[Maxquant] Abnormal runtime for second peptide search

[li-chin]

Describe the bug

Maxquant analysis takes more than 128 hours at "second peptide search" step.
This has happened twice (repeated the same analysis from the start of analysis, but it is still the same)

I am comparing the steps according to the publication on the Maxquant's expected run time:

My first search, main search and MS/MS preparation took only 45min to a few hours as per below:

Desktop (please complete the following information):

• OS: Windows 10 Pro for Workstations
• Version: 22H2

Appreciate your feedback on this issue. Thank you.