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DESCRIPTION
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DESCRIPTION
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Package: scMET
Type: Package
Title: Bayesian modelling of cell-to-cell DNA methylation heterogeneity
Version: 0.99.11
Authors@R:
c(person(given = "Andreas C.",
family = "Kapourani",
role = c("aut", "cre"),
email = "kapouranis.andreas@gmail.com",
comment = c(ORCID = "0000-0003-2303-1953")),
person(given = "John",
family = "Riddell",
role = c("ctb")))
Description: High-throughput single-cell measurements of DNA methylomes can
quantify methylation heterogeneity and uncover its role in gene regulation.
However, technical limitations and sparse coverage can preclude this task.
scMET is a hierarchical Bayesian model which overcomes sparsity,
sharing information across cells and genomic features to robustly
quantify genuine biological heterogeneity. scMET can identify highly
variable features that drive epigenetic heterogeneity, and perform
differential methylation and variability analyses. We illustrate how
scMET facilitates the characterization of epigenetically distinct cell
populations and how it enables the formulation of novel hypotheses on the
epigenetic regulation of gene expression.
License: GPL-3
Encoding: UTF-8
LazyData: true
Roxygen: list(markdown = TRUE)
RoxygenNote: 7.2.0
Biarch: true
BugReports: https://github.com/andreaskapou/scMET/issues
Depends:
R (>= 4.2.0)
Imports:
methods,
Rcpp (>= 1.0.0),
RcppParallel (>= 5.0.1),
rstan (>= 2.21.3),
rstantools (>= 2.1.0),
VGAM,
data.table,
MASS,
logitnorm,
ggplot2,
matrixStats,
assertthat,
viridis,
coda,
BiocStyle,
cowplot,
stats,
SummarizedExperiment,
SingleCellExperiment,
Matrix,
dplyr,
S4Vectors
Suggests:
testthat,
knitr,
rmarkdown
LinkingTo:
BH (>= 1.66.0),
Rcpp (>= 1.0.0),
RcppEigen (>= 0.3.3.3.0),
RcppParallel (>= 5.0.1),
rstan (>= 2.21.3),
StanHeaders (>= 2.21.0.7)
SystemRequirements: GNU make
biocViews: ImmunoOncology,
DNAMethylation,
DifferentialMethylation,
DifferentialExpression,
GeneExpression,
GeneRegulation,
Epigenetics,
Genetics,
Clustering,
FeatureExtraction,
Regression,
Bayesian,
Sequencing,
Coverage,
SingleCell
VignetteBuilder: knitr