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Gained TADs in condition 2 #19
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In Condition 2, a TAD gained is equivalent to the loss of the TAD in Condition 1. To identify such TADs, swap Condition 2 as Condition 1 in the input for DiffDomain. See the example code below. |
Hi Dechao, Thank you so much for your response! So for the final list of changed TADs in condition 2, should I integrate gain to other 6 types together? I could not see the gained TAD class in Nature communication paper. Pinpin |
Hey Pinpin There is no need to integrate gained TADs into the reorganized TADs in DiffDomain. The current formulation of DiffDomain focuses on testing whether TADs from condition 1 are reorganized in condition 2, and then classifies the resulting reorganized TADs into 6 subtypes. In cases where there are gained TADs in condition 2, we can treat condition 2 as the new condition 1 in the input of DiffDomain. This approach allows us to classify the gained TADs in condition 2 as lost TADs in condition 1, without needing to integrate them into the reorganized TADs. Dechao |
Hi Dechao, Appeciate your explanation! Thank you again for this wonderful diffdomain! Pinpin |
Hi Dechao, Thank you again! Another question, how to distinguish the strength change up and strength change down TADs with diffdomain? Pinpin Sui |
Hi,
Thanks for this wonderful tool to see the TAD changes among 2 condition!
How to identity the gained loops in condition 2?
Thank you,
Pinpin Sui
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