\n",
       "+----------+----------------+---------+--------------+---------+\n",
       "| set<str> | array<float64> |   int32 | array<int32> |   int32 |\n",
       "+----------+----------------+---------+--------------+---------+\n",
       "| {}       | [4.42e-01]     |      31 | [31,0]       |       0 |\n",
       "| {}       | [3.99e-01]     |       8 | [13,4]       |       0 |\n",
       "| {}       | [9.91e-01]     |      44 | [24,11]      |       0 |\n",
       "| {}       | [9.98e-01]     |      18 | [8,29]       |       0 |\n",
       "| {}       | [7.37e-01]     |      60 | [31,0]       |       0 |\n",
       "+----------+----------------+---------+--------------+---------+\n",
       "\n",
       "+----------------------------+---------+--------------+---------+--------------+\n",
       "| info.ID                    | info.AN | info.AC      | info.NS | info.AC_Hom  |\n",
       "+----------------------------+---------+--------------+---------+--------------+\n",
       "| array<str>                 |   int32 | array<int32> |   int32 | array<int32> |\n",
       "+----------------------------+---------+--------------+---------+--------------+\n",
       "| [\"chr21-13224360-SNV-0-1\"] |     552 | [244]        |     276 | [32]         |\n",
       "| [\"chr21-13224428-SNV-0-1\"] |     552 | [220]        |     276 | [108]        |\n",
       "| [\"chr21-13224943-INS-0-1\"] |     552 | [547]        |     276 | [542]        |\n",
       "| [\"chr21-13229905-SNV-0-1\"] |     552 | [551]        |     276 | [550]        |\n",
       "| [\"chr21-13231128-SNV-0-1\"] |     552 | [407]        |     276 | [270]        |\n",
       "+----------------------------+---------+--------------+---------+--------------+\n",
       "\n",
       "+--------------+--------------+----------+----------------+----------------+\n",
       "| info.AC_Het  | info.AC_Hemi | info.MAF | info.HWE       | info.ExcHet    |\n",
       "+--------------+--------------+----------+----------------+----------------+\n",
       "| array<int32> | array<int32> |  float64 | array<float64> | array<float64> |\n",
       "+--------------+--------------+----------+----------------+----------------+\n",
       "| [212]        | [0]          | 4.42e-01 | [1.45e-21]     | [1.31e-21]     |\n",
       "| [112]        | [0]          | 3.99e-01 | [1.19e-02]     | [9.97e-01]     |\n",
       "| [5]          | [0]          | 9.06e-03 | [1.00e+00]     | [9.82e-01]     |\n",
       "| [1]          | [0]          | 1.81e-03 | [1.00e+00]     | [1.00e+00]     |\n",
       "| [137]        | [0]          | 2.63e-01 | [7.01e-07]     | [3.92e-07]     |\n",
       "+--------------+--------------+----------+----------------+----------------+\n",
       "\n",
       "+----------+----------+\n",
       "|   AF_AFR |   AF_EUR |\n",
       "+----------+----------+\n",
       "|  float64 |  float64 |\n",
       "+----------+----------+\n",
       "| 2.09e+00 | 1.41e+00 |\n",
       "| 2.68e+00 | 9.60e-01 |\n",
       "| 4.00e+00 | 3.89e+00 |\n",
       "| 4.00e+00 | 4.00e+00 |\n",
       "| 3.27e+00 | 2.77e+00 |\n",
       "+----------+----------+\n",
       "showing top 5 rows"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "mt=mt.annotate_rows(AF_AFR=hl.agg.filter(mt.population.super_population ==\"Africa\",\n",
    "                                     hl.agg.sum(mt.GT.n_alt_alleles())\n",
    "                                     / samplesPercohort[\"Africa\"]*2 ))\n",
    "mt=mt.annotate_rows(AF_EUR=hl.agg.filter(mt.population.super_population ==\"West Eurasia\",\n",
    "                                     hl.agg.sum(mt.GT.n_alt_alleles())\n",
    "                                     / samplesPercohort[\"West Eurasia\"]*2 ))\n",
    "mt.rows().show(5)"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "6858967c-7d14-4700-8b74-a9aa4ef70bb8",
   "metadata": {},
   "source": [
    "Now we calculated startified AF per cohort lets find the frequent variants in african samples"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 34,
   "id": "5d109ae3-5626-48d3-a14e-90bb9038d354",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/html": [
       "<table><thead><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"14\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td></tr><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"14\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">info</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td></tr><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">locus</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">alleles</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">rsid</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">qual</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">filters</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AF</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">UK</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AK</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">MA</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">ID</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AN</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AC</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">NS</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AC_Hom</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AC_Het</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AC_Hemi</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">MAF</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">HWE</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">ExcHet</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AF_AFR</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AF_EUR</div></td></tr><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">locus&lt;GRCh38&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;str&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">str</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">float64</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">set&lt;str&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;float64&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">int32</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">int32</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;str&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">int32</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">int32</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">float64</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;float64&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;float64&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">float64</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">float64</td></tr>\n",
       "</thead><tbody><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13224360</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;G&quot;,&quot;A&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13224360-SNV-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[4.42e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">31</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[31,0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13224360-SNV-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[244]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[32]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[212]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">4.42e-01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.45e-21]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.31e-21]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.09e+00</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1.41e+00</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13224428</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;C&quot;,&quot;T&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13224428-SNV-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[3.99e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">8</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[13,4]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13224428-SNV-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[220]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[108]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[112]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">3.99e-01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.19e-02]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[9.97e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.68e+00</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">9.60e-01</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13224943</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;C&quot;,&quot;CA&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13224943-INS-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[9.91e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">44</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[24,11]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13224943-INS-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[547]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[542]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[5]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">9.06e-03</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.00e+00]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[9.82e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">4.00e+00</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">3.89e+00</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13229905</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;A&quot;,&quot;G&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13229905-SNV-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[9.98e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">18</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[8,29]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13229905-SNV-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[551]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[550]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1.81e-03</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.00e+00]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.00e+00]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">4.00e+00</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