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JN.1 plus S:T572I and S:E1150D (63 Seqs - 8 countries) #2428

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FedeGueli opened this issue Dec 27, 2023 · 4 comments
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JN.1 plus S:T572I and S:E1150D (63 Seqs - 8 countries) #2428

FedeGueli opened this issue Dec 27, 2023 · 4 comments

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@FedeGueli
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FedeGueli commented Dec 27, 2023

This is Branch 1 of sars-cov-2-variants/lineage-proposals#1097

S:T572I is highly homoplasic in JN.1 as we saw in XBB.1.22.1 descendants and as shown by Dadonaite and Bloom it is a mutation able to restore SCE2 binding loss.

Defining mutations:
JN.1 > C25566T > S:T572I (C23277T),S:E1150D (G25012T)
Query: A7842G, G25012T, C25566T,C23277T
Samples : 29

Genomes EPI_ISL_18516431, EPI_ISL_18577370, EPI_ISL_18592154, EPI_ISL_18618109, EPI_ISL_18618170, EPI_ISL_18640642, EPI_ISL_18640647, EPI_ISL_18647279, EPI_ISL_18653194, EPI_ISL_18653253, EPI_ISL_18660977, EPI_ISL_18662082, EPI_ISL_18662562, EPI_ISL_18663699, EPI_ISL_18673598, EPI_ISL_18676208, EPI_ISL_18676747, EPI_ISL_18677028, EPI_ISL_18681722, EPI_ISL_18684593, EPI_ISL_18688474, EPI_ISL_18690123, EPI_ISL_18690219, EPI_ISL_18690922, EPI_ISL_18691710, EPI_ISL_18691894, EPI_ISL_18692383, EPI_ISL_18692386, EPI_ISL_18692393
Countries: 6 (Uk, US, France, Ireland, Netherlands and Spain - via GBW)

Tree:
Schermata 2023-12-27 alle 17 08 37
https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_4170_c4be00.json?label=id:node_6806014

@HynnSpylor
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35 seqs now. The branch grows quite fast in US

@FedeGueli FedeGueli changed the title JN.1 plus S:T572I and S:E1150D (29 Seqs - 6 countries) JN.1 plus S:T572I and S:E1150D (36 Seqs - 6 countries) Dec 29, 2023
@FedeGueli
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+1 Singapore

@FedeGueli FedeGueli changed the title JN.1 plus S:T572I and S:E1150D (36 Seqs - 6 countries) JN.1 plus S:T572I and S:E1150D (63 Seqs - 8 countries) Jan 6, 2024
@FedeGueli
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63 seqs 8 countries ping @corneliusroemer

@FedeGueli
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Designated JN.1.7

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