The Sweden Cancerome Analysis Network--Breast (SCAN-B) initiative (ClinicalTrials.gov identifier NCT02306096) is a population-based, multicenter breast cancer study that started enrolling patients in 2010. The study is described in Saal et al, Genome Medicine (2015) and Rydén et al, British Journal of Surgery (2018).
This software was developed as part of a PhD research project in the laboratory of Lao H. Saal, Translational Oncogenomics Unit, Department of Oncology and Pathology, Lund University, Sweden.
- 20191117 Updated overall survival (OS), bringing median follow-up time to 74.5 months (previously 63.9 months).
- 20191004 Initial public release of MutationExplorer and this dataset.
If you would like access to mutational data beyond what is accessible through this application, please contact Lao H Saal. Gene/isoform expression data for the samples included here is publicly available from the NCBI Gene Expression Omnibus series GSE96058 and described in Brueffer and Vallon-Christersson et al, JCO Precision Oncology (2018).
If you use any data or plots from this website in your publications, or if you adopt this software for your own dataset, please cite the following publication:
Brueffer et al (2020). The mutational landscape of the SCAN-B real-world primary breast cancer transcriptome. EMBO Molecular Medicine, 12(10):e12118. DOI: 10.15252/emmm.202012118
The source code for this software is available under the 2-clause BSD license and can be found on GitHub: https://github.com/cbrueffer/MutationExplorer
- Christian Brueffer (christian.brueffer@med.lu.se)
- Lao H Saal (lao.saal@med.lu.se)