">4.00e+00</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13231128</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;A&quot;,&quot;G&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13231128-SNV-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[7.37e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">60</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[31,0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13231128-SNV-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[407]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[270]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[137]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.63e-01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[7.01e-07]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[3.92e-07]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">3.27e+00</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.77e+00</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13231256</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;C&quot;,&quot;T&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13231256-SNV-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[5.80e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">55</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[24,31]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13231256-SNV-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[320]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[206]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[114]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">4.20e-01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.33e-02]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[9.96e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.14e+00</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.29e+00</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13231853</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;C&quot;,&quot;T&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13231853-SNV-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[5.89e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">10</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0,7]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13231853-SNV-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[325]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[228]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[97]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">4.11e-01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[6.47e-06]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.00e+00]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.27e+00</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.29e+00</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13231869</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;C&quot;,&quot;T&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13231869-SNV-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[5.89e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">10</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0,7]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13231869-SNV-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[325]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[228]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[97]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">4.11e-01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[6.47e-06]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.00e+00]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.27e+00</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.29e+00</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13231870</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;A&quot;,&quot;G&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13231870-SNV-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[5.89e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">10</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0,7]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13231870-SNV-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[325]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[228]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[97]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">4.11e-01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[6.47e-06]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[1.00e+00]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.27e+00</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.29e+00</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13232002</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;A&quot;,&quot;G&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13232002-SNV-0-1&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[7.19e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">62</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[31,31]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13232002-SNV-0-1&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[397]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[282]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[115]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.81e-01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[6.57e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[3.68e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">3.32e+00</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2.69e+00</td></tr>\n",
       "</tbody></table><p style=\"background: #fdd; padding: 0.4em;\">showing top 10 rows</p>\n"
      ],
      "text/plain": [
       "+----------------+------------+--------------------------+-----------+\n",
       "| locus          | alleles    | rsid                     |      qual |\n",
       "+----------------+------------+--------------------------+-----------+\n",
       "| locus<GRCh38>  | array<str> | str                      |   float64 |\n",
       "+----------------+------------+--------------------------+-----------+\n",
       "| chr21:13224360 | [\"G\",\"A\"]  | \"chr21-13224360-SNV-0-1\" | -1.00e+01 |\n",
       "| chr21:13224428 | [\"C\",\"T\"]  | \"chr21-13224428-SNV-0-1\" | -1.00e+01 |\n",
       "| chr21:13224943 | [\"C\",\"CA\"] | \"chr21-13224943-INS-0-1\" | -1.00e+01 |\n",
       "| chr21:13229905 | [\"A\",\"G\"]  | \"chr21-13229905-SNV-0-1\" | -1.00e+01 |\n",
       "| chr21:13231128 | [\"A\",\"G\"]  | \"chr21-13231128-SNV-0-1\" | -1.00e+01 |\n",
       "| chr21:13231256 | [\"C\",\"T\"]  | \"chr21-13231256-SNV-0-1\" | -1.00e+01 |\n",
       "| chr21:13231853 | [\"C\",\"T\"]  | \"chr21-13231853-SNV-0-1\" | -1.00e+01 |\n",
       "| chr21:13231869 | [\"C\",\"T\"]  | \"chr21-13231869-SNV-0-1\" | -1.00e+01 |\n",
       "| chr21:13231870 | [\"A\",\"G\"]  | \"chr21-13231870-SNV-0-1\" | -1.00e+01 |\n",
       "| chr21:13232002 | [\"A\",\"G\"]  | \"chr21-13232002-SNV-0-1\" | -1.00e+01 |\n",
       "+----------------+------------+--------------------------+-----------+\n",
       "\n",
       "+----------+----------------+---------+--------------+---------+\n",
       "| filters  | info.AF        | info.UK | info.AK      | info.MA |\n",
       "+----------+----------------+---------+--------------+---------+\n",
       "| set<str> | array<float64> |   int32 | array<int32> |   int32 |\n",
       "+----------+----------------+---------+--------------+---------+\n",
       "| {}       | [4.42e-01]     |      31 | [31,0]       |       0 |\n",
       "| {}       | [3.99e-01]     |       8 | [13,4]       |       0 |\n",
       "| {}       | [9.91e-01]     |      44 | [24,11]      |       0 |\n",
       "| {}       | [9.98e-01]     |      18 | [8,29]       |       0 |\n",
       "| {}       | [7.37e-01]     |      60 | [31,0]       |       0 |\n",
       "| {}       | [5.80e-01]     |      55 | [24,31]      |       0 |\n",
       "| {}       | [5.89e-01]     |      10 | [0,7]        |       0 |\n",
       "| {}       | [5.89e-01]     |      10 | [0,7]        |       0 |\n",
       "| {}       | [5.89e-01]     |      10 | [0,7]        |       0 |\n",
       "| {}       | [7.19e-01]     |      62 | [31,31]      |       0 |\n",
       "+----------+----------------+---------+--------------+---------+\n",
       "\n",
       "+----------------------------+---------+--------------+---------+--------------+\n",
       "| info.ID                    | info.AN | info.AC      | info.NS | info.AC_Hom  |\n",
       "+----------------------------+---------+--------------+---------+--------------+\n",
       "| array<str>                 |   int32 | array<int32> |   int32 | array<int32> |\n",
       "+----------------------------+---------+--------------+---------+--------------+\n",
       "| [\"chr21-13224360-SNV-0-1\"] |     552 | [244]        |     276 | [32]         |\n",
       "| [\"chr21-13224428-SNV-0-1\"] |     552 | [220]        |     276 | [108]        |\n",
       "| [\"chr21-13224943-INS-0-1\"] |     552 | [547]        |     276 | [542]        |\n",
       "| [\"chr21-13229905-SNV-0-1\"] |     552 | [551]        |     276 | [550]        |\n",
       "| [\"chr21-13231128-SNV-0-1\"] |     552 | [407]        |     276 | [270]        |\n",
       "| [\"chr21-13231256-SNV-0-1\"] |     552 | [320]        |     276 | [206]        |\n",
       "| [\"chr21-13231853-SNV-0-1\"] |     552 | [325]        |     276 | [228]        |\n",
       "| [\"chr21-13231869-SNV-0-1\"] |     552 | [325]        |     276 | [228]        |\n",
       "| [\"chr21-13231870-SNV-0-1\"] |     552 | [325]        |     276 | [228]        |\n",
       "| [\"chr21-13232002-SNV-0-1\"] |     552 | [397]        |     276 | [282]        |\n",
       "+----------------------------+---------+--------------+---------+--------------+\n",
       "\n",
       "+--------------+--------------+----------+----------------+----------------+\n",
       "| info.AC_Het  | info.AC_Hemi | info.MAF | info.HWE       | info.ExcHet    |\n",
       "+--------------+--------------+----------+----------------+----------------+\n",
       "| array<int32> | array<int32> |  float64 | array<float64> | array<float64> |\n",
       "+--------------+--------------+----------+----------------+----------------+\n",
       "| [212]        | [0]          | 4.42e-01 | [1.45e-21]     | [1.31e-21]     |\n",
