Review LOINC 26506-6 Segmented neutrophils/100 leukocytes in Cerebral spinal fluid

[kingmanzhang]

@callahantiff

[callahantiff]

@nicolevasilevsky this one was a tricky one. I think we may want a series of new terms for annotating this.

Would you suggest something like:

• Abnormality of neutrophil morphology in CSF
• Hyposegmentation of neutrophil nuclei in CSF
• Hypersegmentation of neutrophil nuclei in CSF

Where the parent term for Abnormality of neutrophil morphology in CSF would be Abnormality of the cerebrospinal fluid (HP:0002921)? Right now there exist terms for Abnormality of neutrophil morphology, Hyposegmentation of neutrophil nuclei, and Hypersegmentation of neutrophil nuclei, they are just not currently specified for CSF.

[nicolevasilevsky]

@pnrobinson do we want to create terms that specify that the hypo/hyper segmented neutrophils are present in the CSF or would using the HP_0004821 'Hypersegmentation of neutrophil nuclei' and HP_0011447 'Hyposegmentation of neutrophil nuclei' be sufficient?

[pnrobinson]

The latter classes are meant to mean in the blood, and that would be 99% of actual use cases. We should make exact synonyms for the latter terms along the lines of " ... in peripheral blood".
I think the only way is to have separate CSF terms for the above.

[nicolevasilevsky]

@callahantiff I added these terms:
HP_0410310 'Abnormality of neutrophil morphology in CSF'
HP_0410312 'Hypersegmentation of neutrophil nuclei in CSF'
HP_0410311 'Hyposegmentation of neutrophil nuclei in CSF'

(FYI, I added them as children of Abnormality of the cerebrospinal fluid, and added the logical definition to HP_0410310 below, so now they are asserted as children of Abn of CSF, but are inferred to be children of Abnormality of neutrophil morphology.)

@drseb and @matentzn - I used 'inheres in part of' because that is what was used for HP_0011992 'Abnormality of neutrophil morphology', is this correct?

'has part' some
(morphology
and ('inheres in part of' some (neutrophil and ('part of' some 'cerebrospinal fluid')))
and ('has modifier' some abnormal))

[callahantiff]

Thank you, that makes sense to me!