       "| [112]        | [0]          | 3.99e-01 | [1.19e-02]     | [9.97e-01]     |\n",
       "| [5]          | [0]          | 9.06e-03 | [1.00e+00]     | [9.82e-01]     |\n",
       "| [1]          | [0]          | 1.81e-03 | [1.00e+00]     | [1.00e+00]     |\n",
       "| [137]        | [0]          | 2.63e-01 | [7.01e-07]     | [3.92e-07]     |\n",
       "| [114]        | [0]          | 4.20e-01 | [1.33e-02]     | [9.96e-01]     |\n",
       "| [97]         | [0]          | 4.11e-01 | [6.47e-06]     | [1.00e+00]     |\n",
       "| [97]         | [0]          | 4.11e-01 | [6.47e-06]     | [1.00e+00]     |\n",
       "| [97]         | [0]          | 4.11e-01 | [6.47e-06]     | [1.00e+00]     |\n",
       "| [115]        | [0]          | 2.81e-01 | [6.57e-01]     | [3.68e-01]     |\n",
       "+--------------+--------------+----------+----------------+----------------+\n",
       "\n",
       "+----------+----------+\n",
       "|   AF_AFR |   AF_EUR |\n",
       "+----------+----------+\n",
       "|  float64 |  float64 |\n",
       "+----------+----------+\n",
       "| 2.09e+00 | 1.41e+00 |\n",
       "| 2.68e+00 | 9.60e-01 |\n",
       "| 4.00e+00 | 3.89e+00 |\n",
       "| 4.00e+00 | 4.00e+00 |\n",
       "| 3.27e+00 | 2.77e+00 |\n",
       "| 2.14e+00 | 2.29e+00 |\n",
       "| 2.27e+00 | 2.29e+00 |\n",
       "| 2.27e+00 | 2.29e+00 |\n",
       "| 2.27e+00 | 2.29e+00 |\n",
       "| 3.32e+00 | 2.69e+00 |\n",
       "+----------+----------+\n",
       "showing top 10 rows"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "AFR_Frequent=mt.filter_rows(mt.AF_AFR > 0.7)\n",
    "AFR_Frequent.rows().show()"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "aa20deab-4068-46f8-bd6d-a30fa2b890d7",
   "metadata": {},
   "source": [
    "We can easily get the ids of the common variants"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 35,
   "id": "03bbd18b-9a52-4ae5-8c24-34814fa80364",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "[Stage 225:>                                                        (0 + 1) / 1]\r"
     ]
    },
    {
     "data": {
      "text/plain": [
       "['chr21-13224360-SNV-0-1',\n",
       " 'chr21-13224428-SNV-0-1',\n",
       " 'chr21-13224943-INS-0-1',\n",
       " 'chr21-13229905-SNV-0-1',\n",
       " 'chr21-13231128-SNV-0-1',\n",
       " 'chr21-13231256-SNV-0-1',\n",
       " 'chr21-13231853-SNV-0-1',\n",
       " 'chr21-13231869-SNV-0-1',\n",
       " 'chr21-13231870-SNV-0-1',\n",
       " 'chr21-13232002-SNV-0-1']"
      ]
     },
     "execution_count": 35,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "AFR_Frequent.rows().rsid.collect()[:10]"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "dd266a8d-4a02-4fb0-9db2-413381d0f75f",
   "metadata": {},
   "source": [
    "## Explore population genotypes of a specfic variant\n",
    "\n",
    "Let's explore the population data of a specific variant\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 36,
   "id": "df69ff9f-0f9b-4401-ad0c-0d6a6b58f999",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "[Stage 228:>                                                        (0 + 1) / 1]\r"
     ]
    },
    {
     "data": {
      "text/html": [
       "<table><thead><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"14\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td></tr><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"14\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">info</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td></tr><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">locus</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">alleles</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">rsid</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">qual</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">filters</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AF</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">UK</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AK</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">MA</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">ID</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AN</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AC</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">NS</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AC_Hom</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AC_Het</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AC_Hemi</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">MAF</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">HWE</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">ExcHet</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AF_AFR</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">AF_EUR</div></td></tr><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">locus&lt;GRCh38&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;str&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">str</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">float64</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">set&lt;str&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;float64&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">int32</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">int32</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;str&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">int32</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">int32</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;int32&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">float64</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;float64&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">array&lt;float64&gt;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">float64</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">float64</td></tr>\n",
       "</thead><tbody><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">chr21:13880084</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;A&quot;,&quot;ACAGCAAAACAAAAGGCACCTTGGCTCCTGTTTGCAGTAAGTTCCTCATTTTCATCTCACAGCCTCTCAATCTGATCCTTACTGTCTATTTTCCTGTGAGCCTTCTGATCACAAGTATTCAACAATTCTTTACAAAGATCCAAACTTACCCTCATCTCCCTGTCTTTGAAGTCCTCCAAACTCTCCAGAACTCCATCTGCTACCCCCTTCTGAACCTGCTTCTACATTATCAGCTATCTTTGTCATACCCTGGCAATGTGGTAAAGGAAGACAAGCCCATTTTCCGGGGAAAAATTCAAGGAGGTTTCAGATACTTGAATAAAAAGAAGCTGAGTGCTGATTGCCAAGACATTAGAGAGAAGGCCTTGAAGACATTTAATAGATCCACTTTGCAGTAATAATTTTCTCCATGATCATAAAGAAAAGAGGTTTAATAGGTTAATGATTCTGCAGGCTGTAAGGAAGCATAGTGGCTTCTGCATCTGACAGGACTCAGGAAGCCTCCCAATCATACCAGAACGTCAAGGGGCAAGGAGATGTCTCATTTGGCAGAAGTAGGAGCAAGACAGAGAAAGGAAACAGGTGTCATGCCCCATTACACAAGCAGATCTCATGAGAACTCACTATCACAAGGTCAGCATCTAGAAAATGGTGCTTAAACATTGGTGAAGGATCCGCCCCACACACCCAACTCCCACTGTTTCCAGGCAGAAGCCTCCTTCAGATGCAGAGCCTCTTGGAAAACCTCTATTATGGAAGTGCAGAAGGAAAATATGGGCTTGAAGTCCCCACACAGGTGGCCACCAACCTCCAGACCCCAGATTCATAGGCCCACCAACAACTCACGCCCTTAGTGTAGAAAAGCTACAGGCCCTCAATACCAGCCCACCCCACGAGAACAGCTGAGGGGCTAAAACCTGCAAAGCCACAGGTGCACTGCCCTAGTAGAGGTTTTCCACGAGGCTTTGCCTCTGCAGCAGGCTACTCCCCCTTCCTACTACCCCCCACCCTCCCACCACCCTACTGCCAACCCACTCCTCCCAATCCTACCCATCCCTTTTACCTTCCACCGCCACCAACCCCCTGTCCATAATTAAGTCACCTACTTCAACATTAGGGATTACAATTCCACATGAGTTTCATAGGGACACACAGGAAAACCATATAATTCTGACCCTGATATTCCAGAATCTCATGTCCTTATCACAGAGCAAAATACAGTCATGACCTCTCAAAAGTTTGCAAAAGTCTTAACTCATTCCAAATGTAAAAAATTCAGTCTCATCTGAGACAAGGCCACAGTCCCTTCTGTCTATGAGTCCCTGAATTTAAAACGGAGTTCTTTTCTTTCAAGGTACAATGATGGTAGAGACATTGTGTAAGCTTTCTCAGTCCAAAGGGAAGAAATTTCCCAGAAAAATAACACAAATGGGCCTACAGGCCCAATGCAAGTCCAAAACCCAGCGGGACAGTATTCACTCAGTCTCTCAGCTCCAAAATCATCAAGAGAATTCACTATCATGTGAACAGCATTAAGGAGAGCGTGTTTATCCATTTGTGAAACATCTGACCCCACCCTCATCTTTCACTCCCACCCACAAAAAAATCTCTTCTATTCTCCCCACTCCCTTACCTCCAACCCCCATGCTTCTCCATGATTAAATCGCCTCCCACCAGGCCCCATTTTTAACATTCCCCATTATAATTCCACATGATTTTGGTAGGGATGCAGAGCCAAATCATATTATTCTGACCCTGGCCCCCGTATCTCATGTTCTTCTCACACTGCAAAATACAATGATGCCTTCTCTACAGTTTCCCAATCTCTTAACTCATTCCAGCATTTACTGAAATGTCCAAAGCCCAAAGTCTCTTCTGAGACAAGGCTGCAGTCCCTTCTGCCCCTGAGCCTCTGAAATACAAAGCAAGTTAACTACTTCCAAGGTACAATGATTTTACAGGCATTGGGTAAGTATTCCCAGTCAAAAGGAAAAAATTTGTCAGAAAGAAGCACAAAACACAGTTGAGACTTACAAACACCATGCAAGTCAAAAACCCAGCAGGATAGTCATTGAATCTTACAGCTCCAAATCATTTTTTTTAAATCCAGATCCCACATCCAGAGCACTAGGGTATGAGGCCTGGGCTCCAAAGGCCTTGGGCAGCTCTGCACCTGTGGCTTTGCAAGGTCTAACCTCCACAGTGGCTCTCATGGGCTGGGCTAGTGTTGAGTACCTGCAGCTTTTCCACAATGAGGGTGCAAGCTGGTAGAGAGTCTATGAATCTGGCATTTGCAGAATGGTGTTACCCTGTATGGGAGTTCCAACCCTATATGTTCCTTCTGTACTGCCCTACTAAAGGAGGCTCTGCCTCTTGGAAAATTTTGACCTGGACACCCAGGTTTTTCCATATGTACTCTGGAGTCTAGAAAAAGGATCCCCAGCCTCCAGTTTTGTGCTCTGCGCACCTGCTGGCTTAACACTATGTGGAAGCCACCAAAGCCTGCAGCTTGTGCCCCTTGAAGCAGTGACCCAAGCTGTACATGTGCATCTTTCAGCCATGGCTGGAGCTGGAGCTTCAGGAATGCAGCCAGCAGTGTCCTGAGGATGGACACAAGAGTGGGGCCATGGTGCTGGAGAAGGAAACCATTCTTTTCTCCCAGGCCTCAGGGCCTGTGATAGCAAGGGCTGCTACAAAAGTCTCTGAAATGCCTTCATGGCCTTTTTAACACTGTATTGGCTATTAGCACTCAACTCCATTTTATGCAAATTTCTGAAGACTTCTTGAACTTTCTCACTGACAATCAGCTTTTCTTTTTGACCACTTGGCCAGGCTGCAAATTTTCCAAACTTTTAAATATGTTTCACCATGAGGTCATTTCTTTGGTCACATATAGGACCACAGGCTGTTCGACACAGACAGGACACCTCTTAAGCTTTGCTGCATAAAATTTCCTTCCAACAGATACAATCTAAATTATCACCCTGATGTTCAAAATTTCACAGGTCTCCAGGTTAAGGACATCGTGCCGCAACGTTCTTTGCTAAGGAAAAAACAAAAGTGACCTTGCCTCCTGTTCCCAGCAAGCTCCTCATTTTCATGTGAGACCTTCTAAGCCTGGTGATCACTGTCCATCCTTCTGTCACCTTTTTAATTACAACTATTTGACAAGTCTCTACACTGATCCAAACTTTTCCTCATCTTCCTGTCTTCTTCCAAGACCTCTAAACTCTCCAACCTCTGGCCATTACACACTTCTTAACCTGCTTCTACATTTTCAGCTACATGTGTCACAGCCTGGCAATGTGGTAAAAGAAGAAAAGTCCATTTCAGGAGAAAAATTAATGCAGGCTTCAGACATTTCCCTGAAAAGAAGCTGAGTGCTGATCACCAATACAACAAGGAAAAGGTCTTGAAGGCATTTCATAGCTCCACTTCACAGCACTAATTTTCTGTATAATCAGAAAGAAAAGAGGTTGAACTGGCTCATGGTTCTGCAAGCTTTAAATAAATCATAGAGGTTTCTGCTTCTGGGAGGACTCAGGAAGCCTCCCAATCATACCAGAAGACCAAGCAGCAATGGGATGTTTTATATGGCAGAAGTAGAAACAAGACAGAGAGAGGAAAAAGCTGCCACATGTTGTATAAACCTGTTATACAAGCAGATTTCCTGAGAACTCACTATCACAAGGTCAGCATCAAGAAGATGTTGCTTAACCACTGGTGAAAGATCTGCCCCCTACCACCCCTCCCCCCACTGTTTCCAGGCAGAAGCCTGAGGCAGAGGCAGAGCCACTAGGAAAACCTCTACTAGGGCAGTGCAGAAAAAATATATGGGCTTGTAGGCCCCACACAGGAGGTTACCATCCTCCAGACCCAAGATTCATAGACCCACCAGCAGCTTGCACTCTCAGTATGGAAAAGCCACAGGCACTCAACACCAGCCCAGCCCATGGGAGCAAACACGGGGGCTAAAGCCTGCAAAGCCACAGGTGCACTGCCCTGGTATAGAGGTTTTCCATGAGGCTCTGCCTCTGCAGCAGGCTACTCCCCCTTTCTACTGCCCACCACCCTCTCACCACCCTACTGCCAGCCTATTTCTCCCCACCCTACACACTTGTTTCTCTTCCACCCCTACCACTCTGCCGTTTGTGGTTAAATCACATCCCACTAGGCCCCACCTACAACAGTCAGGAATACAATTCCCCATGAGTTTTTGTAGGGAAACACAGCCAAACCATATTATTCTGATCCTGACACCCCCACATCTCATATCCTTCTCACACAGAAAAATACAAACAGGCCTTTTCAAGAGTTTCCAAAAGTCTTAACTCACTCCAGCAGTAACTCAAATGTAGTAAGTTCAAATCTCAACCAACAGAAGGCTGCAATCTCTTCTGCCTATGAGTCCCTGAATGTAAAAGACAATTCTTTTCTTTCAAGTTATAATGATGGCACAGGCACTGGGTAAGCTTTCTCAAACCAAAGGGAAGATTTTCCCAGAAAAAATAACACAATTGGTACACAGGCCCAATCCGAGTCCAAAACCCAGCAGGACAGCATTCATTTATCATGAGAACTCACTATCACACAGACTGCATTAAGGAGATAGTATTTAACCATTTGTGAAGGATCTGCCACCCATCCCCATGTTTTGCCCTCACCCATACCATGAACCCCCATTCTCCCACATCCCACATCCCCCTTCCAACCCCCATTCCCTACCATGATTAAATCACCTTCTACCAAGCCCCACATTTAACATTCCCCATTACAATTCCACATAAGTTTTGGTAGGGACACAGAGCCAAATCATATTATTCTTCCTTTGGCCCCCCCAATCTCATGTCCTTCTCATACTGCAAAATACAATGATGCATTCTCTACAGTCCCCCAATGTCTGAACTCATTCCAGCATTTACTCAAATGTCCATTTGTGAAGGATCCGCCCCCACCCCTGCCTTTCACCCCCAACCCCACCACAATCCCCCCAACCCTCACCACCCCCCAATCCCCCACCTCCCCACCACCACAATCCCCCCAACCCTCCCCGTCCCACAATCCCCTCAACCCTCCCCACCCTCCCAACCATCCAACCTCCACTCTCCACCAGGATTAAATCACCTTCCACCAGCCCCCACCTTTAACATTTCCCATTAAAATTCCACATGAGTTTTGGTAGAGACACAGAGCCAAAACATATTATTTTGTCCCTGGTCCCCCAAAGTTCATGTCTTTCTCACATTGCAAAATGCAATGATGCCTTCCCTAGAGTCCCCCAAGTCTTAACTCATCCCAACATTTACTCAAATATCCAAAGCCCAAAGTCTCTTCTGAGACAAGGCTGCCGGATCTTTTGCCCCGAGCCTCTGAAATACAAAGCAAGTTAACCACTTCCAAGGTGCAATGATTGTACAGGCTTTGGGTAAGCATTCCCAGCCAAAAAGAAGAAATTTGCCAGAAAGAAGCACAAAACACAGATGGGACTTAAAACTCCCTGCAAGTCAAAAACCCAGCAGGCCAGTCATTCCATCATACAGCTCCAAATCATCTTTTTGGAATCTATGTCCACATCCAGAGCACAGGGTGGTGTGACAGCTGGGATCCCAAGGCCTTGGGCAGCTCTGCACCTGTGGCATTGCAGAATCTTTCCCCTACAGCTGCCCTCATTGGCTAGGCTGGTGTTGAGTGCCTGTAGCTTTTCAACACTAAGGGTGCAAGCAGTTGGTGGGTCTATGAAACTGGGGCCTGGAAAATTGTGCCCCCCTGTATGGGGAATCCAACCCTATACTCTCCTTGTGTACTGCCCCAGTAGAGGTTTACCATGATGCTCTGCCTCTTGGAAAAGCTTCTGGTTGGACAATCAGGCTTTCTGATACATGCTCTGGAGTCTAGATGAAGGCTCAGAAGCTTCTAGACCTTGCTTTGTGCACCTGCTGGCTTAACACCATGTGGAGGCCACCAAGTCTATGAGCTTGCATCCTCTGAAGCAGTGATGCAAGCTGTACCTGTGCATCTTTCATCCATGGCTGGAGATGGAGATGGAGCTGCAGGGATGCAGGCAGCAGTGTCCTGAGGCTGCACACAGCAGTGGAGCCATGGGGCTGGCCCAGGAAACCATCCTTTTCTCCTAGGCCCCAGGGCCAGTGACAGCAAGGGCTGCTACAAAAGTCTCTGAAATGCCTTCAAGGCCTTTTTCCCATTATCTTGAATTATTAGCACTCGGCTCCTTTTTATGCAAATATCTGAAGCCTTCTTGACTTTCCCCCTGAAAATCAGCTTTTCTTTCTGACCACTTGTGGAGATTACAAATTTTCCATATGTTTAAGCTCTGCTTCTCATTTAAATATAAGTTCCAACTTATAGTCATTTCTTTGACCACACATAGGTGCACAGGGTGTTCAATGTAGGTAGGAGAACTCTTGAGCATTGTTGCTTAGAAGTTCATTCCACCAGATACACTCTAAATCATCACCCTCAAGTTCAGTTTCACAGATCTCCTGGGAAGGATCAATGTGTAGTCAATTACTTTGCTAAAGCAAAACAAAAAAACCTTGGCTCCTTTTCCCAGTAAGTCCTTCATTTTCACCTGACATCTTGTAAGCCTGGCCTTCACTGTCCATCCTTATGTTAGCCTTTTAATCACAACTATTTAACAAGTCTCTGCAATGGTCCAAACTTTCCCTCATCTTCCTGTCTTCTTCCAAGCTCTCCGAACTCTCTAACCTCTGGCCATTACCTAATTCAGAACCTGCTTCTACACTGTCAGCTATCTTTTTCGCAGCCTGGCAATGTGGTAAAAGAAGAAAAGACCATTATCAGGGGGAAACATCAAGAAGGTCTCCAATATCTGCATTGAAAAAAGCTCAGTGCTAATAGCCAAGAGATTGGGGGAAAGGCCTAGAAGTCATTTCATAGCTTCACTTCACAGCATTAATTTTCTGTATCTACATAAAGAAAAGAGACTTAGTTGACTCACAGTTCTTCAGGCTTTAAAGAAAGCACAGTGGTTTCTGCTTGTAGGAGGACTCAGGAAGCCTCCCAATCATACCAGAAGGCCAAGCGGCAATGAAATGTTTCATATGGCAGGAGAAGAAGCAAGACAGAGAGAGGAAAGAGGTGCAACATCCTCTTATACAACTAGATCTCATGAGAGCTCACTATCAGGAGATCAGCATCAAGAAGATGGTGCTTCACTGTTGGTGAAGGATTCGCCCACCACCCCATATCCACCACCCACTGTTTCCAAGCACAAGCCTGAGACAGAGGCAGATCCTCTTGGAAAACCTCTACTATGGCTGTTTAGAAGAAAACTATGGGCTTGGAGCCCCCATGGAGGATACCACCATCCTCCAGACCCCAGACCCATAGATCCATCAACAGCTCACACCCCATGTACGGAAAAGCTACAGGCACTCAACACCAGCCCAGCCCATGAGAGCAGCTACAGGTGCTAAACCCTGCAAAGCCCCAGGTGCACTGCCTTAGTAGAGTTTTTCCATGAGCCTCTGCCTCTGCGGCAGGCTACTCCCCTCCTGCTACACACCACCCTACAGCCAGCCTACTCCTCCCCACTTTACCCACCTGTTTTTACGTCCAATCCAACCCCTCTCCCATCCATGAATAAATCACCTCTCACAAGGCCCCACATGCAACATTCGGGATTACAATTACATGTGAGTTTAGGTAGGGACACACAGCTAAACCATATTATTCTGACCCTGATCCCCCGAATATCATATCCTTCTCACAGAGTAAAATACAATCAGGCCTTTTCAAAAGTTGTCGAAAGTCTTAAGTCATTGCAGCATTAAGTCAAATGTAAAAAGTTCAACGTCTCACCTGAGAAAAGGCTACAGTCCCTTTTGCCTATAAGTTCCTGAATTTAAAAGGGATTTATTTTCTTTCAAGGTACAAAGATGGTACAGGCATTGGGTAAGTTTTCTCAATCCAAAGGGGAGAGGTTTGCCAGGAAAATAACACAAATTGGATCACAGGGCCAATGCAAGTCCAAAACCCAGGAGACCACTATCCATTCAATCTCACAGCTCCAAAACCATCATGAGAACTCACCATCATGAAGAAAGAATTAAGGAGATGGTGTTTAACCGTTTGTGAAGGATCCTCCCCCACCCCCACTTTTCACCCCTCACCCCCACCATAATCCACCCATTCTCCCCAATCCCCACCTTCCAATACCCAGTGCCCTCCACGATTAAATCACCTTCTACCTGGCCCCACTTTTAACATTTCTGATTACAATTCCATATGAGTTTCCATAGGGACACACAGCCAAATCTTATTATTCTGTCCCTGCCCCACAAATCTCACGTCCTTCTCACTTTGCAAAATACAATGATGCCTTACTTACCATTCCCCAAGCTACTGTGCTTTTTTTTTACAGCCTGTAGAACCATGAGTCAATTAAACCTTTTTGTTATGATCATACAGAAAATTAGTATTGTGAAGTGAAGCTATGAAATGCCTTCAATGACTATTCCCCATCATCTTGGCTAAGACCCCCAAGGTCTTAACTCATTCTAGCATTTAGTCAAATGTCTGAAGCCCAAAGTCTCATCTGAGACAAAGATGCAGTCCCTTCTCCTCCTGAGCCTCTGAAATACAAAGCAAGTTAACTGCTTCCAAGGTATGATTGTCCAGACATTGAGTAAGAATTCCCAACCAAAAGGAAGATTTTTGCCAGAGAGAAGAACAAAACACAAACGAGACTTACAGGTCCCATGAAAATCCAAAACCCAGCAGGCCAGTTATTCAAACCTACAGCTCCAAAGTCATCCTTTTTCAATCCTTGTCCCATCTCCAGGGCACAAGGGTATGAGGGCTGGGTTCCCAAGGCCTTGGGCAGCTCTCTACCTGTGGCTTTGCAGTGTTCAGTCCCCACAGCTGCCCTCATGGGCTGTGCTGGTGTTGACTGACTGTAGTTTTTACCCACAGAGAGTACGAAGTTCTTGGTGGGTCTATGAATCTGGGGTCTGCATGATGCTGGCCTCCATTGTGGGGGCTACAAGCCCATATTTTCCTTCTGCACTGCCCTAATAGAGGTTTCCCAGGAGGCTCTGCTTTTTGGCTCCTTCTGTCTGGACTCCCAGGCATTTTCATATGTCTTCCGAAATCTATATGAAGGCTCCGAAGCCTCTGGGCTAGTGCTCTGTGCACTCGCGGGCTTAAAACTATATGGAAGCCATGAAGCCTTATAGCCTGTACCCTCTGAAGCAGTGATGCAATCTGTACCGGTGCATCTTTCAGCCAAGTTTGGAACAGGAGCTGGGGCTGCCAGGATGCAGGCAGCAGTGTCCTGAGGCTGCAAACAGCCGCAGGGTCATGGGGCTGGCCCAGGAAACCATTCTTCTCTCCTAGGTCCCAGGGCCTGTGACAGCAAGGGCTGCTGCAAACATCTCTGAAATGCCTCCAAGACTTTTTCCCCCATTGTCTTGGCTATTAGCATTGGCCTCCATTTTATGCAAGTTTCTGGAGCCTTCATGAATTTTCCCCCTGAAAATCAGCTTTTCTTTTTAACCACTTGGCCAGGCTGCGGATATTCCAAACTTTTGAGCTCTGCTTGTCATTTAAATATAAGTTCCAACTTGAGGTCATTTCCTCGGTCACACATAACCTCGGTCACACATGAAAGCACAGGCTGTTTGATGGAGACATGCCCCCACCCTTGTGCTATGCTGCCTAGAAATTTATTCCAACAGATATGCACTAAATCATCACCCTAGAGTTCAAAATTTCACAGATCTTGAGGGCAAGGTCGCCCTGCAGCCATGTTCTTTGCTACAGCAAAACAAAAGCTAACCTTGGCTCCCGTTCCCAGTAAGATCATCATTTTCATCTGAGACCTTGTAAGCCTGGCCTTCACTGTCCATCCTTCTGCCAGGCTTTTAATCACAACTATTTAACAAGTGCCTACAATGGTCCAAACTTTCCTTCATCTCTCTGTCTTCTTTCAAGATCTCCAAACTCTCCAACCTCTGGCTGTTACCCACTTCCGAACCTGCTTTACATTTTCAGCTATCTTTGTTGCAGCCTGGCAATGCAGAAGAAAAAGAAGTCCATTTTCAGGGGGAAACTTCAAGAAGCCTTCAGATATTTGCATTAAAAAGAAGTCCAGTGCTAATAGCCAAGACGATGGGGAAATGTCATTGAAGATATTTCATAGCTCCACTTCGAAGTACTTTATTTTCTGTATGATCATAACGAAAAGGGGTTTAATTGGCTCATGGTTCTGCAGGCTGTAAAGAAAGCATAGTGACTTCTGCTTCTGGGAGGACTCAGGAAGCCTCCCAATCATACCGGTAGGAAAACAGCAATGAAATGTTTCATACAGCAGGAGTAGGAGCAAGGCTGAGAGAGGAAAGTGGTGCCACACCATCCTGTAACCAGATCTCATGAGAACTCACTATCACTAGGTCAGCATCAAGAAGATGGTGCTTAACCATTGGTGAAGGATGCGCCCCCCAACACAGTTCCACCCCCTACCGTTCCAGACAGAAACCTGCTGCAGAGGCAGAGGCTCTTGGAAATCCTGTACTATGGCAGTGCAGAAGGAAAATAAGGGCTTTGAGTGACTATGCAGGAGGCCTCCAGCCTCTAGACCCCAGATTCATAGACATACCAACAGTTCACAACCTCAGTATGGAAAAGTGATAGGCACTCAACACCAGCCCAGCCCATGAGAGCAGCCATGGGGGCTGAAGCCTCCAAAGCCACAGGCGCACTGCCCTGGTAGAGGTTTTCCATGAGCCGCTGACTCTGCGGCAGGCTACTCCCCCTTCCTACTACCCACCACCCTCCCACCACCCTACAGCCAGCCTACTCTTCCCCACCCTACCCACCCCTTTTTTCTTCCACCCCTACCCCTCCCATGCATGATAAAATAATCTCACAGCAGGCCCCAACTCCAACATTTTGGATTACAATTCCACATGAGTTTTTCCAGGGGCACACAGCCAAATCATATTATGCTGACCTTGACCCCCCAAATCTCATATCCTTCTCACAGAATAAAATACAATCGTGTCTTTTCAAAGTTTCCAAAAGCCTTAACTCATTCCCGCATTAACTCAAATGTAAAAAGTTCAAAGTCTCATCTGAGACAAGGCTACAATCTCTTCTGCCTATGAGTCCCTGAAGTTAAAAGGGTGTTCGTTTCTTTCAAGGTACAATGATGGTACAGGTATTGGGTAAGCTTTCTCAATCCAAAGGGAAGAAATTTCCAAGAAAAATAACACAAATGGGACCACAGGCCCAATGGACATCCAAAATCCCGCAGGTCAGTGTTCATTCAGTCTCACAGCTCCAAAATCATGAAGAGAACTCACTATCAGAAGGACGGCATTAAGGAGATGGTGTTTAACAATTTGTGAAGGATGCACCCCCGCCCCTGCCTTACACCCCCAACCCCACCATAATCCCCTCCAACCCTCCTCACCACCCAATCCCCCCCAACCCTCCCCAACCCCCAGCCATCCAACCTGCACTCTCCGTCATGAATAAATCATCTTCCACCAGCCCCCACCTTTAACATTTCCCATTAACATTCCACAAGAGCTTTGGTAGAGACAGAGAGCCAAATCATATTACTCTGTCCCGGGTTGCCCAAAGTTCATGTCTTTCTCACATTGCAAAATGCAATGATGCCTTCCCTAGAGTCTCTCAAATCTTAACTCATTCCAGCATTTATTCAAGTGCCCAAAGCCCAGAGTCTTATCTGAGACAAGTCTACACTCCCTTCTGCCCATGAGCCACTGAATTATATATAAAGGAAGTTTACTACTTCCAAGGAGCAATCATTACACAGGTGTTGGGTAAGCATTCCCAGCCAAAAGGAAAAAAATTGCCAGAAAGAAGCTCAAAACACAGATGGGACTTACAGACCCCATGCAAGTCAAAAACCCAGCAGGCCAGTCATTGAATCCTACAGCTCCCAAATCATCTTTTGTGAATCTATACCCCACATCTGGAGCACAGGGGTGGATGGCTGTGCTCCCAAGACCTTCAGCAGCTCAGCATCTCTGGCTGTGCAGGGTATATCCCCCACAGGTGCCCTCATGGGCTGGGTTGGTGTTGAGTGCCTTTGACTTTTCCACACTGAGGGTGCCAGCAGTTGGTGCATCTATGAATCTGGGGTCTGGAAAATGGTGCATTCCTGTGTGGGGGCTGCAACCCTATATGTTCCTTCTGTACTGCCCTAGTAAATGTTTCCCATGAGGCTCTGCCTCTTGGAAAAGCTTCTGCCTCAACACCCAGGTTTTTCTGTATATACTCTGGAGTCTAGACAAAGGCTCCCAAGCCTCTAGTTCTGTGCTCTGTGCACCTGCTGGCTTAGTACTATGTGGAAGCCACCAAGGTTTGAAGCTTGCACCCCTGAAGCAGTGATGCAAGCTGTACCTGTGCATCTTTCAGCCGTGACTGGAGCTGGAGCTGGAGCTGGAGCTGCAGGGATGCAGACAGCAGTGTCCTGAGGACGGACACAGTAGCGCGACCATGGGACTCAATCAGGAAAGCATTCTTCGGTCCTAGACCTCAGGGCCTGTGACAGCAAGCTCTGCTGCAAAGGTCTCTGAAATGGCTTCAAGGCCTTTTAACCTTGTCTTAGCTATTAGCACTGGGCTCCATTTTATGCAAATTTCTGAAGGCTTCTTGAATTTTCCCACTGAAAATCAGCTTTGCTTTTTGACCACTTGGCCAGGCTGCAAATTTTCCAAACTTTTAAGCCCTGCTTCTCATTTAAATATAAGTTTCAATTTGAGGTCATTTATTCAGTCACAGAGAAGACCACAGGCTGTTCAAAACAGACAAGACACCTCTTGAGCTTTGCTGCCTACTTCATTTCACCAGATATACCCTAAATCATCACACTCAAGTTCAAAGTTTCAGAGGTCTCCAGGGCAGGGACACCATCCTGCCAAGTTCTTTGCTAAGGGAAAACAAAAGTAACCTTGACTCCTGTTCCCAGTAAGTTGCTCATTTTCATCTGAGACCTTCTAAGCCTGGTCTTCACTGTCCATCCTTCAGTCACTATTTTAATTATAGCTATGTAACAAGTCTCCATGGTCACCCTTTTAATTTAACACATCTCTACAATAGTCCAAATTTTCCCTCATCTTTCTTTCTTCTTCCAAGCCCCCCAAACTGTGCAGCGTCCGGTGGTTACCCACTTCTGAACCTGCTTCTACGTTTTCAGCCACCGTTGTGGCAGCCTAGCAATGTGGTGAAAGGAGAAAAGTCCATTTTCAGGGGGAAAATTCAAGAAGGCTTCAGATATTACCATATAAAAGTGGGCAAATGTTAATAGTAAAAAAAAAAAAAAATGGGGAAAAAACCTTGAGGGCATTTCATGGCTCCACTCTACAGTACAAATTTTCTGTAATATTATTTTTAAAAGAGTTTTAATTGGCTCATGGTTCTGCAGGTTGTAAAGGCAGCAAGTGGTTTCTGCTTCTGGGAGGACTCAGGGAGCCTCCCAATCATACCAAAAGGCCAAGTGACAATGAGATATTCCATATGGCAGGAGTAGGAAGAAGACACAGAGAAGGAAGAGGTGCCACACCAGTTTATACAACCAGATCTCATGAGAACTCACTATCAGGAGATCAGCATCAGGAAGATTAACCAATGGTGAAGGATCCACCCACACCACCGCCTACTGTTTCCAGGCAGAAGCCTCCTGCAGAGCAGAACCTCTTGGAGAACCTCTACGAGTGCAGTGCAGAAGGAAAATATGGGCTTGGAGCCCCCACACAGGAGGCCACCATCCTCCAGACTGCAGATACATAGACCCAACAGCTTGCACTCTCTGCGTGGAACAGCTACAGGCACTCCACACCAGCCCAGCCCATGAGAGCAGCCATGGGGGCTACACCCTGCAAAACCACAGGTGCACTGCCCTAGTAGAGACTTTCCCTGAGCCTCTGCCTCTGCAGCAGGCTACTCCCACTTCCTGCTACCCACCACCCTCTCACCACCCTACTAACAACCTACTCCTCACCCTACCCACCCCTTTTCCTTCCACCCCCGGCCCCCGACCATCCACGATTAAATCACCTCCAGCCAGGCCCCACCTCCAACATTAAAGATTACAATTCACTTGAGTTTTGTTAAAGAAACACAGCCAAATCATATTATTCTGACCCTGATCCCCACAGTCTCATGTGCTTCTCACAGAGAAAAATATATTCATGCCTTTTCAAAAGTTTCCAAAAGTCTTAAATCATTCCAACATTAACTCAAATATAAAAAAATCAACTTCTCATCTGAGACAGTTCTACAGTACGTTTTGCCTATGAGTCTCTGAATTTAAAAGGATGTTCTTTTCTTTCAAGGTACAATAATGGTACAGGCTTTGGGTAAGATTTTTCAATCCAGAGGGAAGAAATTTCCGAGGAAGGAAACACAAATGGGACCACAGGCCCAATACAAGTCCAAAACCCAGAAGGCCAGTATCCATTCAATCTTACAGCTCCAAAATCATGAAGAGAACTCACTATCACAAGGACAGCAATAAGGAGAATGTTTAATCATTTGTGAAGCATCCGCCCCACAACTCCCAATTTTCACTCCTCACCCGCACCATAAATCCCCCATTCTCCCTACGCCCCATCTTCCAACCCCAACTCTCCACCGTGATTAAATCACCTTCCACCAGGCCCCACCTTTAACATTCCGATGACAATTCCACATGAGTTTTGGTAGAGACACAGAGCTGAATTTTATTATTCTGTCCCTGGCTCCCCAAATCTCATGTCCTTCTCACATTGAAAAATATAATGATGCCTTCCCTACAATCCCCCAAAATCTTATATCATTACAGCATTTATTCAAATGTTGAAAGCTTAAAGTCTCATCTGGCACAAGGCTACAGTTGCTTAGGCCCATGAGCCTCTGAACTATAAAGCAAGTTAACTACTTCCAAGGTACAATGTTTGTAGAGCCATTGGGTAAGCATTCCCAGCCAAAAGAAAGAATTTTGCCAGAAAAAAAACAAAACATAGACAGGACTTACCGGTCCCATGAAACTCCAAAACCAAAAGGCCAGTCATTCAATCCTACAGCTCCAAAATCACCCTTTTTGAAACCCTGTCCCACATCCAGGGCACAGGGGTGTGAGGGCTGGGCTCCCAAGGCCTTGGGCAGCTTGGCACCTGTGGCTTTGCAGGGTTTATGCCCACGGCTGCCCTCAGGACCTCGGCTGGTGTTGAGTGCCTGTGACTTTTCCCCACTAAGGATACAAGTTGTTGGGGGTCTATGAATCTGGGGTCTGCATGATGGTGGCCTCCAGTGTGGAGGCTCCAACCCCATGTTTTCCTTCTGCACTGCCCTAGTAGAAGTTTCATATAAGGCTCTGCCTTTTTGGGATGTTTTTGCCTGGACACCCAGGCATTTCCATACATCTTCCAAAATCTATAGAGAGGTTTCCAAGCCTCTGGTCTCATGCTCCGTCCACCAATGGCTTAACACAATGAGGAAATTACCAAGGCTTCTAGCTGGCACCCTCTGTAGCAGTGACCCAAGCTGTAGCTGTGCATCTTTCAGTCATGGCTGGAGCTGGAGCTGGAGCTGGAGCTGGAGCTGCAGGGATGCAGGCAGCAGTGTCCTGAGGCTGCACACAGAGGGGGGGCATGGAACTGGCCCAGGAAACCATTCTTCTCTCCTAGGCCCCAGGGCCTGTAACAGCCAGGGCTGCTGCAAAGGTCTCTGAAATGCCTTCAAGGCCTTTTCCCTATTGTCTTGTCTATTAGCACTGGGCTCCTTTTCATGCGAGTTTCTGAAGCCTTCCTCAACTTTCCCCCTGAAAATCAGCTTTTCTTTTTGACCACATGGCCAGGCTGCAAATTTTCCAAACTTTTGAGTTCTGTTTCTCATGTAATGTGAGAGTTGGGACTCATTTAATGTAAGTCTCATCCAGAAGTCATTTCCTCCATCACACATAAGAACACAGGCTGTGTGATGCAGACAGGACACCTCTTGAGTTTGCTGCTCAGTTCATTCCACCAGATACTCAGTAAATCCTCACCCTCAAGTTCAAAATTTCACAGATCTCCAGGGCGAGGTCACCGTGCAGCCATGTTCTTTGCTAAGGAAACAAAAGTAACTTTGACTTCTGTTCCCAGTAAGAGCTTCATTTTCATCTGAGACCTTCTAAGTCGGGCTTTCACTAACCATTTTCCTGTGAGCCTTCTGATCACAAGTGTTTAGCAATTCTTTACAAAGATCCAAACTTTCTTTCATCTTCTTGTCTTTGAAGCCCTCCAAACTCTCCCGACCTCTGTCCGCTACTCCCTTCTGAATCTGCTTCTACATTATCACTATCTTTGCCACAGCCTGGCAATGTGGTAAAGGAAAACAAGTCCATTTTCAGGGGAAAATTCATGAAGCCTTCACATACTTGAATGAAAAGAAGCTGAGTGCTGATTGCCACGACAATGACATTTAATAGTTCCACTTTGCACTACTAATTTTCTCTATGATCATAAAGAAAAGAAGTTTAATTGGCTCATGATTCTGCAGACCATAAGGAAACATAATGGCTTCTGAATCTGGGAGGACTCAGGAAGCCTTCCAATCATACCAGAATGTCCAAGGGCAATGACATGATTCATGTGGCAGGAGTAGGCACAAGACACACACAGGAGAGAGGACCACACCCTATTATACAAACAGATCTCATGAGAACTCACTATCACAAGGTCAGCATCATGAAGATGGTGCTTAAACATTGAGGAAGGAACAACCACCCACCCCCAACTCCCACTGTTTCCAAACAGAAGCCTGCTGCAGAGGCAGAGCCTCTTGGAAAACCTCTACCAGGGAAGTGTGGAAGGAAAATATGGGCTTGAAGCCCCCAGGCAGATGGCCACCAACCTCCAGACACCAGATTCATAGACCCACCAACAGCTCACACCCTCTGTGGAAAAGCTACAGGCACTCAACAACAGCCCAGACCGTGAGAGCAGCTGCAGGGGCTAAACCCTGCAAAGCCACAGGTGCTCTGTCCTAGTAGAACTTTTCCATGAGGCTTTGCCTCTGCAGCAGGCTGCTCCCCCTTGCTACTACCCCCCACGCTCCCACCATTCTACTGCCAGCCTACTCCTCCCCACCCTAACCAACCCTTTTGTGATACCCTACCTTGTTTTAACCTGGTCGACTCTCCCTTAGCTGAGAGGGCCAGACAGACTCCATCTTGGCTCCTTCACTTGCAGCCCCTTACCCACCCCCCTTCCTCAAGGACTTAACTTGTGCAAGCTGACTCCCAGCACATCAAAGAATGCAATTACTGATAAGATACTCTGGCAAGCTATATCCACAGTTCCCAGGAATTCGCCCGGTTGATAGTACACAAAACCCCAGCATTTGTGTCCAGTTGATAGCACCCAAAGCCCCCACATCTATCACCTTTGGATGGATTTAAAGCCCCTGCACATGGAAATGTTTGTTTTCCTGTAGCCATTTATCTTTTTAACTTTTTTGCCTGTTTTGCTGCTGTGAGAGTCCTTCAGCGAGGCTCCCCCTCCCCTTTCTAAACCAAAGTATAAAAGAAAATCTAGCCCCTGCTTCCGGGCCAAGAGAATTTTGAGCACTAGCGGGCTCTCAGTTGCCGGCAATAAAGGTCTCCTGAAGTCGTCTCATGGTTTGGCGTTTCTCTACAACTCACTCGGTTACAACCCTTTTCCTTCCACCCCAACCTCCTCCAATCAATGACTAAATGATCTCCCCCAGGCCCCACCTTCAACATTTGGAATTACAATTGCACCTGAATTTTTATAGGGACACACAGCCAAACCATATTATTCTGATCCTGATATTCCAGAATCTCATGTCCTTAACACAGAGCAAAATACAATCATGCCTTTTCAAAACTTCCAACAGCCTTAACTCATTCCAAGTGTAAAAAGTTCAAAGTCTCATCTGAGACAAGGCTACTGTCCCTTCTGCCCATGGGTTCCTGAATTTAAAAGAGATTTCTTTTCTTTCAAGGTACAATGATGGTACAGGTGTTGTGTAAGCTTTCTCAATCCAAAGGGAAGAAATTTCCCAGAATACACAAACGGGACCGCAGGGCAAATGCAAGTCCAACACCCAGCAGGACACTATTCACTCAATCTCACAGCTCAAAAATCATCAAGAGAACTCACTGTCATGCGGACAGCATTAAGGAGATAGCGTTTACCCATTTGTGAAGAATCTTCCATCCCACCCTCATCTTTCACTCCCACCCACAAAATAATCTCTCCCATTCTCCCCACACCCCTACCTCCAACACCCACTCTTCTCCATGATTAAATCACCTCCCACCAGGTCCCACCTTTAACATTTCCCACTACAATTCCACATGAATATTGGTAGAGAGACAGAATCAAATCGTATTATTCTGACTCTTGCTCCCCAAATCTTGTATCCTTGTCACGCTGCAAAATACAATGATGACTTCTCTACTGTCCCCCAATGACTTAACTCATTCCAGCATTTACTGAAATGTCCAAGGACTTACAGACCCCATACAAGTCAAAAACCCAGCAGGCCAGTCATTGAATCCTACAGCTCCAAATCATTTTTTCTGAATGGATATCTCACATCCAGAGCACAGGTGTGTCATGGCTGGGCTCCCAAGGCCTTGGGCAGCTCTGCACCTGTGGCTGTGCAGGGTCTATCCCCCATAGCTGCCCTCATGGGCTGGGCTGGTGTTGAGTGCCTGTAGCTTTTCCACACCAAGGTTGGAAAAGCCAGCTGTTGGTGGGTCTATGAATCTGGGGTCTGGAGAATGGTGCCTCCATGTTTAGGGACTCCAGTCTTATATTCTCCTTCTGTACTGCCCTAGTAAAGGTTTCCCATGAGGCTCTGCCTCTTGGAAAAGCTTCTACCTGAAAACTCAGGTTTTTCTGTAGATACTCTGGAGTCTAGACAAAGGCTCCCAAGCCTCTAGTTTTGTTCTCTGTGCACCTGCTGGCTTAACACTATGTGGAAGCCACCAAAGCTTGAAGCTTACACCCCTGAAGCATGATGCAAGCTGTACCTGTGCATCTTTCAGCCATGGCTGGAACTAGAGCTGCAGGGATGCAGGCAGCAGTGTCTTGAGACTGCACATAGAGGGGGGTCATGGAACTGGCCTAGGAAACCATTCTTCTCTCCGAGGCCCCAGGGCCTATGATAGCAAGGGCTGCTGCAAAGGTTTCTGAAATGGCTTCAAGGCCTTTTCCCTATTGTCTTGGCTATTAGCACTGGGCTCCTTTTCATGAAAATTTCCGAAGCCTTCCTCAGTTTTCCCCTGAAAATCAGCTTTTCTTTTTGACCATTTGGCCAGGCTGCAAATTTTTGAGTTCTGTTTCTCATTTAATATAAGAGTTGGGACTCATTTAATGTAAGACCCATCCAGATGTCATTTCCTCGGTCACACATAAGGGCACGGGCTGTTCGATACAGACAGGACACCCCTTGAGCTTTGCTGTCCAGAAGTTTATTCCATCAGATACACAGTAAGTCATCACCCACAAGTTCAAAGTTTCACAGATCTCCAGGGCAGTGTCACTGTGCAGCCACGTTCTTTGCTACAGCAAAACAAAAGGCACCTTGGCTCCTGTTTGCAGTAAGTTCCTCATTTTCATCTGAGAGCTTCTCAATCTGATCCTTACTGTCTATTTTCCTGTGAGCCTTCTGATCACAAGTATTCAACAATTCTTTACAAAGATCCAAACTTACCCTCATCTCCCTGTCTTTGAAGTCCTCCAAACTCTCCAGAACTCCATCTGCTACCCCCTTCTGAACCTGCTTCTACATTATCAGCTATCTTTGTCATACCCTGGCAATGTGGTAAAGGAAGACAAGCCCATTTTCCGGGGAAAAATTCAAGGAGGTTTCAGATACTTGAATAAAAAGAAGCTGAGTGCTGATTGCCAAGACATTAGAGAGAAGGCCTTGAAGACATTTAATAGATCCACTTTGCAGTAATAATTTTCTCCATGATCATAAAGAAAAGAGGTTTAATAGGTTAATGATTCTGCAGGCTGTAAGGAAGCATAGTGGCTTCTGCATCTGACAGGACTCAGGAAGCCTCCCAATCATACCAGAACGTCAAGGGGCAAGGAGATGTCTCATTTGGCAGAAGTAGGAGCAAGACAGAGAAAGGAAACAGGTGTCATGCCCCATTACACAAGCAGATCTCATGAGAACTCACTATCACAAGGTCAGCATCTAGAAAATGGTGCTTAAACGTTGGTGAAGGATCCGCCCCACACACCCAACTCCCACTGTTTCCAGGCAGAAGCCTCCTTCAGATGCAGAGCCTCTTGGAAAACCTCTATTATGGAAGTGCAGAAGGAAAATATGGGCTTGAAGTCCCCACACAGGTGGCCACCAACCTCCAGACCCCAGATTCATAGGCCCACCAACAACTCACGCCCTTAGTGTAGAAAAGCTACAGGCCCTCAATACCAGCCCACCCCACGAGAACAGCTGAGGGGCTAAAACCTGCAAAGCCACAGGTGCACTGCCCTAGTAGAGGTTTTCCACGAGGCTTTGCCTCTGCAGCAGGCTACTCCCCCTTCCTACTACCCCCCACCCTCCCACTACCCTACTGCCAACCCACTCCTCCCAATCCTACCCATCCCTTTTACCTTCCACCGCCACCAACCCCCTGTCCATAATTAAGTCACCTACTTCAACATTAGGGATTACAATTCCACATGAGTTTCATAGGGACACACAGGAAAACCATATAATTCTGACCCTGATATTCCAGAATCTCATGTCCTTATCACAGAGCAAAATACCATCATGACCTCTCAAAAGTTTGCAAAAGTCTTAACTCATTCCAAATGTAAAAAATTCAGTCTCATCTGAGACAAGGCCACAGTCCCTTCTGTCTATGAGTCCCTGAATTTAAAACGGAGTTCTTTTCTTTCAAGGTACAATGATGGTAGAGACATTGTGTAAGCTTTCTCAGTCCAAAGGGAAGAAATTTCCCAGAAAAATAATACAAATGGGCCTACAGGCCCAATGCAAGTCCAAAACCCAGCGGGACAGTATTCACTCAGTCTCTCAGCTCCAAAATCATCAAGAGAACTCACTATCATGTGAACAGCATTAAGGAGAGCGTGTTTATCCATTTGTGAAACATCCGCCCCCCACCCTCATCTTTCACTCCCACCCACAAAAAAATCTCTTCTATTCTCCCCACTCCCTTACTTCCAACCCCCATGCTTCTCCATGATTAAATCGCCTCCCACCAGGCCCCATTTTTAACATTCCCCATTATAATTCCACATGATTTTGGTAGGGATGCAGAGCCAAATCATATTATTCTGACCCTGGCCCCCGTATCTCATGTTCTTCTCACACTGCAAAATACCATGATGCCTTCTCTACAGTTTCCCAATCTCTTAACTCATTCCAGCATTTACTGAAATGTCCAAAGCCCAAAGTCTCTTCTGAGACAAGGCTGGGGTCTCTTCTGCCCCTGAGCCTCTGAAATACAAAGTAAGTTAACTACTACCAAAGTACAGTGATTGTACACACATTGGGTAAGTATTCCCAGCCAAAAGGAAGAAATTAGCCAGAAAGAAGAACAAAACACAGATGGGACTTACAAACCCCATAGGAGTCAAAAATCCAACAGCCAGTCATTGAATCCTACAGTTCCAAACCATTTTTTTTGAATCCAGATCCCACATTCAGAGCACAAGGGTATGAGGCCTGGGCTCCCAAGGCCTTGGGCAGCTCTGCACCTGTGAAGTTGCAGGGTCTAACCTCCACAGTTGTCCTCATGGGCTGGGCTGATGTTGAATACCTATAGGTTTTCCACAATGAGGGTGCAAGCTGCTAGTAAGTCTATGAATCTGGTGTTTGCAGAATGGTGCCTCCCTGTATTGGGGTTCCAACCCTATATTTTCCTTCTGTACTGCCCTAGTAAAGGAGGCTCTGCCTCTTGGAAAAATTTCGACCTGGACACCCAACTTTTTCCATACATACTCTGGAGTCCAGACAAAGGATCCCCAGCCTCCAGTTTTGTGCTCTGAGCACCTGCTGGCTTAACACTATGTGGAAGCCACCAAGGCTTGCAGTTTGCACCCTCGGAAGCAGTGACCCAGGCTGTACCTGTGCATCTTTCAACCATGGCTGGAGCTGGAGCTTCAGGAATCCAGCCAGCAGTGTCCTGAGGATGGACATAGCAGCGGGGTCATGGGGCTGAAGAAGGAAACCATTCTTTTCTCCCAGGCCTCAGGGCCTGTGATAGCAAGGGCTGCTGAAAAAGTCTCTGAAATGCCTTCAAGGCCTTTTTAACATTGTATTGGCTATTAGCACTGAACTCCATTTTATAAACATTTCTGAAGCCTTCTTGAACTTTCCCACTGATAATAAGCTTTTCTTTTTGACCACTTGGCCAGGCTGCAAATTTTCACAACTTTTAAGCTCTCCTTGTCATTTAAATATGTTTCACCTTGAGGTCATTTCTTTGGTCACATATTTTCATGTGAGACCTTCTAAGCCTGGTGGTCACTGTCCATCCTTATGTCACCTTCTTAATTATAACTATTTAACAAGTCTCTACACTGATCCAAACTTTTCCTCATCTTCCTGTCTTCTTCCAAGACCTCCAAACTCTCCAACCTCTGGCCATTACACACTTCTTAACCTGCTTCTACATTTTCAGCTACATGTGTCACAGCCTGGCAATGTGGTAAAAGAAGAAAAGTCCATTTCAGGAGAAAAATTAATGCAGGCTTTAGACTTTTGCCTGAAAAGAAGCTGAGTGCTGATTGCCATGACAATAGGGAAAAGGTCTTGAAGGCATTTCATAGCTCCACTTTACAGCATTAATTTTCTGTATAATCAGAAAGAAAAGAGGTTGAACTGGCTCATGGTTCTGCAAGCTTTAAATAAATCATAGAGGCTTCTGCTTCTGGGAGGACTCAGGAAGCCTCCCAATCATACCAGAAGACCAAGCAACAATGGGAAGTTTTATATGGCAGAAGTAGAAACAAGACAGAGAGGAAAAAGGTGGCACACGTTGTATAAACCTGTTATACAACCAGATTTCCTGAGAACTCACTATCACAAGGTCAGCATCAAGAAGATGTTGCTTAACCATTGGTGAAAGATCTGCCCCCTACCACCCCCACCCCCCACTGTTTCCAGGCAGAAGCCTGAGGCACAGGCAGAGCCTCTTGGAAAACCTCTACTAGGGCAGTGCAGAAAAAATATATGGGCTTGGAGGCCCCACGCAACCATCCACCAGACCACAGATTCATAGACCCAACAATAGCTTGCATTCTCAGTATGGAAAAGCCACAGGCACTCAACACCAGCCCAGCCGACGAAGGCAGCCATGGGGGCTAATGCCTGCAAAGCCACAGGTGCACTGCCCTGGTAGAGCTTTTCCATGAGGCTCTGCCTCTGCAGCAGGCTACTCCCTCTTCCTACTGCCCACCACACTCTCACCACCCTACTGCCAGCCTACTCCTCCCCACCCTACCCACTTGTTTTCCCTTCCACCCCTACCAACCTCCCATTTGTGATTAAATCACTTCCCACCAGGCCCCACCTGCAACAGTCAGGAATACAATTCACCAAGAGTTTTTGTAGGGAAACACAGTCAAACCATATTATTCTGACCCTGAAACCCCCACATCTCATGTCCTTCTCACACAGAAAAATACAAACATGCCTTTTCAAAAGTTTCCAAAAGTCTTAACTCATTCCAGCAGTAACTCAAATGTAGTAAGTTCAAGTCTCATCCAAGACAAGGCTGCAATCTCTTCTGCCTATGAGTCCCTGAATGTAAAAGACAATTCTTTTCTTTCAAGTTACAATGATGGCACAGGCACTGGGTAAGCTTTCTCAATCCAAAGGGAAGATTTTCCCTGAAAAATAACACAACTGGGACACAGGCCCAATCCGAGTCCAAAACCCAGCAGGACAGCATTCATTTATCATGAGAACTCACTATCGCACAGACTGCATTAAGGTGATAGTATTTAACCATTTGTGAAGGATCTGCCACCCATCCCCATGTTTCACCCTCACCCACACCATGAACCCCCATTCTCCCACATCCACCTTCCAACCCCCATTCTCTACCATGATTAAATCACCTTCTACCAAGCCCCACATTTGACATTCCCCATTACAATTCCACATGAGTTTTGGAAGGGACACAGAGCCAAATCATATTATTCTCCCCTTGGTCCCCAACCTCATGACCTTCTTATACTGCAAAATATAATGATGTGTTCTCTAAGGTCCCCCAATGTCTGAACTCATTCCAGCATTTACTCAAATGTCCATTTGTGAAGGATCCACCCCCCACCCCTCCCTTTCAGCCACAAATGCACCACAATCCGCCAACACTCCCCACCCACCTATAGCCCCAACCCTCCACACCACCCCCAGCATCCACCCTCCATGCTCCACCATGATTAAATCACCTTCCACCAGCCCCCACCTTTAACATTTCCCATTAAAATTCCACATGAGTTTTGGTAGAGACACAGAGCCAAAACATATTATTCTGCCCCTGGTCCCCCAAATCTCATGTCTTTTTCATATTGCAAAATGCAATGATGCCTTCCCTAGAGTCCCCTAAATCTCAACTCATTCCAGCCTTTACTCAAATATCCAAAGCCCAAAGTCTCTTCTGAGACAAGGCTGCAGTCTCTTCTGCCCTGAGACTCTGAAATACACAGCAAATTAACTACTTCCAAGGTACAATGACTGTACTGGCATTGGTTAAGCATTCCCAGGCAAAAAGAAGAAATTTGCCAGAAAGAAGCATAAAACACAGATGGGACTTACAAACTCCCTGCAAGTCAAAAGCCCAGCAGACCAGTCATCCATCATACACCACCAAATCACCTTTTTGGAATCTATGTCCACATCCAGAGCACAGGGTGATGTGACAGCTGGGATCCCAAGGCCTTGGGCAGCTCTGCACCTGTGGCATTGCAGAATCTTTCCCCTACAGTTGCCCTCATTGACTAGGCTGGTGTTGAGTGCCTGTAGCTTTTCAACACTAAGGGTGCAAGCAGCTGGTGCGTCTATGAAACTGGGGCCTGGAAAATGGTGCCTCCCTGTATGGGGACTCCAACCCTATACTCTCCTTGTGTACTGCCTGAGTAGAAGTTTACGATGAGGCTCTGCCTCTTGGAAAAGCTTCTGGCTGGACAATCAGGCTTTCTGATACATCCTCTGAAGTCTAGATGAAGGCTCAGAAGCTTCTAGTCCTTGCTTTATGCAACTGCTGGCTTAACACCTTGTGGAAGCCACCAAGTCTTCGAGCTTGCATTCTCTGAAGCAGTGACACAAGCTGTACCTGTGCATCTTTCATCCATGGCTGGAGCTGGAGATGGAGCTGCAGGGATGCAGGCAGCAGTGTCCTGAGGCTGCACACAGCAGTGGAGCCATGGGGCTGGCCCAGGAAACCATCCTTTTCTCCTAGGCCCCAGGGCCAGTGACAGCAAGGGCTGCTACAAAAGTCTCTGAAATGCCTTCAAGGCCTTTTTCCCATTATCTTGAATTATTAGCACTCGGCTCCTTTTTATGCAAATATCTGAAGCCTTCTTGACTTTCCCCCTGAAAATCAGCTTTTCTTTCTGACCACTTGTGGAGATTACAAATTTTCCATATGTTTAAGCTCTGCTTCTCATTTAAATATAAGTTCCAACTTATAGTGATTTCTTTGACCACACATAGGTGCGCAGGCTGTTCAATGTAGGCAGGACAACTCTTGAGCATTGTTGCTTAGAAGTTCATTCTACCAGATACACTCTAAATCATCACCCTCAAGTTCAGTTTCACAGATCTCCTGGAAAGGATCAATGTGTAGTCAATTACTTTGCTAAGGCAAAACAAAAAAACCTTGGCTCCTCTTCCCAGTGAGTACTTCATTTTCACCTGAGATCTTGTAAGCCTGACATTCACTGTCCATCCTTATGTTAGCCTTTTAATCACAACTATTGAACAAGTCTCTGCAATGGTCCAAACTTTCCCTCATCTTCCTGTTTTCTTCCAAGATCTCCGAACTCTCTAACCTCTGGCCATTACCTAATTCAGAACCTGCTTCTACACTATCAGGTATCATTTTCGCAGCCTGGCAATGTGGTAACAGAAGAAAAGTCTATTATCAGGGGGAAACATCAAGATGGTATCCAATATTTGCATTGAAAAAAGCTCAGTGCTAATAACCAAGAGATTGGGGGAAGGCCTAGAAGTCATTTCATAGCTTCACTTCGCAGCATTAATTGTCTGTATGTACATAAAGAAAAGAGGTTTAGTTGACTCACAGTTCTTCAGGCTATAAAGAAAGCATAGTGGATTCTGCTTGTAGGAGGACTCAGGAAGCCTCCCAATCATACCAGAGGCCAAGCAGCAATGAAATGTTTCATATGCCAGAAGTAGAAGCAAGACAGAAAGAGGAAAGAGGTGCGACATCCTCTTATACAACTAGATCTCATGAGAGCTCACTGTCAGGAGATCAGCATCAAGAAGATGGTGCTTCACTGTTGGTGAAGGATCCGCCCACCACCCCATATCCACCACCCACTGTTTCCAAGTAGAAGCCTGAGACAGAGGCAGATCCTCTTGGAAAACCTCTACTATGGCTGTTTAGAAGAAAACTATGGGCTTGGAGCCCCCATGTAGGATACCAGCATCCTCCAATCCCCAGATTCATAGAACCATCAACAGCTCACACCCCCAGTATCGAAAAGCTACAGGCACTCAACACCAGCCCAGCCCATGAGAGCAGCTACAGGTGCTAAACCCTGCAAAGCCCCAGGTGCACTGCCTTAGTAGAGTTTTTCCATGAGCCTCTGCCTCTGCGGCAGGCTACTCCCATCCTGCTACACACCACCCTACAGCCAGCCTACTCCTCCCCACTTTACCCACCTGTTTTTACGTCCAATCCAACCCCTCTCCCATCCATGAATAAATCACCTCCCACCAGGCCTCACCTGCAACATTGGGGATTACAATTACATGTGAGTTTAGGTAGGGACACACAGCTAAACAATATTATTCTGACCCTGATCCCCCAAATATCATATCCTTCTCACAGAGTAAAATACAATCATGCCTTTTCAAAAGCTGCCAAAAGTCTTAAGTCATTTCAGCATTAACTCAAATTTAAAAAGTTCAAAGTCTCACCTGAGAAAAGGCTACAGACCCTTTGGCCTATAAGTTCCTGAATTTAAAAGGGATTTATTTTCTTTCAAGATACAAAGATGGTACAGGCATTGGGTAAGTTTTGTCAATCCAAAGGGGAGAGGTGTGCCAGGAAAATAACACAAATGGGATCACAGGGCCAATGCAAGTCCAAAACCCAGGAGGCCAGTATCCATTCAATCTCACTGCTCCAAAACAATCACAAGAACTCATCATCATGAGGAAAGGATTAAGGAGATGGTGTTTAACCATTTGTGAAGGATCCTACCCCCACCCCCACTTTTCACCCCTCACCCCCACCATAATCCACCCATTCTCCCCAATCCCCACCTTCCAATACCCAGTGCCCTCCACGATTAAATCACCTTCCACCTGGCCCCACTTTCAACATTTCTGATTACAATTCCATATGAGTTTCCATAGGGACACACAGCCAAATCTTATTATTCTGTCCCTGCCCCACAAATCTCATGTCCTTCTCACTTTGCAAAATACAATGATGCCTTACTTACCATTCCCCAAGCCACTGTGCTTTTTTTTTACAGCCTGCAGAACCATGAGCCCATTAAACCCCTTTTTGTTATGATCATACAGAAAATTAGTATTGTGAAGTGAAGCTATGAAATGCCTTCAATGACTTTTCCCCATCATCTCGGCTAAGACCCCCAAGGTCTTAACTCATTCCATCATTTACTCAACTGTCTGAAGCCCAAAGTCTCATCTAAGACAAAGATGCAGTCCCATCTCCTCCTGAGCCTCTGAAATACAAAGCAAGTTAACTACTTCCAAGGTATGATTGTCCAGACATTGAGTAAGAATTCCCAACCAAAAGGAAGATTTATGCCAGAGACAAGAACAAAACATAAACGGGACTTACAGGTCCCTTGAAAATCCAAAACCCAGCAGGCCAGTTATTCAAACCTACAGCTCCAAAGTCATCCTTTTTCAATCCTTGTCCCACATCCAGGGCACAAGTGTATGAGGGCTGGGTTCCCAAGGCCTTGGGCAGCACTCTACCTGTGGCTTTGCAGTGTTCAGTCCCCACAGCTGCCCTCATGGGCTGTGCTGGTGTTGAGTGCCTGTAGTTTTTACCCACAGAGGGTACAAAGTTCTTGGTGGGTCTATGAATCTGGGGTCTGCATGATGCTGGCATCCAGTGTGGGGGCCCCAACCCCATATTTTCCTTCTGCACTGCCCTAGTAGAGGTTTCCCAGGAGTCTCTGCTTTTTTGGCAGCCTTCTGTCTGGACACCAAGACACTTTCATACATCTTCCGAAATCTGTATGAAGGCTCCAAAGCCTCTGGGCTAGTGCTCTGTGCACTCGCTAGCTTAAAACTATATGGAAGCCATGAAGCCTTACAGCCTGTACCCTCTGAAGCAGTGATGCAATCTGTACCTGTGCATCTTTCAGCCAAGGTCGGTGCAGGAGCTGGGGCAGCCGGGTTTCAGGCAGCAGTGTCCTGAGGCTGCACACAGCAGCAGGGTCATGGGGCTGGCCCAGGAAACCATTCTTCTCTAATAGGCCCCAGGGACTGTGACAGCAAGGGCTGCTGCAAACATCTCTGAAATGCCTCCAAGGCTTTTTCCCCCAGTGTCTTGGCTATTAGCACTGGCCTCCATTTTATGCAAGTTTCTGGAGCCTTCATGAATTTTCCCCCGAAAATCAGCTTTTCTTTTTGACCACTTGGCCAGGCTGCGGATATTCCAAACTTTTGAGCTCTGCTTGTCATTTAAATATAAGTTCCAACTTGAGGTCATTTCCTCGGTCACACATAACCTCGGTCACACATGAAAGCACAGGCTGTTTGATGCAGACATGCCCCCACCCTTGTGCTATGCTGCCTAGAAGTTCTTTCCACCAGATATGCACTAAATCTTCACCCTAGAGTTCAAAATTTCACAGATCTTGAGGGCAAGGTCGCCCTGCAGCCATGTTCTTTGCTACAGCAAAACAAAAGCTAACCTTGGCTCCCGTTCCCAGTAAGATCCTCATTTTCATCTGAGACCTTGTAAGCCTGGCCTTCACTGTCCATCCTTCTGCCAGCCTTTTAATCACAACTATTTAACAAGTGCCTACAATGGTCCAAATTTCCCTTCATCTCCCTGCCTTCTTTCAAGATCTCCAAACTCTCCAACCTCTGGCTGTTACCCACTTCTGAACCTGCTTTACATTTTCAGCTATCTTTGTTGCAGCCTGGCAATGCAGAAGAAAAAGAAGTCCATTTTCAGGGGGAAAACTTCAGGAAGCCTTCAGATATTTGCATTAAAAAGAAGTCCAGTGCTAATAGCCAAGAAGATGGGGAAATGTCATTGAAGATATTTCATAGCTCCACTTCGCAGTACTTTATTTTCTGCATGATCATAACGAAAAGGGGTTTAATTGGCTCATGGTTCTGCAGGCTGTAAAGAAAGCATAGTGACTTCTGCTTCTGGGAGGACTCAGGAAGCCTCCCAATCATACCAGTAGGAAAACAGCAATGAAATGTTTCATACAGCAGGAGTAGGAGCAAGGCTGAGAGAGGAAAGTGGTGCCACACCGTCCTATAACCAGATCTCATGAGAACTCACTATCACTAGGTCAGCATCAAGAAGATGGTGCTTAAACATTGGTGAAGGATCCGCCCCCCAACACAGCTCCACCCCCTACCGTTCCAGACAGAAGCCTGCTGCAGAGGCAGAGGCTCTTGGAAATCCTGTACTGTGGCAGTGCAGAAGGAAAATAAGGGCTTTGAGTGACTATGCAGGAGGCCACCAGCCTCTAGACCCCAGATTCATAGACCTACCAACAGTTCACACCCTCAGTATGGAAAAGTGATAGGCACTCAACACCAGCCAAGCCTATGAGAGCAGGCTTGTGGGCTAAAGCCTGCAAAGCCACAGGCGCACTGCCCAGGTAGAGGTTTTCCAAGAGCCGCTGTCTCTGCAGCAGGCTACTCCCCCTTCCTACTACCCACCACCCTCCCACCACCCTACAGCCAGCCTACTCTTCCCCACCCTACCCACCCCTTTTTTCTTCCACCCCTACCCCTCCCATTCATGATTAAATAATCTCACACCAGACCCCAACTCCAACATTTTGGATTACAATTCCACATGAGTTTTTCCAGGGGCACACAGCCAAATCATATTATGCTGACCTTGACCCCACCAAATCTCATATCCTTCTCACAGAATAAAATAAAATCGTGTCTTTTCAAAGTTTCCAAAAGCCTTAACTCATTCCCACATTAACTCAAATGTAAAAAGCTCAAAGTCTCATCTGAGACAAGGTTACAATCTCTTCTGCCTATGAGTCCCTGAAGTTAAAAGGGTGTTCGTTTCTTTCAAGGTACAATGATGGTACAGATATTGGGTAACTTTTCTCAATCCAAAGGGAAGAAATTTCCAAGAACAATAACACAAATGGGACCACAGGCCCAATGGAAATCCAAAATCCCACAGGTCAGTGTTCAGTCAATCTCACAGCTCCAAAATCATGAAGAGAACTCAATATCAGAAGGACAGCATTAAGGAGATGGTGTTTAACCATTTGTGAAGGATGCACCCCCACCCCTGCCTTACACCCCCAACCCCACCACAATCCCCTCCAACCCTCCTCACCACCCAATCCCCCCCATCTCTCCCCAACCCTGAAACATCCAACCTCCTCTCTCCATCATGATTAAATCACCTTCCACCAGCCCCCACCTTTAACATTTCCCATTAACATTCCACATTAGCTTTGGTAGAGACAGAGAGCCAAAACATATTATTCTGTCCCTGGTCCCCCAGAGTTCATGTTTTTCTCACATTGCAAAATGTAATGATGCCTTCCTTAGAGTCTCTCAAATCTTAACCCATTCCAGCATTTACTCAAATGCCCAAAGCCGAGAGTCTTATTTGAGACAAGTCTACAGACCCTTCTGCCCATGAGCCACTGAATTATATATAAAGCAAGTTTACTACTTCCAAGGTGCAATGATTGTACAGGCGTTGGGTAAGCATTCCCAGCCAAAAGGAAAAAAATTGCCAGAAAGAAGCACAAAACACAGATGGGACTTACAGACCCCATGCAAGTCAAAAACCCAGCAAGCCAGTCATTGAATCCTACAGCTCCCAAATCATCTTTTCTGAATCTATACCTCACATCTGGGGCACAGGGGTGGATGGCTGGGCTCCCAAGGCCTTGGGCAGCTCAGCATCTGTGGCTGTGCAGTGTCTATCCCCGACAGGTGCCCTTATGGGCTGGGCTGGCGTTGAGTACCTGTGGCTTTTCCACACTGAGGGTGCGAGCAGTTGACGGGTCTATGAATCTGGGGTCTGGAAAGTGGTGCATTCCTGTGTGGGGGCTGCAACCCTATATGTTCCTTCTGTACTGCCCTAGTAAATGTTTCCCATGAGGCTCTGCCTCTTGGAAAAGCTTCTGCCTCAACACCCAGGTTTTTCTGTATATACTCTGGAGTCTAGACAAAGGCTCCCAAGCCTCTAGTTCTGTGCTCTGTGCACCTGCTGGCTTAGTACTATGTGGAAGCCACCAAGGTTTGAAGCTTGCACCCCTGAAGCAGTGATGCAAGCTGTACCTGTGCATCTTTCAGCCGTGACTGGAGCTGTAGCTGTAGCTGTAGCTGCAGGGATGCAGACAGCAGTGTCCTGAGGACGGACACAGTAGCGCGACCATGGGACTCAATCAGGAAAGCATTCTTCGGTCCTAGACCTCAGGGCCTGTGACAGCAAGCTCTGCTGCAAAGGTCTCTGAAATGGCTTCAAGACCTTTTAACCTTGTCTTAGCTATTAGCACTGGGCTCCATTTTATGCAAATTTCTGAAGCCTTCTTGAATTTTCCCACTGAAAATCAGCTTTGCTTTTTGACCACTTGGCCAGGCTGCAAATTTTCCAAACTTTTAAGCCCTGCTTCTCATTTAAATATAAGTTTCAATTTGAGGTCATTTATTCAGTCACAGAGAAGACCACAGGCTGTTCAAAACAGACAAGACACCTCTTGAGCTTTGCTGCCTACTTCATTTCACCAGATATACCCTAAATCATCACACTCAAGTTCAAAGTTTCAGAGGTCTCCAGGGCAGGGACACCATCCAGCCAAGTTCTTTGCTAAGGGAAAACAAAAGTAACCTTGACTCCTGTTCCCAGTAAGTTGCTCATTTTCATCTGAGACCTTCTAAGCCTGGTCTTCACTGTCCATCCTTCAGTCACTATTTTAATTATAGCTATGTAACAAGTCTCCATGGTCACCCTTTTAATTTAACACATCTCTACAATAGTCCAAATTTTCCCTCATCTTTCTTTCTTCTTCCAAGCCCCCCAAACTGTGCAACGTCCGGTGGTTACCCACTTCTGAACCTGCTTCTACGTTTTCAGCCACCGTTGTGGCAGCCTGGCAATGTGGTGAAAGGAGAAAAGTCCATTTTCAGGGGGAAAATTCAAGAAGGCTTCAGATATTACCATATAAAAGTGGGCAAATGTTAATAGTAAAAAAAAAAAAAAAATGGGGAAAAAACCTTGAGGGCATTTCATGGCTCCACTCTACAGTACAAATTTTCTGTAATATTATTTTTAAAAGAGTTTTAATTGGCTCATGGTTCTGCAGGTTGTAAAGGCAGCAAGTGGTTTCTGCTTCTGGGAGGACTCAGGGAGCCTCCCAATCATACCAAAAGGCCAAGTGACAATGAGATATTCCATATGGCAGGAGTAGGAAGAAGACACAGAGAAGGAAGAGGTGCCACACCAGTTTATACAACCAGATCTCATGAGAACTCACTATCAGGAGATCAGCATCAGGAAGATTAACCAATGGTGAAGGATCCACCCACACCACCGCCTACTGTTTCCAGGCAGAAGCCTCCTGCAGAGCAGAACCTCTTGGAGAACCTCTACGAGTGCAGTGCAGAAGGAAAATATGGGCTTGGAGCCCCCACACAGGAGGCCACCATCCTCCAGACTGCAGATACATAGACCCAACAGCTTGCACTCTCTGCGTGGAACAGCTACAGGCACTCCACACCAGCCCAGCCCATGAGAGCAGCCATGGGGGCTACACCCTGCAAAACCACAGGTGCACTGCCCTAGTAGAGACTTTCCATGAGCCTCTGCCTCTGCAGCAGGCTACTCCCCCTTCCTGCTACCCACCACCCTCTCACCACCCTACTAACAACATACTCCTCACCCTACCCACCCCTTTTCCTTCCACCCCCGGCCCCCGACCATCCACGATTAAATCACCTCCAGCCAGGCCCCACCTCCAACATTAAAGATTACAATTCACTTGAGTTTTGTTAAAGAAACACAGCCAAATCATATTATTCTGACCCTGATCCCCACAGTCTCATGTGCTTCTCACAGAGAAAAATATATTCATGCCTTTTCAAAAGTTTCCAAAAGTCTTAAATCATTCCAACATTAACTCAAATATAAAAAAATCAACTTCTCATCTGAGACAGTTCTACAGTACGTTTTGCCTATGAGTCTCTGAATTTAAAAGGATGTTCTTTTCTTTCAAGGTACAATAATGGTACAGGCTTTGGGTAAGATTTTTCAATCCAGAGGGAAGAAATTTCCGAGGAAGGAAACACAAATGGGACCACAGGCCCAATACAAGTCCAAAACCCAGAAGGCCAGTATCCATTCAATCTTACAGCTCCAAAATCATGAAGAGAACTCACTATCACAAGGACAGCAATAAGGAGAATGTTTAATCATTTGTGAAGCATCCGCCCCACAACTCCCAATTTTCACTCCTCACCCGCACCACAAATCCCCCATTCTCCCTACGCCCCATCTTCCAACCCCAACTCTCCACCGTGATTAAATCACCTTCCACCAGGCCCCACCTTTAACATTCTGATGACAATTCCACATGAGTTTTGGTAGAGACACAGAGCTGAATTTTATTATTCTGTCCCTGGCTCCCCAAATCTCATGTCCTTCTCACATTGAAAAATATAATGATGCCTTCCCTACAATCCCCCAAAATCTTATATCATTACAGCATTTATTCAAATGTTGAAAGCTTAAAGTCTCATCTGGCACAAGGCTACAGTTGCTTAGGCCCATGAGCCTCTGAACTATAAAGCAAGTTAACTACTTCCAAGGTACAATGTTTGTAGAGCCATTGGGTAAGCATTCCCAGCCAAAAGAAAGAATTTTGCCAGAAAAAACAAAACATAGACAGGACTTACCGGTCCCATGAAACTCCAAAACCAAAAGGCCAGTCATTCAATCCTACAGCTCCAAAATCACCCTTTTTGAAACCCTGTCCCACATCCAGGGCACAGGGGTGTGAGGGCTGGGCTCCCAAGGCCTTGGGCAGCGTGGCATCTGTGGCTTTGCAGGGTTTATGCCCACGGCTGCCCTCAGGACCTCGGCTGGTGTTGAGTGCCTGTGACTTTTCCCCACTAAGGATACAAGTTGTTGGGGGTCTATGAATCTGGGGTCTGCATGATGGTGGCCTCCAGTGTGGAGGCTCCAACCCCATGTTTTCCTTCTGCACTGCCCTAGTAGAAGTTTCATATAAGGCTCTGCCTTTTTGGGATGTTTTTGCCTGGACACCCAGGCATTTCCATACATCTTCCAAAATCTATAGAGAGGTTTCCAAGCCTCTGGTCTCATGCTCCGTCCACCAATGGCTTAACACAATGAGGAAATTACCAAGGCTTCTAGCTGGCACCCTCTGTAGCAGTGACCCAAGCTGTAGCTGTGCATCTTTCAGTCATGGCTGGAGCTGGAGCTGGAGCTGGAGCTGGAGCTGCAGGGATGCAGGCAGCAGTGTCCTGAGGCTGCACACAGAGGGGGGGCATGGAACTGGCCCAGGAAACCATTCTTCTCTCCTAGGCCCCAGGGCCTGTAACAGCCAGGGCTGCTGCAAAGGTCTCTGAAATGCCTTCAAGGCCTTTTCCCTATTGTCTTGTCTATTAGCACTGGGCTCCTTTTCATGCAAGTTTCTGAAGCCTTCCTCAACTTTCCCCCTGAAAATCAGCTTTTCTTTTTGACCACATGGCCAGGCTGCAAATTTTCCAAACTTTTGAGTTCTGTTTCTCATGTAATGTGAGAGTTGGGACTCATTTAATGTAAGTCTCATCCAGAAGTCATTTCCTCCATCACACATAAGAACACAGGCTGTGTGATGCAGACAGGACACCTCTTGAGTTTGCTGCTCAGTTCATTCCACCAGATACTCAGTAAATCATCACCCTCAAGTTCAAAATTTCACAGATCTCCAGGGCGAGGTCACCGTGCAGCCACGTTCTTTGCTAAGGAAACAAAAGTAACTTTGACTTCTGTTCCCAGTAAGAGCTTCATTTTCATCTGAGACCTTCTAAGTGGGGCTTTCACTAACCATTTTCCTGTGAGCCTTCTGATCACAAGTGTTTAGCAATTCTTTACAAAGATCCAAACTTTCTTTCATCTTCTTGTCTTTGAAGCCCTCCAAACTCTCCCGACCTCTGTCCGCTACTCCCTTCTGAATCTGCTTCTACATTATCACTATCTTTGCCACATCCTGGCAATGTGGTAAAGGAAAACAAGTCCATTTTCAGGGGAAAATTCATGAAGCCTTCACATACTTGAATGAAAAGAAGCTGAGTGCTGATTGCCACGACAATGACATTTAATAGTTCCACTTTGCACTACTAATTTTCTCTATGATCATAAAGAAAAGAGGTTTAATTGGCTCATGATTCTGCAGACCATAAGGAAACATAATGGCTTCTGAATCTGGGAGGACTCAGGAAGCCTTCCAATCATACCAGAATGTCCAGGGGCAATGACATGATTCATGTGGCAGGAGTAGACACAAGACACACACAGGAGAGAGGGCCACACCCTATTATACAAACAGATCTCATGAGAACTCACTATCACAAGGTCAGCATCATGAAGATGGTGCTTAAACATTGAGGAAGGAACAACCACCCACCCCCAACTCCCACTGTTTCCAAACAGAAGCCTGCTGCAGAGGCAGAGCCTCTTGGAAAACCTCTACCAGGGAAGTGTGGAAGGAAAATATGGGCTTGAAGCCCCCATGCAGATGGCCACCAACCTCCAGACCCCAGATTCATAGACCCACCAAGAGCTCACACCCTCTGTGGAAAAGCTACAGGCACTCAACAACAGCCCAGACCGTGAGAGCAGCTGCAGGGGCTAAACCCTGCAAAGCCACAGGTGCTCTGTCCTAGTAGAACTTTTCCATGAGGCTTTGCCTCTGCAGCAGGCTGCTCCCCCTTGCTACTACCCCCCACGCTCCCACCATTCTACTGCCAGCCTACTCCTCCCCACCCTAACCAACCCTTTTGTGATACCCTACCTTGTTTTAACCTGGTCGACTCTCCCTTAGCTGAGAGGGCCAGACAGACTCCATCTTGGCTCCTTCACTTGCAGCCCCTTACCCACCCCCCTTCCTCAAGGACTTAACTTGTGCAAGCTGACTCCCAGCACATCAAAGAATGCAATTACTGATAAGATACTCTGGCAAGCTATATCCACAGTTCCCAGGAATTCGCCCGGTTGATAGTACACAAAACCCCAGCATTTGTGTCCAGTTGATAGCACCCAAAGCCCCCACATCTATCACCTTTGGATGGATTTAAAGCCCCTGCACATGGAAATGTTTGTTTTCCTGTAGCCATTTATCTTTTTAACTTTTTTGCCTGTTTTGCTGCTGTGAGAGTCCTTCAGCGAGGCTCCCCCTCCCCTTTCTAAACCAAAGTATAAAAGAAAATCTAGCCCCTTCTTCCAGGCCAAGAGAATTTTGAGCACTAGCGGGCTCTCAGTTGCCGGCAATAAAGGTCTCCTGAAGTCGTCTCATGGTTTGGCGTTTCTCTACAACTCACTCGGTTACAACCCTTTTCCTTCCACCCCAACCTCCTCCAATCAATGACTAAATGATCTCCCCCAGGCCCCACCTTCAACATTTGGAATTACAATTGCACCTGAATTTTTATAGGGACACACAGCCAAACCATATTATTCTGACCCTGATATTCCAGAATCTCATGTCCTTAACACAGAGCAAAATACAATCATGCCTTTTCAAAACTTCCAACAGCCTTAACTCATTCCAAGTGTAAAAAGTTCAAAGTCTCATCTGAGACAAGGCTACTGTCCCTTCTGCCCATGGGTTCCTGAATTTAAAAGAGATTTCTTTTCTTTCAAGGTACAATGATGGTACAGGTGTTGTGTAAGCTTTCTCAATCCAAAGGGAAGAAATTTCCCAGAATACACAAACGGGACCGCAGGGCAAATGCAAGTCCAACACCCAGCAGGACACTATTCACTCAATCTCACAGCTCAAAAATCATCAAGAGAACTCACTATCATGCGGACAGCATTAAGGAGATAGCGTTTACCCATTTGTGAAGAATCTTCCATCCCACCCTCATCTTTCACTCCCACCCACAAAATAATCTCTCCCATTCTCCCCACACCCCTACCTCCAACATCCACTCTTCTCCATGATTAAATCACCTCCCACCAGGTCCCACCTTTAACATTCCCCACGACAATTCCACATGAATATTGGTAGAGAGACAGAATCAAATCGTATTATTCTGACTCTTGCTCCCCAAATCTTGTATCCTTGTCACGCTGCAAAATACAATGATGACTTCTCTACTGTCCCCCAATGACTTAACTCATTCCAGCATTTACTGAAATGTCCAAGGACTTACAGACCCCATACAAGTCAAAAACCCAGCAGGCCAGTCATTGAATCCTACAGCTCCAAATCATTTTTTCTGAATGGATATCTCACATCCAGAGCACAGGTGTGTCATGGCTGGGCTCCCAAGGCCTTGGGCAGCTCTGCACCTGTGGCTGTGCATGGTCTATCCCCCACAGCTGCCCTCATGGGCTGGGCTGGTGTTGAGTGCCTGTAGCTTTTCCAAACTAAGGTTGGAAAAGCCAGCTGTTGGTGGGTCTATGAATCTGGGGTCTGGAGAATGGTGCCTCCATGTTTAGGGACTCCAGTCTTATACTCTCCTTCTGTACTGCCCTAGTAAAGGTTTCCCATGAGGCTTTGCCTCTTGGAAAAGCTTCTACCTGAAAACCCAGGTTTTTCCGTAGATACTCTGGAGTCTAGACAAAGGCTCCCAAGCCTCTAGTTTTGTTCTCTGTGCACCTGCTGGCTTAACACTATGTGGAAGCCACCAAGGCTTGAAGCTTACACCCCTGAAGCATGATGCAAGCTGTACCTGTGCATCTTTCAGCCATGGCTGGAACTAGAGCTGCAGGGATGCAGGCAGCAGTGTCTTGAGACTGCACATAGAGGGGGGTCATGGAACTGGCCTAGGAAACCATTCTTCTCTCCGAGGCCCCAGGGCCTATGATAGCAAGGGCTGCTGCAAAGGTTTCTGAAATGGCTTCAAGGCCTTTTCCCTATTGTCTTGGCTATTAGCACTGGGTTCCTTTTCATGCAAATTTCCGAAGCCTTCCTCAGTTTTCCCCTGAAAATCAGATTTTCTTTTTGACCATTTGGCCAGGCTGCACATTTTTGAGTTCTGTTTCTCATTTAATATAAGAGTTGGGACTCATTTAATGTAAGACCCATACAGATGTCATTTCCTCGGTCACACATAAGGGCACGGGCTGTTCGATACAGACAGGACACCCCTTGAGCTTTGCTGCCCAGAAGTTTATTCCATCAGATACACAGTAAGTCATCACCCACAAGTTCAAAGTTTCACAGATCTCCAGGGCAGTGTCACTGTGCAGCCACGTTCTTTGCTC&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;chr21-13880084-INS-1-38892&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">-1.00e+01</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">{}</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[3.99e-02]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">301</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0,301]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[&quot;chr21-13880084-INS-1-38892&quot;]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">552</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[22]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">276</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[2]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[20]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[0]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">3.99e-02</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[3.53e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">[9.40e-01]</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">0.00e+00</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">5.60e-01</td></tr>\n",
       "</tbody></table>"
      ],
      "text/plain": [
       "+----------------+\n",
       "| locus          |\n",
       "+----------------+\n",
       "| locus<GRCh38>  |\n",
       "+----------------+\n",
       "| chr21:13880084 |\n",
       "+----------------+\n",
       "\n",
       "+------------------------------------------------------------------------------+\n",
       "| alleles                                                                      |\n",
       "+------------------------------------------------------------------------------+\n",
       "| array<str>                                                                   |\n",
       "+------------------------------------------------------------------------------+\n",
       "| [\"A\",\"ACAGCAAAACAAAAGGCACCTTGGCTCCTGTTTGCAGTAAGTTCCTCATTTTCATCTCACAGCCTCT... |\n",
       "+------------------------------------------------------------------------------+\n",
       "\n",
       "+------------------------------+-----------+----------+----------------+\n",
       "| rsid                         |      qual | filters  | info.AF        |\n",
       "+------------------------------+-----------+----------+----------------+\n",
       "| str                          |   float64 | set<str> | array<float64> |\n",
       "+------------------------------+-----------+----------+----------------+\n",
       "| \"chr21-13880084-INS-1-38892\" | -1.00e+01 | {}       | [3.99e-02]     |\n",
       "+------------------------------+-----------+----------+----------------+\n",
       "\n",
       "+---------+--------------+---------+--------------------------------+---------+\n",
       "| info.UK | info.AK      | info.MA | info.ID                        | info.AN |\n",
       "+---------+--------------+---------+--------------------------------+---------+\n",
       "|   int32 | array<int32> |   int32 | array<str>                     |   int32 |\n",
       "+---------+--------------+---------+--------------------------------+---------+\n",
       "|     301 | [0,301]      |       0 | [\"chr21-13880084-INS-1-38892\"] |     552 |\n",
       "+---------+--------------+---------+--------------------------------+---------+\n",
       "\n",
       "+--------------+---------+--------------+--------------+--------------+\n",
       "| info.AC      | info.NS | info.AC_Hom  | info.AC_Het  | info.AC_Hemi |\n",
       "+--------------+---------+--------------+--------------+--------------+\n",
       "| array<int32> |   int32 | array<int32> | array<int32> | array<int32> |\n",
       "+--------------+---------+--------------+--------------+--------------+\n",
       "| [22]         |     276 | [2]          | [20]         | [0]          |\n",
       "+--------------+---------+--------------+--------------+--------------+\n",
       "\n",
       "+----------+----------------+----------------+----------+----------+\n",
       "| info.MAF | info.HWE       | info.ExcHet    |   AF_AFR |   AF_EUR |\n",
       "+----------+----------------+----------------+----------+----------+\n",
       "|  float64 | array<float64> | array<float64> |  float64 |  float64 |\n",
       "+----------+----------------+----------------+----------+----------+\n",
       "| 3.99e-02 | [3.53e-01]     | [9.40e-01]     | 0.00e+00 | 5.60e-01 |\n",
       "+----------+----------------+----------------+----------+----------+"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "SV=mt.filter_rows(mt.rsid==\"chr21-13880084-INS-1-38892\")\n",
    "SV.rows().show()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 38,
   "id": "cfa4cd92-2b37-491b-8cb3-763c452a6009",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "[Stage 234:>                                                        (0 + 1) / 1]\r"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "AFR Freq =0.00\n"
     ]
    },
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "[Stage 236:>                                                        (0 + 1) / 1]\r"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "West Eurasia Freq =0.56\n"
     ]
    }
   ],
   "source": [
    "print(\"AFR Freq =%.2f\"% SV.rows().AF_AFR.collect()[0])\n",
    "print(\"West Eurasia Freq =%.2f\"% SV.rows().AF_EUR.collect()[0])"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "6d3816ff-bdc6-49f1-9ac3-fd7a7e00f70f",
   "metadata": {},
   "source": [
    "### Here we are showing the sum of alleles found per each population.\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 39,
   "id": "de201625-b8f8-40fc-906c-b6bbebaad7de",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "2023-03-27 12:01:46.715 Hail: INFO: Ordering unsorted dataset with network shuffle\n",
      "2023-03-27 12:01:49.021 Hail: INFO: Ordering unsorted dataset with network shuffle\n"
     ]
    },
    {
     "data": {
      "text/html": [
       "<table><thead><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;\"></div></td></tr><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">breed</div></td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \" colspan=\"1\"><div style=\"text-align: left;border-bottom: solid 2px #000; padding-bottom: 5px\">alleleCount</div></td></tr><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">str</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; text-align: left;\">int64</td></tr>\n",
       "</thead><tbody><tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;Armenian in Armenia (SGDP)&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;Bedouin B in Israel(Negev) (SGDP)&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;Jordanian in Jordan (SGDP)&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;Turkish in Turkey (SGDP)&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;Yemenite Jew in Yemen (SGDP)&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">2</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;Basque in France (SGDP)&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;Bergamo in Italy(Bergamo) (SGDP)&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;Estonian in Estonia (SGDP)&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;Georgian in Georgia (SGDP)&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1</td></tr>\n",
       "<tr><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">&quot;Greek in Greece (SGDP)&quot;</td><td style=\"white-space: nowrap; max-width: 500px; overflow: hidden; text-overflow: ellipsis; \">1</td></tr>\n",
       "</tbody></table><p style=\"background: #fdd; padding: 0.4em;\">showing top 10 rows</p>\n"
      ],
      "text/plain": [
       "+-------------------------------------+-------------+\n",
       "| breed                               | alleleCount |\n",
       "+-------------------------------------+-------------+\n",
       "| str                                 |       int64 |\n",
       "+-------------------------------------+-------------+\n",
       "| \"Armenian in Armenia (SGDP)\"        |           2 |\n",
       "| \"Bedouin B in Israel(Negev) (SGDP)\" |           2 |\n",
       "| \"Jordanian in Jordan (SGDP)\"        |           2 |\n",
       "| \"Turkish in Turkey (SGDP)\"          |           2 |\n",
       "| \"Yemenite Jew in Yemen (SGDP)\"      |           2 |\n",
       "| \"Basque in France (SGDP)\"           |           1 |\n",
       "| \"Bergamo in Italy(Bergamo) (SGDP)\"  |           1 |\n",
       "| \"Estonian in Estonia (SGDP)\"        |           1 |\n",
       "| \"Georgian in Georgia (SGDP)\"        |           1 |\n",
       "| \"Greek in Greece (SGDP)\"            |           1 |\n",
       "+-------------------------------------+-------------+\n",
       "showing top 10 rows"
      ]
     },
     "metadata": {},
     "output_type": "display_data"
    }
   ],
   "source": [
    "entries = SV.entries()\n",
    "results = (entries.group_by(breed = entries.population.population)\n",
    "      .aggregate(alleleCount = hl.agg.sum(entries.GT.n_alt_alleles())))\n",
    "results=results.order_by(-results.alleleCount)\n",
    "results.show()"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "0fd6113d-e0d8-4d1e-883d-d325d612f1d0",
   "metadata": {},
   "source": [
    "Finally get the ids of the samples that have this variant"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 40,
   "id": "c2de6251-cb32-4ff5-b238-fff2a85f0787",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "[Stage 247:>                                                        (0 + 1) / 1]\r"
     ]
    },
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "['Armenian222', 'Est375', 'HG01504', 'HG02494', 'HGDP00616', 'HGDP00650', 'HGDP00722', 'HGDP01172', 'HGDP01364', 'Jordan603', 'Kayseri23827', 'Kayseri24424', 'NA17374', 'NorthOssetia5', 'Sam02', 'YemeniteJew4695', 'YemeniteJew5433', 'armenia293', 'iran11', 'mg27', 'tdj409_shugnan']\n"
     ]
    }
   ],
   "source": [
    "results = entries.filter(entries.GT.is_non_ref())\n",
    "print(results.s.collect())"
   ]
  },
  {
   "cell_type": "markdown",
   "id": "c6244dc9-b27b-4939-99b4-ca2f998ffe8e",
   "metadata": {},
   "source": [
    "# Run principal component analysis (PCA) on the Hardy-Weinberg-normalized genotype call matrix.\n",
    "Finally lets run pca on the genotypes and visualize how the samples are related to each others"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 22,
   "id": "37af96cf-b623-486e-96f8-ca0128bfe09d",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "2023-03-27 11:49:16.724 Hail: INFO: hwe_normalize: found 62021 variants after filtering out monomorphic sites.\n",
      "2023-03-27 11:49:17.248 Hail: INFO: Coerced sorted dataset\n",
      "2023-03-27 11:49:19.919 Hail: INFO: pca: running PCA with 10 components...) / 1]\n",
      "2023-03-27 11:49:30.292 Hail: INFO: wrote table with 0 rows in 0 partitions to /tmp/persist_tableUATPGblIIQ\n",
      "    Total size: 23.71 KiB\n",
      "    * Rows: 0.00 B\n",
      "    * Globals: 23.71 KiB\n",
      "    * Smallest partition: N/A\n",
      "    * Largest partition:  N/A\n"
     ]
    }
   ],
   "source": [
    "eigenvalues, pcs, _ = hl.hwe_normalized_pca(mt.GT)\n",
    "mt = mt.annotate_cols(scores = pcs[mt.s].scores)\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 27,
   "id": "7c7a5750-e021-4d12-a015-2c952727f093",
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   "outputs": [
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       "\n",
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       "\n",
       "\n",
       "\n",
       "\n",
       "  <div class=\"bk-root\" id=\"864cbb7d-5f1b-4faf-a521-dd0ec4381084\" data-root-id=\"3014\"></div>\n"
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Iran (SGDP)\",\"Brahui in Pakistan (SGDP)\",\"Brahui in Pakistan (SGDP)\",\"Bulgarian in Bulgaria (SGDP)\",\"Samaritan in Israel (SGDP)\",\"Finnish in Finland (SGDP)\",\"Georgian in Georgia (SGDP)\",\"Basque in France (SGDP)\",\"Spanish in Spain (SGDP)\",\"Jordanian in Jordan (SGDP)\",\"Pathan in Pakistan (SGDP)\",\"Greek in Greece (SGDP)\",\"French in France (SGDP)\",\"Armenian in Armenia (SGDP)\",\"Yemenite Jew in Yemen (SGDP)\",\"Turkish in Turkey (SGDP)\",\"French in France (SGDP)\",\"Basque in France (SGDP)\",\"Lezgin in Russia (SGDP)\",\"Greek in Greece (SGDP)\",\"Albanian in Albania (SGDP)\",\"Hungarian in Hungary (SGDP)\",\"Sardinian in Italy (SGDP)\",\"Jordanian in Jordan (SGDP)\",\"Iraqi Jew in Iraq (SGDP)\",\"Crete in Greece (SGDP)\",\"Icelandic in Iceland (SGDP)\",\"Tuscan in Italy(Tuscany) (SGDP)\",\"Crete in Greece (SGDP)\",\"Palestinian in Israel(Central) (SGDP)\",\"Polish in Poland (SGDP)\",\"Spanish in Spain (SGDP)\",\"Sardinian in Italy (SGDP)\",\"Kalash in Pakistan 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in Papua New Guinea (SGDP)\",\"Punjabi in Pakistan (SGDP)\",\"Australian in Australia (SGDP)\",\"Saami in Finland (SGDP)\",\"Sindhi in Pakistan (SGDP)\",\"Abkhasian in Abkhazia or Russia (SGDP)\",\"Kapu in India (SGDP)\",\"Saami in Finland (SGDP)\",\"Finnish in Finland (SGDP)\",\"Papuan in Papua New Guinea (SGDP)\",\"Papuan in Papua New Guinea (SGDP)\",\"Burusho in Pakistan (SGDP)\",\"North Ossetian in Russia (SGDP)\",\"Papuan in Papua New Guinea (SGDP)\",\"Bengali in Bangladesh (SGDP)\",\"Chechen in Russia (SGDP)\",\"Russian in Russia (SGDP)\",\"Estonian in Estonia (SGDP)\",\"Brahmin in India (SGDP)\",\"Papuan in Papua New Guinea (SGDP)\",\"Yadava in India (SGDP)\",\"Papuan in Papua New Guinea (SGDP)\",\"Irula in India (SGDP)\",\"Relli in India (SGDP)\",\"Papuan in Papua New Guinea (SGDP)\",\"Australian in Australia (SGDP)\",\"Burmese in Myanmar (SGDP)\",\"Chukchi in Russia (SGDP)\",\"Balochi in Pakistan (SGDP)\",\"Papuan in Papua New Guinea (SGDP)\",\"Brahmin in India 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(SGDP)\",\"Dai in China (SGDP)\",\"She in China (SGDP)\",\"Dusun in Brunei (SGDP)\",\"Oroqen in China (SGDP)\",\"Lahu in China (SGDP)\",\"She in China (SGDP)\",\"Naxi in China (SGDP)\",\"Igorot in Philippines (SGDP)\",\"Itelman in Russia (SGDP)\",\"NA\",\"Tu in China (SGDP)\",\"Eskimo Sireniki in Russia (SGDP)\",\"Altaian in Russia (SGDP)\",\"Kinh in Vietnam (SGDP)\",\"Hawaiian in USA (SGDP)\",\"Kyrgyz in Kyrgyzystan (SGDP)\",\"Mixtec in Mexico (SGDP)\",\"Hezhen in China (SGDP)\",\"Dusun in Brunei (SGDP)\",\"Han in China (SGDP)\",\"Xibo in China (SGDP)\",\"Yakut in Russia (SGDP)\",\"Dai in China (SGDP)\",\"Oroqen in China (SGDP)\",\"Dai in China (SGDP)\",\"Lahu in China (SGDP)\",\"Igorot in Philippines (SGDP)\",\"Russian in Russia (SGDP)\",\"Mongola in China (SGDP)\",\"Hezhen in China (SGDP)\",\"Surui in Brazil (SGDP)\",\"Han in China (SGDP)\",\"Ami in Taiwan (SGDP)\",\"Mixe in Mexico (SGDP)\",\"Mixtec in Mexico (SGDP)\",\"Naxi in China (SGDP)\",\"Tujia in China (SGDP)\",\"Naxi in 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(SGDP)\"},\"id\":\"3357\",\"type\":\"GroupFilter\"},{\"attributes\":{\"text\":\"PCA\"},\"id\":\"3015\",\"type\":\"Title\"}],\"root_ids\":[\"3014\"]},\"title\":\"Bokeh Application\",\"version\":\"1.4.0\"}};\n",
       "  var render_items = [{\"docid\":\"06133897-55db-47e7-9baa-d1cd5c335c6b\",\"roots\":{\"3014\":\"864cbb7d-5f1b-4faf-a521-dd0ec4381084\"}}];\n",
       "  root.Bokeh.embed.embed_items_notebook(docs_json, render_items);\n",
       "\n",
       "  }\n",
       "  if (root.Bokeh !== undefined) {\n",
       "    embed_document(root);\n",
       "  } else {\n",
       "    var attempts = 0;\n",
       "    var timer = setInterval(function(root) {\n",
       "      if (root.Bokeh !== undefined) {\n",
       "        clearInterval(timer);\n",
       "        embed_document(root);\n",
       "      } else {\n",
       "        attempts++;\n",
       "        if (attempts > 100) {\n",
       "          clearInterval(timer);\n",
       "          console.log(\"Bokeh: ERROR: Unable to run BokehJS code because BokehJS library is missing\");\n",
       "        }\n",
       "      }\n",
       "    }, 10, root)\n",
       "  }\n",
       "})(window);"
      ],
      "application/vnd.bokehjs_exec.v0+json": ""
     },
     "metadata": {
      "application/vnd.bokehjs_exec.v0+json": {
       "id": "3014"
      }
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "from bokeh.models import  CategoricalColorMapper\n",
    "from bokeh.palettes import Category10\n",
    "\n",
    "pallete=Category10[7]\n",
    "colors={\n",
    "    'Africa': \"#12eeff\",\n",
    "    'America': '#310079',\n",
    "    'Central Asia and Siberia': '#01daa0',\n",
    "    'East Asia':'#ff48de',\n",
    "    'Oceania':\"#34afff\",\n",
    "    \"South Asia\":\"#008c1e\",\n",
    "    \"West Eurasia\":\"#001f54\",\n",
    "    None: pallete[6]\n",
    "}\n",
    "\n",
    "\n",
    "colorTable={}\n",
    "for s in table.collect():\n",
    "    colorTable[s.population]=colors[s.super_population]\n",
    "\n",
    "factors=[]\n",
    "pallete=[]\n",
    "for k,v in colorTable.items():\n",
    "    factors.append(k)\n",
    "    pallete.append(v)\n",
    "    \n",
    "color_mapper = CategoricalColorMapper(factors=factors, palette=pallete)    \n",
    "\n",
    "p = hl.plot.scatter(mt.scores[0],\n",
    "                    mt.scores[1],\n",
    "                    label=mt.population.population,\n",
    "                    colors=color_mapper,\n",
    "                    title='PCA', xlabel='PC1', ylabel='PC2')\n",
    "show(p)"
   ]
  }
 ],
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